Hal Gene Detail

Summary

• Symbol
  Hal
• Name
  histidine ammonia lyase
• Synonyms
  histidase, Hsd

• Feature Type
  protein coding gene
• IDs
  MGI:96010
  NCBI Gene: 15109
• Alliance
  gene page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  Chr10:93324630-93352623 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 10, 48.49 cM, cytoband C2-D1
• Mapping Data
  25 experiments

Strain
Comparison

• SNPs within 2kb
  1127 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  8

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96010	protein coding gene	Chr10:93324630-93355166 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017651	protein coding gene	Chr10:94906630-94940562 (+)
A/J	MGP_AJ_G0017630	protein coding gene	Chr10:91604132-91634414 (+)
AKR/J	MGP_AKRJ_G0017588	protein coding gene	Chr10:94225582-94255946 (+)
BALB/cJ	MGP_BALBcJ_G0017593	protein coding gene	Chr10:91871019-91903842 (+)
C3H/HeJ	MGP_C3HHeJ_G0017416	protein coding gene	Chr10:94231029-94262577 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018050	protein coding gene	Chr10:98014630-98060280 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015732	protein coding gene	Chr10:87202640-87231957 (+)
CAST/EiJ	MGP_CASTEiJ_G0016981	protein coding gene	Chr10:94190615-94229609 (+)
CBA/J	MGP_CBAJ_G0017385	protein coding gene	Chr10:102101347-102137355 (+)
DBA/2J	MGP_DBA2J_G0017491	protein coding gene	Chr10:90701036-90732230 (+)
FVB/NJ	MGP_FVBNJ_G0017483	protein coding gene	Chr10:89910322-89941908 (+)
LP/J	MGP_LPJ_G0017565	protein coding gene	Chr10:95531797-95563778 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017514	protein coding gene	Chr10:103408330-103443483 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018087	protein coding gene	Chr10:94111591-94145910 (+)
PWK/PhJ	MGP_PWKPhJ_G0016762	protein coding gene	Chr10:90779881-90811426 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016550	protein coding gene	Chr10:92910753-92945423 (+)
WSB/EiJ	MGP_WSBEiJ_G0017040	protein coding gene	Chr10:94087216-94121436 (+)

Homology

• Human Ortholog
  HAL, histidine ammonia-lyase

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  HAL, histidine ammonia-lyase
  
• Synonyms
  HIS, HSTD
• Links
  HGNC:4806

  NCBI Gene ID: 3034

  neXtProt AC: NX_P42357

  UniProt: P42357

  
  
• Chr Location
  12q23.1; chr12:95972662-95996365 (-)  GRCh38

---

• MGI Vertebrate Homology
  Hal stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: HAL
• Gene Tree
  Hal
  

Human Diseases

• Diseases
  1 with human HAL associations

				Human Disease	Mouse Models
				histidinemia IDs histidinemia       DOID:0060168 MESH:C538320 OMIM:235800

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  21 phenotype references
  

• All Mutations and Alleles
  7
• Chemically induced (other)
  1
• Endonuclease-mediated
  2
• Gene trapped
  2
• Spontaneous
  1
• Transposon induced
  1
• Genomic Mutations
  2 involving Hal
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  40 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mutations in this gene cause elevated histidine levels.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  9
• GO References
  6

Expression

• Assay Results
  800
• Tissues
  94
• cDNA Data
  55
• Literature Summary
  2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase hal, hal.2

Sequences &
Gene Models

• All Sequences
  40
• RefSeq
  2
• UniProt
  5
• CCDS
  CCDS36036.1

• Ensembl
  ENSMUSG00000020017 (Evidence)
• NCBI Gene
  15109

Representative Sequences			Length	Strain/Species
genomic	15109	NCBI Gene Model | MGI Sequence Detail	27994	C57BL/6J
transcript	NM_010401	RefSeq | MGI Sequence Detail	2776	ZRU/MplStud
polypeptide	P35492	UniProt | EBI | MGI Sequence Detail	657	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000008437 histidine ammonia-lyase
  (term hierarchy)
• EC
  4.3.1.3
• InterPro Domains
  IPR001106 Aromatic amino acid lyase
  IPR024083 Fumarase/histidase, N-terminal
  IPR005921 Histidine ammonia-lyase
  IPR008948 L-Aspartase-like
  IPR021922 Par3/HAL, N-terminal
  IPR022313 Phenylalanine/histidine ammonia-lyases, active site

Molecular
Reagents

• All nucleic 57

  cDNA 57

  
  

  Microarray probesets 3

Other
Accession IDs

MGD-MRK-10611, MGD-MRK-10720, MGD-MRK-10944

References

• Summaries
  All 61

  Developmental Gene Expression 2

  Gene Ontology 6

  Phenotypes 21
• Earliest
  J:5382 Kacser H, et al., Histidinaemic mutant in the mouse. Nature. 1973 Jul 13;244(5411):77-9
• Latest
  J:236636 Planas-Paz L, et al., The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nat Cell Biol. 2016 May;18(5):467-79

TSS for Hal:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95263	Chr10:93324628-93324636 (+)	2 bp
Tssr95264	Chr10:93324921-93324938 (+)	300 bp
Tssr95265	Chr10:93337518-93337545 (+)	12,902 bp
Tssr95266	Chr10:93340195-93340204 (+)	15,570 bp