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Hao2 Gene Detail
Summary
  • Symbol
    Hao2
  • Name
    hydroxyacid oxidase 2
  • Synonyms
    Hao3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96012
    NCBI Gene: 56185
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:98781837-98800555 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 42.90 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    528 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96012
 protein coding gene Chr3:98781835-98802692 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027661
 protein coding gene Chr3:99916960-99947874 (-)
A/J MGP_AJ_G0027620
 protein coding gene Chr3:96750637-96771376 (-)
AKR/J MGP_AKRJ_G0027586
 protein coding gene Chr3:99074059-99091945 (-)
BALB/cJ MGP_BALBcJ_G0027633
 protein coding gene Chr3:96548756-96566667 (-)
C3H/HeJ MGP_C3HHeJ_G0027362
 protein coding gene Chr3:99421936-99440514 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028076
 protein coding gene Chr3:103635438-103654425 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025417
 protein coding gene Chr3:93062776-93080186 (-)
CAST/EiJ MGP_CASTEiJ_G0026818
 protein coding gene Chr3:98561380-98581525 (-)
CBA/J MGP_CBAJ_G0027337
 protein coding gene Chr3:107315317-107334124 (-)
DBA/2J MGP_DBA2J_G0027480
 protein coding gene Chr3:96019045-96037807 (-)
FVB/NJ MGP_FVBNJ_G0027448
 protein coding gene Chr3:93977033-93997193 (-)
LP/J MGP_LPJ_G0027587
 protein coding gene Chr3:101292650-101311945 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027478
 protein coding gene Chr3:113397523-113417839 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028131
 protein coding gene Chr3:98629888-98648944 (-)
PWK/PhJ MGP_PWKPhJ_G0026545
 protein coding gene Chr3:95809019-95827006 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026367
 protein coding gene Chr3:96761172-96779453 (-)
WSB/EiJ MGP_WSBEiJ_G0026898
 protein coding gene Chr3:99191995-99212842 (-)



Homology
more
  • Human Ortholog
    HAO2, hydroxyacid oxidase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HAO2, hydroxyacid oxidase 2
  • Synonyms
    GIG16, HAOX2
  • Links
    NCBI Gene ID: 51179
    neXtProt AC: NX_Q9NYQ3
    UniProt: Q9NYQ3

  • Chr Location
    1p12; chr1:119368779-119394130 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
Electrophoretic variants are known for this locus in kidney. The a allele determines a slow anodally migrating band in all inbred strains tested; the b allele determines a fast band in M. m. castaneus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    98
  • cDNA Data
    53
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027870 Ensembl Gene Model | MGI Sequence Detail 18719 C57BL/6J ±  kb
transcript ENSMUST00000029464 Ensembl | MGI Sequence Detail 2049 Not Applicable  
polypeptide ENSMUSP00000029464 Ensembl | MGI Sequence Detail 353 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    cDNA 53

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10617, MGD-MRK-10619, MGI:1860477, MGI:2139681
References
more
  • Summaries
    All 59
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:5932 Holmes RS, The genetics of alpha-hydroxyacid oxidase and alcohol dehydrogenase in the mouse: evidence for multiple gene loci and linkage between Hao-2 and Adh-3. Genetics. 1977 Dec;87(4):709-16
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory