Hmgb2 MGI Mouse Gene Detail - MGI:96157 - high mobility group box 2

Symbol

Hmgb2
Name

high mobility group box 2
Synonyms

Hmg2, HMG-2

Feature Type

protein coding gene
IDs

MGI:96157
NCBI Gene: 97165
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:57964941-57969033 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 29.90 cM
Mapping Data

5 experiments

SNPs within 2kb

174 from dbSNP Build 142
Strain Annotations

15
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96157	protein coding gene	Chr8:57964877-57969033 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033624	protein coding gene	Chr8:57245538-57251447 (+)
A/J	MGP_AJ_G0033606	protein coding gene	Chr8:54828291-54832903 (+)
AKR/J	MGP_AKRJ_G0033531	protein coding gene	Chr8:56455680-56461258 (+)
BALB/cJ	no annotation
C3H/HeJ	MGP_C3HHeJ_G0033312	protein coding gene	Chr8:57111604-57117921 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034119	protein coding gene	Chr8:59448728-59464460 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031067	protein coding gene	Chr8:50379877-50384064 (+)
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0033444	protein coding gene	Chr8:54636676-54640433 (+)
FVB/NJ	MGP_FVBNJ_G0033385	protein coding gene	Chr8:53992963-53998679 (+)
LP/J	MGP_LPJ_G0033532	protein coding gene	Chr8:57254119-57257069 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033429	protein coding gene	Chr8:63176688-63185217 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034137	protein coding gene	Chr8:56694274-56699093 (+)
PWK/PhJ	MGP_PWKPhJ_G0032346	protein coding gene	Chr8:53948981-53953162 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032182	protein coding gene	Chr8:55570127-55574819 (+)
WSB/EiJ	MGP_WSBEiJ_G0032754	protein coding gene	Chr8:56941412-56947079 (+)

Human Ortholog

HMGB2, high mobility group box 2

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HMGB2, high mobility group box 2
Synonyms

HMG2
Links

HGNC:5000

NCBI Gene ID: 3148

neXtProt AC: NX_P26583

UniProt: P26583
Chr Location

4q34.1; chr4:173331376-173334432 (-) GRCh38

MGI Vertebrate Homology

Hmgb2 stringent orthology
1 human;1 mouse;4 rat;2 zebrafish
HCOP

vertebrate homology predictions: HMGB2
Gene Tree

Hmgb2

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

2
Targeted

4
Genomic Mutations

1 involving Hmgb2
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for disruptions in this gene display reduced fertility. Female fertility is normal.

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All GO Annotations

93
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1185
Tissues

197
cDNA Data

26
Literature Summary

24

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hmgb2

ZFIN hmgb2a, hmgb2b

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All Sequences

57
RefSeq

8
UniProt

5
CCDS

CCDS40343.1

Ensembl

ENSMUSG00000054717 (Evidence)
NCBI Gene

97165

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054717	Ensembl Gene Model \| MGI Sequence Detail	4093	C57BL/6J	± kb
transcript	ENSMUST00000067925	Ensembl \| MGI Sequence Detail	2628	Not Applicable
polypeptide	ENSMUSP00000065940	Ensembl \| MGI Sequence Detail	210	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008631 high mobility group protein B2

(term hierarchy)
InterPro Domains

IPR009071 High mobility group box domain

IPR036910 High mobility group box domain superfamily

IPR050342 High Mobility Group Box (HMGB)

IPR017967 HMG box A DNA-binding domain, conserved site
GlyGen

P30681 1 site, 1 O-linked glycan (1 site)

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All nucleic 31

cDNA 27

Primer pair 3

Other 1

Microarray probesets 6

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MGD-MRK-10793, MGI:2140686

Summaries

All 86

Developmental Gene Expression 24

Gene Ontology 17

Phenotypes 18
Earliest

J:2642 Stolzenburg F, et al., Nucleotide sequence of a mouse cDNA encoding the non-histone chromosomal high mobility group protein-2 (HMG-2) [published erratum appears in Nucleic Acids Res 1992 Oct 11;20(19):5262]. Nucleic Acids Res. 1992 Sep 25;20(18):4927
Latest

J:345311 Ferguson CA, et al., Identification and characterization of Hand2 upstream genomic enhancers active in developing stomach and limbs. Dev Dyn. 2024 Feb;253(2):215-232

TSS for Hmgb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77433	Chr8:57964867-57964903 (+)	-56 bp
Tssr2571	Chr8:57964915-57964918 (+)	-24 bp
Tssr77434	Chr8:57964927-57964964 (+)	5 bp
Tssr77435	Chr8:57965555-57965601 (+)	637 bp
Tssr77436	Chr8:57965879-57965928 (+)	963 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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