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Hba-a2 Gene Detail
Summary
  • Symbol
    Hba-a2
  • Name
    hemoglobin alpha, adult chain 2
  • Synonyms
    alpha 2 globin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96016
    NCBI Gene: 110257
  • Member of
    Hba cluster
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:32246489-32247298 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 18.87 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    5
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96016
 protein coding gene Chr11:32246489-32247310 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0016182
 protein coding gene Chr11:27863533-27864340 (+)
CAST/EiJ ENSTCUG00005028121
 protein coding gene Chr11:29076896-29077851 (+)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ ENSMUSG00205016171
 protein coding gene Chr11:29272986-29273795 (+)
JF1/MsJ no annotation
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190022471
 protein coding gene Chr11:29344686-29345495 (+)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    HBA1, hemoglobin subunit alpha 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HBA1, hemoglobin subunit alpha 1
  • Synonyms
    ECYT7, HBA-T3, HBH, METHBA
  • Links
    NCBI Gene ID: 3039
    UniProt: P69905

  • Chr Location
    16p13.3; chr16:176680-177522 (+)  GRCh38
  • Human Ortholog
    HBA2, hemoglobin subunit alpha 2
  • Synonyms
    ECYT7, HBA-T2, HBH
  • Links
    NCBI Gene ID: 3040
    UniProt: P69905

  • Chr Location
    16p13.3; chr16:172876-173710 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human HBA1,HBA2 associations

Human Disease Mouse Models
      
IDs
 View 7 models
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    282 phenotype references
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    8
  • Radiation induced
    3
  • Targeted
    2
  • Genomic Mutations
    6 involving Hba-a2
  • Find Mice (IMSR)
    7 strains or lines available
Homozygotes for a targeted deletion of both adult hemoglobin-alpha genes die in late gestation with symptoms resembling human hydrops fetalis.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    606
  • Tissues
    5
  • cDNA Data
    13
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000069917 Ensembl Gene Model | MGI Sequence Detail 810 C57BL/6J ±  kb
transcript ENSMUST00000093207 Ensembl | MGI Sequence Detail 554 Not Applicable  
polypeptide ENSMUSP00000090895 Ensembl | MGI Sequence Detail 142 Not Applicable  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 28
    Genomic 5
    cDNA 15
    Primer pair 2
    Other 6

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-10627
References
more
  • Summaries
    All 310
    Developmental Gene Expression 8
    Diseases 8
    Phenotypes 282
  • Earliest
    J:5500 Russell ES, et al., Genetics of mouse hemoglobins. Ann N Y Acad Sci. 1974 Nov 29;241(0):25-38
  • Latest
    J:388040 Benmhammed H, et al., PGC-1alpha agonism via oral administration of ZLN005 induces fetal hemoglobin and is antisickling in sickle mice. Blood Adv. 2026 Jun 23;10(12):4358-4369
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory