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H2-Ea Pseudogene Detail
Summary
  • Symbol
    H2-Ea
  • Name
    histocompatibility 2, class II antigen E alpha
  • Synonyms
    H-2Ea, H2-Ea-ps, Ia-3, Ia3, I-Ealpha
Location &
Maps
more
  • Sequence Map
    Chr17:34560926-34563618 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    31 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    42
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95900
 polymorphic pseudogene Chr17:34560926-34563619 (-)
129S1/SvImJ MGP_129S1SvImJ_G0040151
 pseudogene Chr17:34352697-34354415 (-)
A/J MGP_AJ_G0040144
 pseudogene Chr17:33184744-33186450 (-)
AKR/J MGP_AKRJ_G0040067
 pseudogene Chr17:33575579-33577281 (-)
BALB/cJ MGP_BALBcJ_G0040130
 pseudogene Chr17:33344981-33346699 (-)
C3H/HeJ MGP_C3HHeJ_G0039776
 pseudogene Chr17:33931964-33934530 (-)
C57BL/6NJ MGP_C57BL6NJ_G0040720
 pseudogene Chr17:35637011-35638719 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0037187
 pseudogene Chr17:31153519-31155221 (-)
CAST/EiJ MGP_CASTEiJ_G0038867
 pseudogene Chr17:34018073-34019770 (-)
CBA/J MGP_CBAJ_G0039742
 pseudogene Chr17:37106241-37107947 (-)
DBA/2J MGP_DBA2J_G0039940
 pseudogene Chr17:32529408-32531106 (-)
FVB/NJ MGP_FVBNJ_G0039901
 pseudogene Chr17:32386963-32388662 (-)
LP/J MGP_LPJ_G0039985
 pseudogene Chr17:34611942-34613711 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0039889
 pseudogene Chr17:36076074-36077786 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0040818
 pseudogene Chr17:33905091-33906793 (-)
PWK/PhJ MGP_PWKPhJ_G0038558
 pseudogene Chr17:31468330-31470083 (-)
SPRET/EiJ MGP_SPRETEiJ_G0038262
 pseudogene Chr17:31867337-31869051 (-)
WSB/EiJ MGP_WSBEiJ_G0039091
 pseudogene Chr17:33946739-33948434 (-)



Homology
more
  • Human Ortholog
    HLA-DRA, major histocompatibility complex, class II, DR alpha
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-DRA, major histocompatibility complex, class II, DR alpha
  • Synonyms
    HLA-DRA1
  • Links
    NCBI Gene ID: 3122
    neXtProt AC: NX_P01903
    UniProt: P01903

  • Chr Location
    6p21.32; chr6:32439878-32445046 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human HLA-DRA associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
 View 1 model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from multigenic genotypes
    230 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
Sequences &
Gene Models
less
  • All Sequences
    46
  • RefSeq
    3
  • UniProt
    6
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036322 Ensembl Gene Model | MGI Sequence Detail 2693 C57BL/6J ±  kb
transcript ENSMUST00000134042 Ensembl | MGI Sequence Detail 1042 Not Applicable  
polypeptide ENSMUSP00000158275 Ensembl | MGI Sequence Detail 228 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    Genomic 52
    cDNA 8
    Primer pair 2
    Other 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-10383, MGD-MRK-10496, MGD-MRK-11046, MGD-MRK-11051, MGI:2146825, MGI:6360898
References
more
  • Summaries
    All 303
    Diseases 1
    Gene Ontology 7
    Phenotypes 230
  • Earliest
    J:5527 Shreffler DC, et al., The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization. Adv Immunol. 1975;20:125-95
  • Latest
    J:350703 Sharma P, et al., The lipid globotriaosylceramide promotes germinal center B cell responses and antiviral immunity. Science. 2024 Feb 16;383(6684):eadg0564
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory