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Hbb Complex/Cluster/Region Detail
Summary
  • Symbol
    Hbb
  • Name
    hemoglobin beta chain complex
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:96020
    NCBI Gene: 15127
  • Cluster Members
    Hbb-bt, Hbb-bs, Hbb-bh3 ... (10 members)
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 7, Syntenic
  • Mapping Data
    173 experiments
Strain
Comparison
more
  • PCR
    4
  • RFLP
    9
Human Diseases
more
  • Diseases
    1 with Hbb mouse models

Human Disease Mouse Models
      
IDs
 View 6 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    8 with disease annotations
  • References
    11 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 8 alleles in 7 genetic backgrounds
    109 phenotypes from multigenic genotypes
    3 images
    318 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or heterozygous for alleles of this gene exhibit varying degrees of hematopoietic defects.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    13
  • Tissues
    11
  • cDNA Data
    1
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 3
      cDNA 8
      Primer pair 6
      Other 2
    Other
    Accession IDs
    less
    MGD-MRK-10632
    References
    more
    • Summaries
      All 527
      Developmental Gene Expression 18
      Diseases 11
      Phenotypes 318
    • Earliest
      J:110 Popp RA, et al., Studies on the mouse hemoglobin locus. I. Identification of hemoglobin types and linkage of hemoglobin with albinism. J Hered. 1960;51(3):141-144
    • Latest
      J:355579 Kaminski TW, et al., Impaired hemoglobin clearance by sinusoidal endothelium promotes vaso-occlusion and liver injury in sickle cell disease. Haematologica. 2024 May 1;109(5):1535-1550
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    10/29/2024
    MGI 6.24     		The Jackson Laboratory