Hoxb2 MGI Mouse Gene Detail - MGI:96183

Symbol

Hoxb2
Name

homeobox B2
Synonyms

Hox-2.8, Hoxbes2

Feature Type

protein coding gene
IDs

MGI:96183
NCBI Gene: 103889
Member of

Hoxb cluster
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr11:96242458-96244846 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 59.85 cM
Mapping Data

5 experiments

SNPs within 2kb

122 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96183	protein coding gene	Chr11:96241351-96244846 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019008	protein coding gene	Chr11:98663614-98667132 (+)
A/J	MGP_AJ_G0018976	protein coding gene	Chr11:94635000-94638477 (+)
AKR/J	MGP_AKRJ_G0018946	protein coding gene	Chr11:97561794-97565347 (+)
BALB/cJ	MGP_BALBcJ_G0018949	protein coding gene	Chr11:95134487-95138548 (+)
C3H/HeJ	MGP_C3HHeJ_G0018763	protein coding gene	Chr11:97692438-97695944 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019401	protein coding gene	Chr11:101744564-101748118 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017031	protein coding gene	Chr11:92121804-92125286 (+)
CAST/EiJ	MGP_CASTEiJ_G0018316	protein coding gene	Chr11:98517959-98521433 (+)
CBA/J	MGP_CBAJ_G0018734	protein coding gene	Chr11:105909240-105912717 (+)
DBA/2J	MGP_DBA2J_G0018842	protein coding gene	Chr11:94202443-94205934 (+)
FVB/NJ	MGP_FVBNJ_G0018831	protein coding gene	Chr11:93681077-93684562 (+)
LP/J	MGP_LPJ_G0018912	protein coding gene	Chr11:99199533-99203022 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018858	protein coding gene	Chr11:105904624-105908120 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019441	protein coding gene	Chr11:97868624-97872111 (+)
PWK/PhJ	MGP_PWKPhJ_G0018088	protein coding gene	Chr11:95154467-95158069 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017877	protein coding gene	Chr11:97596162-97599645 (+)
WSB/EiJ	MGP_WSBEiJ_G0018366	protein coding gene	Chr11:97758544-97762046 (+)

Human Ortholog

HOXB2, homeobox B2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HOXB2, homeobox B2
Synonyms

HOX2, Hox-2.8, HOX2H, K8
Links

HGNC:5113

NCBI Gene ID: 3212

neXtProt AC: NX_P14652

UniProt: P14652
Chr Location

17q21.32; chr17:48540894-48545109 (-) GRCh38

MGI Vertebrate Homology

Hoxb2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HOXB2
Gene Tree

Hoxb2

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Phenotype Summary

34 phenotypes from 6 alleles in 4 genetic backgrounds
10 phenotypes from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

1
Gene trapped

2
Targeted

12
Genomic Mutations

3 involving Hoxb2
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a reporter allele die neonatally with altered segmental identity and abnormal migration of motor neurons in the hindbrain. Mice homozygous for null alleles can exhibit partial postnatal lethality, narrow face, runting, absent facial motor nuclei, and facial nerve/muscle defects.

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All GO Annotations

38
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1056
Tissues

160
cDNA Data

17
Literature Summary

60

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HOXB2

Xenbase hoxb2

ZFIN hoxb2a

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All Sequences

36
RefSeq

4
UniProt

1
CCDS

CCDS36290.1

Ensembl

ENSMUSG00000075588 (Evidence)
NCBI Gene

103889

			Length	Strain/Species	Flank
genomic	103889	NCBI Gene Model \| MGI Sequence Detail	2389	C57BL/6J	± kb
transcript	NM_134032	RefSeq \| MGI Sequence Detail	1631	ZRU/MplStud
polypeptide	P0C1T1	UniProt \| EBI \| MGI Sequence Detail	354	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008699 homeobox protein Hox-B2

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

IPR001827 Homeobox protein, antennapedia type, conserved site

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All nucleic 40

Genomic 4

cDNA 21

Primer pair 5

Other 10

Microarray probesets 3

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MGD-MRK-10836, MGD-MRK-10884, MGI:2144329

Summaries

All 112

Developmental Gene Expression 60

Gene Ontology 7

Phenotypes 23
Earliest

J:32270 Wilkinson DG, et al., Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain. Nature. 1989 Oct 5;341(6241):405-9
Latest

J:333802 Singh N, et al., LHX2 in germ cells control tubular organization in the developing mouse testis. Exp Cell Res. 2023 Feb 14;425(1):113511

TSS for Hoxb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104519	Chr11:96242422-96242461 (+)	-16 bp
Tssr104520	Chr11:96242695-96242700 (+)	240 bp
Tssr104521	Chr11:96242724-96242734 (+)	271 bp
Tssr104522	Chr11:96242776-96242794 (+)	327 bp
Tssr104523	Chr11:96242800-96242844 (+)	364 bp
Tssr104524	Chr11:96242880-96242896 (+)	430 bp
Tssr104525	Chr11:96242946-96242964 (+)	497 bp
Tssr104526	Chr11:96243690-96243707 (+)	1,241 bp
Tssr104527	Chr11:96243712-96243726 (+)	1,261 bp
Tssr104528	Chr11:96243901-96243912 (+)	1,449 bp
Tssr104529	Chr11:96243953-96243966 (+)	1,502 bp
Tssr104530	Chr11:96243981-96243990 (+)	1,528 bp
Tssr104531	Chr11:96244150-96244168 (+)	1,701 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24