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Hba-x Gene Detail
Summary
  • Symbol
    Hba-x
  • Name
    hemoglobin X, alpha-like embryonic chain in Hba complex
  • Synonyms
    zeta globin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96019
    NCBI Gene: 15126
  • Member of
    Hba cluster
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:32226600-32228116 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 18.86 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    174 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96019
 protein coding gene Chr11:32226400-32228116 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018131
 protein coding gene Chr11:30481112-30482814 (+)
A/J MGP_AJ_G0018104
 protein coding gene Chr11:29324027-29325739 (+)
AKR/J MGP_AKRJ_G0018068
 protein coding gene Chr11:30253423-30255143 (+)
BALB/cJ MGP_BALBcJ_G0018073
 protein coding gene Chr11:29521010-29523842 (+)
C3H/HeJ MGP_C3HHeJ_G0017886
 protein coding gene Chr11:30199884-30201602 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018525
 protein coding gene Chr11:31487800-31489500 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016180
 protein coding gene Chr11:27856593-27858264 (+)
CAST/EiJ MGP_CASTEiJ_G0017448
 protein coding gene Chr11:30229688-30231474 (+)
CBA/J MGP_CBAJ_G0017859
 protein coding gene Chr11:32983016-32984803 (+)
DBA/2J MGP_DBA2J_G0017969
 protein coding gene Chr11:29122419-29124131 (+)
FVB/NJ MGP_FVBNJ_G0017963
 protein coding gene Chr11:28944669-28946417 (+)
LP/J MGP_LPJ_G0018041
 protein coding gene Chr11:30728030-30729771 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017987
 protein coding gene Chr11:33972833-33974539 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018566
 protein coding gene Chr11:30388865-30390587 (+)
PWK/PhJ MGP_PWKPhJ_G0017231
 protein coding gene Chr11:29273405-29275290 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017025
 protein coding gene Chr11:30075940-30086718 (+)
WSB/EiJ MGP_WSBEiJ_G0017501
 protein coding gene Chr11:30017038-30018752 (+)



Homology
more
  • Human Ortholog
    HBZ, hemoglobin subunit zeta
  • Vertebrate Orthologs
    10
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HBZ, hemoglobin subunit zeta
  • Synonyms
    HBAZ, HBZ1, HBZ-T1
  • Links
    NCBI Gene ID: 3050
    neXtProt AC: NX_P02008
    UniProt: P02008

  • Chr Location
    16p13.3; chr16:142728-154503 (+)  GRCh38
Human Diseases
less
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    153 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    5 involving Hba-x
  • Find Mice (IMSR)
    10 strains or lines available
Mice homozygous for a null allele show background sensitive prenatal lethality, variation in postnatal size and pallor, reduced litter size, and a thalassemia-like picture with anisocytosis, poikilocytosis, polychromasia, reduced mean corpuscular volume and hemoglobin, and increased platelet count.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    41
  • cDNA Data
    101
  • Literature Summary
    46
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 15126 NCBI Gene Model | MGI Sequence Detail 1517 C57BL/6J ±  kb
transcript NM_010405 RefSeq | MGI Sequence Detail 630 ZRU/MplStud  
polypeptide P06467 UniProt | EBI | MGI Sequence Detail 142 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 125
    Genomic 6
    cDNA 102
    Primer pair 12
    Other 5

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10631, MGI:2144168
References
more
  • Summaries
    All 232
    Developmental Gene Expression 46
    Diseases 7
    Gene Ontology 6
    Phenotypes 153
  • Earliest
    J:5686 Russell LB, et al., Radiation-induced mutations at mouse hemoglobin loci. Proc Natl Acad Sci U S A. 1976 Aug;73(8):2843-6
  • Latest
    J:355579 Kaminski TW, et al., Impaired hemoglobin clearance by sinusoidal endothelium promotes vaso-occlusion and liver injury in sickle cell disease. Haematologica. 2024 May 1;109(5):1535-1550
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory