H2-Oa MGI Mouse Gene Detail - MGI:95924 - histocompatibility 2, O region alpha locus

Symbol

H2-Oa
Name

histocompatibility 2, O region alpha locus
Synonyms

H-2Oa

Feature Type

protein coding gene
IDs

MGI:95924
NCBI Gene: 15001
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:34311314-34314208 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 17.98 cM
Mapping Data

4 experiments

Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95924	protein coding gene	Chr17:34311314-34314286 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023556	protein coding gene	Chr17:34066260-34069154 (+)
A/J	MGP_AJ_G0023520	protein coding gene	Chr17:32884351-32887232 (+)
AKR/J	MGP_AKRJ_G0023483	protein coding gene	Chr17:33300892-33303773 (+)
BALB/cJ	MGP_BALBcJ_G0023522	protein coding gene	Chr17:33057660-33060553 (+)
C3H/HeJ	MGP_C3HHeJ_G0023283	protein coding gene	Chr17:33654965-33657846 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023963	protein coding gene	Chr17:35368377-35371271 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021441	protein coding gene	Chr17:30424261-30427218 (+)
CAST/EiJ	MGP_CASTEiJ_G0022782	protein coding gene	Chr17:33754552-33757443 (+)
CBA/J	MGP_CBAJ_G0023260	protein coding gene	Chr17:36768455-36771336 (+)
DBA/2J	MGP_DBA2J_G0023391	protein coding gene	Chr17:32268340-32271220 (+)
FVB/NJ	MGP_FVBNJ_G0023355	protein coding gene	Chr17:32136264-32139400 (+)
LP/J	MGP_LPJ_G0023466	protein coding gene	Chr17:34345416-34348310 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023378	protein coding gene	Chr17:35809627-35812520 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024005	protein coding gene	Chr17:33649323-33652216 (+)
PWK/PhJ	MGP_PWKPhJ_G0022532	protein coding gene	Chr17:31195725-31198616 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022347	protein coding gene	Chr17:31595244-31599240 (+)
WSB/EiJ	MGP_WSBEiJ_G0022843	protein coding gene	Chr17:33658120-33660998 (+)

Human Ortholog

HLA-DOA, major histocompatibility complex, class II, DO alpha

Vertebrate Orthologs

8

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HLA-DOA, major histocompatibility complex, class II, DO alpha
Synonyms

HLA-DNA, HLADZ, HLA-DZA
Links

HGNC:4936

NCBI Gene ID: 3111

neXtProt AC: NX_P06340

UniProt: P06340
Chr Location

6p21.32; chr6:33004182-33009591 (-) GRCh38

MGI Vertebrate Homology

H2-Oa stringent orthology
1 human;1 mouse;1 rat;6 zebrafish
HCOP

vertebrate homology predictions: HLA-DOA
Gene Tree

H2-Oa

Diseases

1 with human HLA-DOA associations

				Human Disease	Mouse Models
				occupational asthma IDs occupational asthma DOID:0080820

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 3 alleles in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Targeted

4
Transgenic

1
Incidental Mutations

APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene results in abnormal antigen presentation via MHC class II. Mice homozygous for a knock-out allele show enhanced selection of CD4+ single positive thymocytes. Mice homozygous for a different knock-out allele show increased serum IgG1 levels.

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All GO Annotations

15
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

827
Tissues

15
cDNA Data

21
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

4
UniProt

3
CCDS

CCDS37577.1

Ensembl

ENSMUSG00000024334 (Evidence)
NCBI Gene

15001

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024334	Ensembl Gene Model \| MGI Sequence Detail	2895	C57BL/6J	± kb
transcript	ENSMUST00000025192	Ensembl \| MGI Sequence Detail	1088	Not Applicable
polypeptide	ENSMUSP00000025192	Ensembl \| MGI Sequence Detail	250	Not Applicable

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UniProt

3 Sequences
InterPro Domains

IPR003597 Immunoglobulin C1-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003006 Immunoglobulin/major histocompatibility complex, conserved site

IPR050160 Major Histocompatibility Complex/Immunoglobulin

IPR011162 MHC classes I/II-like antigen recognition protein

IPR014745 MHC class II, alpha/beta chain, N-terminal

IPR001003 MHC class II, alpha chain, N-terminal

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All nucleic 30

Genomic 8

cDNA 21

Primer pair 1

Microarray probesets 3

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MGD-MRK-10408, MGD-MRK-10520

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 17
Earliest

J:1569 Karlsson L, et al., The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complex. J Exp Med. 1992 Aug 1;176(2):477-83
Latest

J:342263 Song N, et al., Proper development of long-lived memory CD4 T cells requires HLA-DO function. Front Immunol. 2023;14:1277609

TSS for H2-Oa:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143894	Chr17:34311329-34311340 (+)	21 bp
Tssr143895	Chr17:34311350-34311395 (+)	59 bp
Tssr143896	Chr17:34311823-34311832 (+)	514 bp
Tssr143897	Chr17:34311847-34311865 (+)	542 bp
Tssr143898	Chr17:34311879-34311890 (+)	571 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24