H2-Ob MGI Mouse Gene Detail - MGI:95925 - histocompatibility 2, O region beta locus

Symbol

H2-Ob
Name

histocompatibility 2, O region beta locus
Synonyms

A-beta-2, A-beta2, H2-Ab, H2-Ab2, H-2I, H2-IAb2, H-2Ob, Ob, vic1

Feature Type

protein coding gene
IDs

MGI:95925
NCBI Gene: 15002
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr17:34457879-34464882 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 17.98 cM
Mapping Data

10 experiments

SNPs within 2kb

6 from dbSNP Build 142
Strain Annotations

18
RFLP

33

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95925	protein coding gene	Chr17:34457877-34473388 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023566	protein coding gene	Chr17:34241211-34249719 (+)
A/J	MGP_AJ_G0023528	protein coding gene	Chr17:33068673-33076883 (+)
AKR/J	MGP_AKRJ_G0023493	protein coding gene	Chr17:33454798-33461870 (+)
BALB/cJ	MGP_BALBcJ_G0023532	protein coding gene	Chr17:33234126-33242383 (+)
C3H/HeJ	MGP_C3HHeJ_G0023292	protein coding gene	Chr17:33811576-33820918 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023972	protein coding gene	Chr17:35528840-35535828 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021451	protein coding gene	Chr17:30558433-30565705 (+)
CAST/EiJ	MGP_CASTEiJ_G0022792	protein coding gene	Chr17:33907748-33915446 (+)
CBA/J	MGP_CBAJ_G0023270	protein coding gene	Chr17:36981992-36991638 (+)
DBA/2J	MGP_DBA2J_G0023399	protein coding gene	Chr17:32422598-32429837 (+)
FVB/NJ	MGP_FVBNJ_G0023365	protein coding gene	Chr17:32283408-32290209 (+)
LP/J	MGP_LPJ_G0023476	protein coding gene	Chr17:34499030-34507553 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023388	protein coding gene	Chr17:35955791-35963441 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024015	protein coding gene	Chr17:33794028-33802206 (+)
PWK/PhJ	MGP_PWKPhJ_G0022542	protein coding gene	Chr17:31357254-31364713 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022357	protein coding gene	Chr17:31752827-31759766 (+)
WSB/EiJ	MGP_WSBEiJ_G0022853	protein coding gene	Chr17:33832779-33839801 (+)

Human Ortholog

HLA-DOB, major histocompatibility complex, class II, DO beta

Vertebrate Orthologs

9

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HLA-DOB, major histocompatibility complex, class II, DO beta
Synonyms

DOB, HLA_DOB
Links

HGNC:4937

NCBI Gene ID: 3112

neXtProt AC: NX_P13765

UniProt: P13765
Chr Location

6p21.32; chr6:32812763-32820466 (-) GRCh38

MGI Vertebrate Homology

H2-Ob stringent orthology
1 human;1 mouse;1 rat;7 zebrafish
HCOP

vertebrate homology predictions: HLA-DOB
Gene Tree

H2-Ob

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Phenotype Summary

5 phenotypes from 2 alleles in 5 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

4
Spontaneous

1
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available

Homozygous loss-of-function mutations in this gene result in defective assembly of class II molecules, decreased susceptibility to viral infection, and decreased incidence of MMTV-induced mammary tumors.

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All GO Annotations

14
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

9
cDNA Data

49
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

63
RefSeq

4
UniProt

10
CCDS

CCDS37582.1

Ensembl

ENSMUSG00000041538 (Evidence)
NCBI Gene

15002

			Length	Strain/Species	Flank
genomic	15002	NCBI Gene Model \| MGI Sequence Detail	7004	C57BL/6J	± kb
transcript	NM_010389	RefSeq \| MGI Sequence Detail	2670	ZRU/MplStud
polypeptide	NP_034519	RefSeq \| MGI Sequence Detail	271	ZRU/MplStud

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UniProt

10 Sequences
InterPro Domains

IPR003597 Immunoglobulin C1-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003006 Immunoglobulin/major histocompatibility complex, conserved site

IPR050160 Major Histocompatibility Complex/Immunoglobulin

IPR011162 MHC classes I/II-like antigen recognition protein

IPR014745 MHC class II, alpha/beta chain, N-terminal

IPR000353 MHC class II, beta chain, N-terminal

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All nucleic 76

Genomic 25

cDNA 49

Primer pair 2

Microarray probesets 3

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MGD-MRK-10378, MGD-MRK-10409, MGD-MRK-10491, MGD-MRK-10521, MGD-MRK-23933, MGI:3573871, MGI:894613

Summaries

All 56

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 12
Earliest

J:6885 Steinmetz M, et al., A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature. 1982 Nov 4;300(5887):35-42
Latest

J:342263 Song N, et al., Proper development of long-lived memory CD4 T cells requires HLA-DO function. Front Immunol. 2023;14:1277609

TSS for H2-Ob:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143949	Chr17:34457870-34457885 (+)	-1 bp
Tssr143950	Chr17:34457888-34457938 (+)	34 bp
Tssr143951	Chr17:34458845-34458855 (+)	971 bp
Tssr143952	Chr17:34458989-34459031 (+)	1,131 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24