Hlx MGI Mouse Gene Detail - MGI:96109

Symbol

Hlx
Name

H2.0-like homeobox
Synonyms

Hlx1

Feature Type

protein coding gene
IDs

MGI:96109
NCBI Gene: 15284
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr1:184459340-184464690 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 88.97 cM
Mapping Data

5 experiments

SNPs within 2kb

182 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96109	protein coding gene	Chr1:184459337-184464816 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016908	protein coding gene	Chr1:191402501-191408855 (-)
A/J	MGP_AJ_G0016887	protein coding gene	Chr1:183604534-183609971 (-)
AKR/J	MGP_AKRJ_G0016852	protein coding gene	Chr1:189009059-189014440 (-)
BALB/cJ	MGP_BALBcJ_G0016845	protein coding gene	Chr1:184234956-184244123 (-)
C3H/HeJ	MGP_C3HHeJ_G0016669	protein coding gene	Chr1:189857084-189862559 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017308	protein coding gene	Chr1:197529411-197535723 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015015	protein coding gene	Chr1:174601805-174607516 (-)
CAST/EiJ	MGP_CASTEiJ_G0016252	protein coding gene	Chr1:189275290-189281817 (-)
CBA/J	MGP_CBAJ_G0016643	protein coding gene	Chr1:204904175-204910715 (-)
DBA/2J	MGP_DBA2J_G0016749	protein coding gene	Chr1:182365768-182371256 (-)
FVB/NJ	MGP_FVBNJ_G0016745	protein coding gene	Chr1:180465015-180470423 (-)
LP/J	MGP_LPJ_G0016824	protein coding gene	Chr1:192571633-192577197 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016777	protein coding gene	Chr1:211803569-211813888 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017345	protein coding gene	Chr1:188866641-188872199 (-)
PWK/PhJ	MGP_PWKPhJ_G0016039	protein coding gene	Chr1:181561236-181566758 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015815	protein coding gene	Chr1:187836782-187842144 (-)
WSB/EiJ	MGP_WSBEiJ_G0016314	protein coding gene	Chr1:189041005-189047367 (-)

Human Ortholog

HLX, H2.0 like homeobox

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HLX, H2.0 like homeobox
Synonyms

HB24, HLX1
Links

HGNC:4978

NCBI Gene ID: 3142

neXtProt AC: NX_Q14774

UniProt: Q14774
Chr Location

1q41; chr1:220879431-220885059 (+) GRCh38

MGI Vertebrate Homology

Hlx stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HLX
Gene Tree

Hlx

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Phenotype Summary

19 phenotypes from 1 allele in 3 genetic backgrounds
1 images
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disrputions in this gene die as embryos as a result of defective organogenesis and fetal hematopoiesis.

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All GO Annotations

23
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

945
Tissues

176
cDNA Data

21
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hlx

ZFIN hlx1

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All Sequences

39
RefSeq

2
UniProt

5
CCDS

CCDS15593.1

Ensembl

ENSMUSG00000039377 (Evidence)
NCBI Gene

15284

			Length	Strain/Species	Flank
genomic	15284	NCBI Gene Model \| MGI Sequence Detail	5351	C57BL/6J	± kb
transcript	NM_008250	RefSeq \| MGI Sequence Detail	2171	ZRU/MplStud
polypeptide	Q61670	UniProt \| EBI \| MGI Sequence Detail	476	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008620 H2.0-like homeobox protein

(term hierarchy)
InterPro Domains

IPR052497 H2.0 Homeobox Transcription Factors

IPR000047 Helix-turn-helix motif

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

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All nucleic 26

Genomic 3

cDNA 22

Primer pair 1

Microarray probesets 3

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MGD-MRK-10743

Summaries

All 48

Developmental Gene Expression 12

Gene Ontology 8

Phenotypes 7
Earliest

J:2276 Murtha MT, et al., Detection of homeobox genes in development and evolution. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10711-5
Latest

J:300359 Zhang H, et al., An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets. Cell Rep. 2020 Nov 24;33(8):108433

TSS for Hlx:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15647	Chr1:184464829-184464891 (-)	-170 bp
Tssr15646	Chr1:184464813-184464824 (-)	-129 bp
Tssr15645	Chr1:184464728-184464742 (-)	-45 bp
Tssr15644	Chr1:184464693-184464722 (-)	-18 bp
Tssr15643	Chr1:184464641-184464688 (-)	25 bp
Tssr15642	Chr1:184464625-184464636 (-)	59 bp
Tssr15641	Chr1:184464356-184464384 (-)	320 bp
Tssr15640	Chr1:184464326-184464346 (-)	354 bp
Tssr15639	Chr1:184464304-184464315 (-)	380 bp
Tssr15638	Chr1:184464133-184464146 (-)	550 bp
Tssr15637	Chr1:184464061-184464079 (-)	620 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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