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Hoxa4 Gene Detail
Summary
  • Symbol
    Hoxa4
  • Name
    homeobox A4
  • Synonyms
    Hox-1.4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96176
    NCBI Gene: 15401
  • Member of
    Hoxa cluster
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:52166662-52168683 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 25.40 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96176
 protein coding gene Chr6:52166651-52168733 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030743
 protein coding gene Chr6:51428440-51430498 (-)
A/J MGP_AJ_G0030712
 protein coding gene Chr6:49025274-49027356 (-)
AKR/J MGP_AKRJ_G0030639
 protein coding gene Chr6:50732156-50734238 (-)
BALB/cJ MGP_BALBcJ_G0030724
 protein coding gene Chr6:49384711-49387098 (-)
C3H/HeJ MGP_C3HHeJ_G0030437
 protein coding gene Chr6:50739914-50741996 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031179
 protein coding gene Chr6:52566022-52568088 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028386
 protein coding gene Chr6:46673200-46675276 (-)
CAST/EiJ MGP_CASTEiJ_G0029840
 protein coding gene Chr6:50553121-50555203 (-)
CBA/J MGP_CBAJ_G0030411
 protein coding gene Chr6:54764225-54766283 (-)
DBA/2J MGP_DBA2J_G0030561
 protein coding gene Chr6:48948022-48950104 (-)
FVB/NJ MGP_FVBNJ_G0030513
 protein coding gene Chr6:48558091-48559896 (-)
LP/J MGP_LPJ_G0030646
 protein coding gene Chr6:51409675-51411612 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030547
 protein coding gene Chr6:57394925-57397007 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031209
 protein coding gene Chr6:50659994-50662076 (-)
PWK/PhJ MGP_PWKPhJ_G0029553
 protein coding gene Chr6:48571140-48573222 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029387
 protein coding gene Chr6:49994521-49996597 (-)
WSB/EiJ MGP_WSBEiJ_G0029917
 protein coding gene Chr6:50675394-50677476 (-)



Homology
more
  • Human Ortholog
    HOXA4, homeobox A4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXA4, homeobox A4
  • Synonyms
    HOX1, HOX1D
  • Links
    NCBI Gene ID: 3201
    neXtProt AC: NX_Q00056
    UniProt: Q00056

  • Chr Location
    7p15.2; chr7:27128507-27130780 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    3 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to homeotic transformation of cervical vertebrae. Mice homozygous for a knock-out allele also exhibit a hunched appearance of the pectoral girdle. Mice homozygous for a different knock-out allele show additionalsternal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1056
  • Tissues
    182
  • cDNA Data
    27
  • Literature Summary
    74
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15401 NCBI Gene Model | MGI Sequence Detail 2022 C57BL/6J ±  kb
    transcript NM_008265 RefSeq | MGI Sequence Detail 1546 ZRU/MplStud  
    polypeptide P06798 UniProt | EBI | MGI Sequence Detail 285 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 12
      cDNA 29
      Primer pair 7
      Other 12

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-10820, MGD-MRK-10877, MGI:2141624
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 74
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:8339 Rubin MR, et al., A mouse homeo box gene is expressed in spermatocytes and embryos. Science. 1986 Aug 8;233(4764):663-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory