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Hat1 Gene Detail
Summary
  • Symbol
    Hat1
  • Name
    histone aminotransferase 1
  • Synonyms
    2410071B14Rik, KAT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96013
    NCBI Gene: 107435
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:71219604-71271966 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 42.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1201 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96013
 protein coding gene Chr2:71219302-71271966 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025822
 protein coding gene Chr2:71490555-71552992 (+)
A/J MGP_AJ_G0025799
 protein coding gene Chr2:68696671-68748635 (+)
AKR/J MGP_AKRJ_G0025768
 protein coding gene Chr2:70579776-70635657 (+)
BALB/cJ MGP_BALBcJ_G0025794
 protein coding gene Chr2:68884306-68940350 (+)
C3H/HeJ MGP_C3HHeJ_G0025554
 protein coding gene Chr2:70785914-70840157 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026241
 protein coding gene Chr2:73646792-73708737 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023644
 protein coding gene Chr2:65924943-65972223 (+)
CAST/EiJ MGP_CASTEiJ_G0025018
 protein coding gene Chr2:70976668-71028966 (+)
CBA/J MGP_CBAJ_G0025534
 protein coding gene Chr2:76369424-76427968 (+)
DBA/2J MGP_DBA2J_G0025665
 protein coding gene Chr2:68334897-68390033 (+)
FVB/NJ MGP_FVBNJ_G0025628
 protein coding gene Chr2:67717874-67775144 (+)
LP/J MGP_LPJ_G0025754
 protein coding gene Chr2:71350690-71407313 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025657
 protein coding gene Chr2:78344611-78404817 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026298
 protein coding gene Chr2:70676468-70740051 (+)
PWK/PhJ MGP_PWKPhJ_G0024759
 protein coding gene Chr2:68206793-68257764 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024566
 protein coding gene Chr2:70873286-70931437 (+)
WSB/EiJ MGP_WSBEiJ_G0025086
 protein coding gene Chr2:71111960-71177193 (+)



Homology
more
  • Human Ortholog
    HAT1, histone acetyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HAT1, histone acetyltransferase 1
  • Synonyms
    KAT1
  • Links
    NCBI Gene ID: 8520
    neXtProt AC: NX_O14929
    UniProt: O14929

  • Chr Location
    2q31.1; chr2:171922448-171983686 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 2 alleles in 3 genetic backgrounds
    2 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit prenatal, perinatal and neonatal lethality, impaired lung maturation, respiratory failure, craniofacial defects, and reduced fibroblast proliferation. Heterozygotes show premature death, early-onset aging phenotypes including lordokyphosis, muscle atrophy, loss of subcutaneous fat and increased tumor incidence, and mitochondrial defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    21
  • cDNA Data
    110
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107435 NCBI Gene Model | MGI Sequence Detail 52363 C57BL/6J ±  kb
    transcript NM_026115 RefSeq | MGI Sequence Detail 1576 C57BL/6  
    polypeptide Q8BY71 UniProt | EBI | MGI Sequence Detail 416 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008452 histone acetyltransferase type B catalytic subunit
      (term hierarchy)
    • EC
      2.3.1.48
    • InterPro Domains
      IPR016181 Acyl-CoA N-acyltransferase
      IPR037113 Histone acetyl transferase 1, N-terminal domain superfamily
      IPR013523 Histone acetyltransferase HAT1, C-terminal
      IPR019467 Histone acetyl transferase HAT1 N-terminal
      IPR017380 Histone acetyltransferase type B, catalytic subunit
      IPR048776 Histone acetyltransferase type B catalytic subunit, C-terminal
    • GlyGen
      Q8BY71 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 110

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10621, MGD-MRK-10622, MGI:1914626, MGI:2138791
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:6128 Bulfield G, Genetic variation in the activity of the histidine catabolic enzymes between inbred strains of mice: a structural locus for a cytosol histidine aminotransferase isozyme (Hat-1). Biochem Genet. 1978 Dec;16(11-12):1233-41
    • Latest
      J:343198 Guo B, et al., Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging. Reprod Biol Endocrinol. 2023 Oct 31;21(1):103
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory