H2-Q5 Pseudogene Detail

Summary

• Symbol
  H2-Q5
• Name
  histocompatibility 2, Q region locus 5
• Synonyms
  H-2Q5, Qa-5, Qa5, Qat-5

• Feature Type
  polymorphic pseudogene
  BioType Conflict
  
• IDs
  MGI:95934
  NCBI Gene: 15016
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr17:35613075-35614606 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 17, 18.65 cM
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  88 from dbSNP Build 142
• Strain Annotations
  6
• RFLP
  4

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95934	polymorphic pseudogene	Chr17:35613075-35616776 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0009939	polymorphic pseudogene	Chr17:35555712-35634629 (+)
A/J	no annotation
AKR/J	no annotation
BALB/cJ	MGP_BALBcJ_G0009908	polymorphic pseudogene	Chr17:35439665-35441299 (-)
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0009858	polymorphic pseudogene	Chr17:33406165-33602664 (+)
LP/J	MGP_LPJ_G0009936	polymorphic pseudogene	Chr17:35745373-35858521 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0009760	polymorphic pseudogene	Chr17:35119400-35120966 (+)

Homology

• Gene Tree
  H2-Q5
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Targeted
  1
• Genomic Mutations
  1 involving H2-Q5
• Find Mice (IMSR)
  9 strains or lines available

This locus controls a peripheral T-cell antigen identified by monoclonal AKR anti-B6 antibody. The a allele (antigen presence) is seen in C57BL/6, C57BL/10, BALB/c, 129, C58 and C57L; the b allele (antigen absence) in AKR, A/J, SJL, DBA/2, CBA/J, CBA/H, C3H/An, C57BR/cd, SEC/1, P, BDP, BUB and SWR.

Expression

• Assay Results
  757
• Tissues
  27
• cDNA Data
  5
• Literature Summary
  2

Images

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  26
• RefSeq
  1
• UniProt
  3

• Ensembl
  ENSMUSG00000055413 (Evidence)
• NCBI Gene
  15016

Representative Sequences			Length	Strain/Species
genomic	15016	NCBI Gene Model | MGI Sequence Detail	1532	C57BL/6J
transcript	NR_051981	RefSeq | MGI Sequence Detail	1181	ZRU/MplStud
polypeptide	F2WVG7	UniProt | EBI | MGI Sequence Detail	249	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• InterPro Domains
  IPR050208 Antigen-presenting and immune regulatory MHC class I-related
  IPR003597 Immunoglobulin C1-set
  IPR007110 Immunoglobulin-like domain
  IPR013783 Immunoglobulin-like fold
  IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
  IPR011162 MHC classes I/II-like antigen recognition protein
  IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
  IPR011161 MHC class I-like antigen recognition-like
  IPR037055 MHC class I-like antigen recognition-like superfamily

Molecular
Reagents

• All nucleic 37

  Genomic 25

  cDNA 6

  Primer pair 1

  Other 5

Other
Accession IDs

MGD-MRK-10417, MGD-MRK-10530, MGD-MRK-13713, MGD-MRK-13724, MGD-MRK-13730

References

• Summaries
  All 31

  Developmental Gene Expression 2

  Phenotypes 1
• Earliest
  J:6148 Hammerling GJ, et al., Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla region and identified by monoclonal antibodies. J Exp Med. 1979 Jul 1;150(1):108-16
• Latest
  J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25

TSS for H2-Q5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144366	Chr17:35613073-35613075 (+)	-1 bp