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Gypa Gene Detail
Summary
  • Symbol
    Gypa
  • Name
    glycophorin A
  • Synonyms
    CD235a, GPA
  • Feature Type
    protein coding gene
  • IDs
    MGI:95880
    NCBI Gene: 14934
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:81220674-81237414 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 38.27 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    599 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95880
 protein coding gene Chr8:81220410-81237414 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033817
 protein coding gene Chr8:81209440-81226783 (+)
A/J MGP_AJ_G0033799
 protein coding gene Chr8:77973854-77990214 (+)
AKR/J MGP_AKRJ_G0033726
 protein coding gene Chr8:80310003-80328158 (+)
BALB/cJ MGP_BALBcJ_G0033793
 protein coding gene Chr8:78091771-78109879 (+)
C3H/HeJ MGP_C3HHeJ_G0033502
 protein coding gene Chr8:80946859-80964482 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034313
 protein coding gene Chr8:84337847-84357034 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031254
 protein coding gene Chr8:71990421-72006954 (+)
CAST/EiJ MGP_CASTEiJ_G0032833
 protein coding gene Chr8:80281742-80303273 (+)
CBA/J MGP_CBAJ_G0033481
 protein coding gene Chr8:87313857-87339420 (+)
DBA/2J MGP_DBA2J_G0033634
 protein coding gene Chr8:77676108-77692282 (+)
FVB/NJ MGP_FVBNJ_G0033579
 protein coding gene Chr8:76618560-76634764 (+)
LP/J MGP_LPJ_G0033724
 protein coding gene Chr8:81304363-81321488 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033622
 protein coding gene Chr8:89819640-89837787 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034330
 protein coding gene Chr8:80334740-80351620 (+)
PWK/PhJ MGP_PWKPhJ_G0032536
 protein coding gene Chr8:76927210-76944678 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032374
 protein coding gene Chr8:79126413-79144717 (+)
WSB/EiJ MGP_WSBEiJ_G0032946
 protein coding gene Chr8:80674389-80694858 (+)



Homology
more
  • Human Ortholog
    GYPA, glycophorin A (MNS blood group)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GYPA, glycophorin A (MNS blood group)
  • Synonyms
    CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2
  • Links
    NCBI Gene ID: 2993
    neXtProt AC: NX_P02724
    UniProt: P02724

  • Chr Location
    4q31.21; chr4:144109303-144140751 (-)  GRCh38
  • Human Ortholog
    GYPB, glycophorin B (MNS blood group)
  • Synonyms
    CD235b, GPB, GYP, GYPA, MNS, PAS-3, SS
  • Links
    NCBI Gene ID: 2994
    neXtProt AC: NX_P06028
    UniProt: P06028

  • Chr Location
    4q31.21; chr4:143995188-144019380 (-)  GRCh38
  • Human Ortholog
    GYPE, glycophorin E (MNS blood group)
  • Synonyms
    GPE, GYPA, MiIX, MNS
  • Links
    NCBI Gene ID: 2996
    neXtProt AC: NX_P15421
    UniProt: P15421

  • Chr Location
    4q31.21; chr4:143870864-143905563 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GYPA,GYPB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable and fertile; however, mutant erythrocytes had a reduced percentage of O-linked glycoproteins in the membranes, and were sensitive to hypoosmotic stress.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    3
  • cDNA Data
    15
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14934 NCBI Gene Model | MGI Sequence Detail 16741 C57BL/6J ±  kb
transcript NM_010369 RefSeq | MGI Sequence Detail 1827 ZRU/MplStud  
polypeptide P14220 UniProt | EBI | MGI Sequence Detail 168 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR001195 Glycophorin
    IPR049535 Glycophorin A/B
    IPR018938 Glycophorin, conserved site
  • GlyGen
    P14220 1 site, 9 N-linked glycans (1 site), 6 O-linked glycans (1 site)
Molecular
Reagents
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  • All nucleic 22
    Genomic 4
    cDNA 15
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10344, MGI:2142640
References
more
  • Summaries
    All 79
    Developmental Gene Expression 10
    Gene Ontology 5
    Phenotypes 39
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
  • Latest
    J:348117 Okuma H, et al., N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on alpha-dystroglycan and prevents muscular dystrophy. Elife. 2023 Feb 1;12
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory