H2-I Complex/Cluster/Region Detail

Summary

• Symbol
  H2-I
• Name
  H2 I region, includes H2-Aa, Ab, Bl, Ea, Eb, Eb2, Ob, Pb
• Synonyms
  H-2I

• Feature Type
  complex/cluster/region
• IDs
  MGI:95903
  NCBI Gene: 111861

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, Syntenic
• Mapping Data
  4 experiments

Human Diseases

• Diseases
  1 with H2-I mouse models

Human Disease

Mouse Models

type 1 diabetes mellitus

IDs

type 1 diabetes mellitus      

DOID:9744
ICD10CM:E10
KEGG:04940
MESH:D003922
NCI:C2986
OMIM:222100
UMLS_CUI:C0011854

View 1 model

Mouse Models

Human Disease Modeled: type 1 diabetes mellitus

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(H2-Ead)12Lt/0	NOD/ShiLt-Tg(H2-Ea^d)12Lt	J:36435	View

NOT Models
No similarity to the expected human disease phenotype was found.

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(H2-Ead)5Lt/0	NOD/ShiLt-Tg(H2-Ea^d)5Lt	J:36435	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  2 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotypes from 3 alleles in 3 genetic backgrounds
  16 phenotypes from multigenic genotypes
  28 phenotype references
  

• All Mutations and Alleles
  7
• Transgenic
  7
• Find Mice (IMSR)
  12 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  111861

Other
Accession IDs

MGD-MRK-10387, MGD-MRK-10499

References

• Summaries
  All 48

  Diseases 1

  Phenotypes 28
• Earliest
  J:5712 Frelinger JA, et al., Effects of anti-Ia sera on mitogenic responses. III. Mapping the genes controlling the expression of Ia determinants on concanavalin A-reactive cells to the I-J subregion of the H-2 gene complex. J Exp Med. 1976 Oct 1;144(4):1141-6
• Latest
  J:281514 Cebula A, et al., Dormant pathogenic CD4(+) T cells are prevalent in the peripheral repertoire of healthy mice. Nat Commun. 2019 Oct 25;10(1):4882