Hhex MGI Mouse Gene Detail - MGI:96086 - hematopoietically expressed homeobox

Symbol

Hhex
Name

hematopoietically expressed homeobox
Synonyms

Hex, Hex1, Hhex-rs2, Prhx

Feature Type

protein coding gene
IDs

MGI:96086
NCBI Gene: 15242
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:37423289-37429179 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 32.28 cM, cytoband D1
Mapping Data

8 experiments

SNPs within 2kb

206 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96086	protein coding gene	Chr19:37423258-37429179 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025081	protein coding gene	Chr19:36408965-36415148 (+)
A/J	MGP_AJ_G0025057	protein coding gene	Chr19:34651052-34655974 (+)
AKR/J	MGP_AKRJ_G0025025	protein coding gene	Chr19:35843135-35848054 (+)
BALB/cJ	MGP_BALBcJ_G0025055	protein coding gene	Chr19:34739614-34744532 (+)
C3H/HeJ	MGP_C3HHeJ_G0024814	protein coding gene	Chr19:35893508-35899077 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025496	protein coding gene	Chr19:37473920-37479922 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022915	protein coding gene	Chr19:34015555-34020514 (+)
CAST/EiJ	MGP_CASTEiJ_G0024281	protein coding gene	Chr19:35738787-35749313 (+)
CBA/J	MGP_CBAJ_G0024791	protein coding gene	Chr19:39209670-39214554 (+)
DBA/2J	MGP_DBA2J_G0024923	protein coding gene	Chr19:34504731-34509659 (+)
FVB/NJ	MGP_FVBNJ_G0024884	protein coding gene	Chr19:34315379-34320983 (+)
LP/J	MGP_LPJ_G0025009	protein coding gene	Chr19:36506451-36513177 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024915	protein coding gene	Chr19:39017895-39023508 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025554	protein coding gene	Chr19:35919168-35924087 (+)
PWK/PhJ	MGP_PWKPhJ_G0024033	protein coding gene	Chr19:34355596-34361562 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023833	protein coding gene	Chr19:34757315-34766734 (+)
WSB/EiJ	MGP_WSBEiJ_G0024348	protein coding gene	Chr19:36005429-36010323 (+)

Human Ortholog

HHEX, hematopoietically expressed homeobox

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HHEX, hematopoietically expressed homeobox
Synonyms

HEX, HMPH, HOX11L-PEN, PRH, PRHX
Links

HGNC:4901

NCBI Gene ID: 3087

neXtProt AC: NX_Q03014

UniProt: Q03014
Chr Location

10q23.33; chr10:92689955-92695647 (+) GRCh38

MGI Vertebrate Homology

Hhex stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HHEX
Gene Tree

Hhex

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Phenotype Summary

73 phenotypes from 7 alleles in 9 genetic backgrounds
7 phenotypes from multigenic genotypes
2 images
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

3
Targeted

15
Transgenic

2
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit embryonic lethality associated with abnormal embryogenesis and cardiac development. Mice homozygous for another knock-out allele exhibit embryonic lethality, fetal lethality and abnormal nervous system development.

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All GO Annotations

89
GO References

29

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1213
Tissues

270
cDNA Data

28
Literature Summary

171

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HHEX

Xenbase hhex

ZFIN hhex

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All Sequences

40
RefSeq

2
UniProt

2
CCDS

CCDS29778.1

Ensembl

ENSMUSG00000024986 (Evidence)
NCBI Gene

15242

			Length	Strain/Species	Flank
genomic	15242	NCBI Gene Model \| MGI Sequence Detail	5891	C57BL/6J	± kb
transcript	NM_008245	RefSeq \| MGI Sequence Detail	1771	C57BL/6
polypeptide	P43120	UniProt \| EBI \| MGI Sequence Detail	271	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008540 hematopoietically-expressed homeobox protein HHEX

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR051000 Homeobox DNA-binding

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

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All nucleic 59

Genomic 5

cDNA 31

Primer pair 10

Other 13

Microarray probesets 3

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MGD-MRK-10715, MGI:1201390, MGI:1277985

Summaries

All 242

Developmental Gene Expression 171

Gene Ontology 29

Phenotypes 33
Earliest

J:4210 Bedford FK, et al., HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human. Nucleic Acids Res. 1993 Mar 11;21(5):1245-9
Latest

J:352077 Kane E, et al., MicroRNA-7 regulates endocrine progenitor delamination and endocrine cell mass in developing pancreatic islets. iScience. 2024 Jul 19;27(7):110332

TSS for Hhex:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5494	Chr19:37423198-37423272 (+)	-54 bp
Tssr156218	Chr19:37423282-37423295 (+)	0 bp
Tssr156219	Chr19:37425069-37425073 (+)	1,782 bp
Tssr156220	Chr19:37425155-37425164 (+)	1,871 bp
Tssr156221	Chr19:37425180-37425196 (+)	1,899 bp
Tssr156222	Chr19:37428220-37428237 (+)	4,940 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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