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Hlf Gene Detail
Summary
  • Symbol
    Hlf
  • Name
    hepatic leukemia factor
  • Synonyms
    E230015K02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:96108
    NCBI Gene: 217082
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:90227362-90281721 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 55.03 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1619 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96108
 protein coding gene Chr11:90227361-90281745 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018938
 protein coding gene Chr11:92153886-92213333 (-)
A/J MGP_AJ_G0018906
 protein coding gene Chr11:88550604-88605809 (-)
AKR/J MGP_AKRJ_G0018876
 protein coding gene Chr11:91275195-91331226 (-)
BALB/cJ MGP_BALBcJ_G0018879
 protein coding gene Chr11:88998304-89053282 (-)
C3H/HeJ MGP_C3HHeJ_G0018693
 protein coding gene Chr11:91292397-91351044 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019331
 protein coding gene Chr11:95039965-95099083 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016962
 protein coding gene Chr11:85584290-85639908 (-)
CAST/EiJ MGP_CASTEiJ_G0018248
 protein coding gene Chr11:92035481-92093449 (-)
CBA/J MGP_CBAJ_G0018664
 protein coding gene Chr11:98988980-99048618 (-)
DBA/2J MGP_DBA2J_G0018772
 protein coding gene Chr11:88099113-88153823 (-)
FVB/NJ MGP_FVBNJ_G0018761
 protein coding gene Chr11:87613213-87668132 (-)
LP/J MGP_LPJ_G0018842
 protein coding gene Chr11:92676795-92732778 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018788
 protein coding gene Chr11:98860085-98916660 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019371
 protein coding gene Chr11:91523559-91580149 (-)
PWK/PhJ MGP_PWKPhJ_G0018018
 protein coding gene Chr11:88994664-89056969 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017808
 protein coding gene Chr11:91078268-91141934 (-)
WSB/EiJ MGP_WSBEiJ_G0018297
 protein coding gene Chr11:91389239-91446032 (-)



Homology
more
  • Human Ortholog
    HLF, HLF transcription factor, PAR bZIP family member
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLF, HLF transcription factor, PAR bZIP family member
  • Links
    NCBI Gene ID: 3131
    neXtProt AC: NX_Q16534
    UniProt: Q16534

  • Chr Location
    17q22; chr17:55264960-55325187 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotypes from multigenic genotypes
    32 phenotype references
Mice homozygous for a knock-out allele are viable, morphologically normal and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    827
  • Tissues
    110
  • cDNA Data
    62
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003949 Ensembl Gene Model | MGI Sequence Detail 54360 C57BL/6J ±  kb
transcript ENSMUST00000004051 Ensembl | MGI Sequence Detail 5642 Not Applicable  
polypeptide ENSMUSP00000004051 Ensembl | MGI Sequence Detail 295 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    cDNA 62
    Primer pair 1
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10742, MGI:2444586
References
more
  • Summaries
    All 70
    Developmental Gene Expression 12
    Diseases 1
    Gene Ontology 5
    Phenotypes 32
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:358168 Wang Y, et al., Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL-1R/TLR signals. EMBO Rep. 2023 Dec 6;24(12):e57485
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory