H2 Complex/Cluster/Region Detail

Summary

• Symbol
  H2
• Name
  histocompatibility-2, MHC
• Synonyms
  H-2, MHC-II

• Feature Type
  complex/cluster/region
• IDs
  MGI:95894
  NCBI Gene: 111364

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, cytoband B-C
• Mapping Data
  216 experiments

Strain
Comparison

• RFLP
  12

Human Diseases

• Mutations/Alleles
  5 with disease annotations

• References
  7 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  23 phenotypes from 9 alleles in 11 genetic backgrounds
  89 phenotypes from multigenic genotypes
  2 images
  534 phenotype references
  

• All Mutations and Alleles
  47
• Endonuclease-mediated
  4
• Spontaneous
  14
• Targeted
  1
• Transgenic
  11
• Find Mice (IMSR)
  282 strains or lines available

The H2 complex contains 3 major classes of highly polymorphic gene sets: class I (H2-K, H2-D, H2-Q, H2-T18 genes), class II (H2-I genes), and class III (H2-S genes). These genes are involved in many processes, including graft rejection, immune response, antigen presentation and complement component.

Expression

• cDNA Data
  5
• Literature Summary
  4

Sequences &
Gene Models

• NCBI Gene
  111364

Molecular
Reagents

• All nucleic 10

  cDNA 8

  Other 2

Other
Accession IDs

MGD-MRK-10366, MGD-MRK-10489

References

• Summaries
  All 855

  Developmental Gene Expression 4

  Diseases 7

  Phenotypes 534
• Earliest
  J:301 Snell GD, Preliminary data on crossing-over between H-2, and Fu, Ki and T in the mouse. Heredity. 1952;6(2):247-54
• Latest
  J:355474 Mitchell JS, et al., CD4(+) T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes. Immunity. 2024 Oct 8;57(10):2399-2415.e8