Hoxb5 MGI Mouse Gene Detail - MGI:96186

Symbol

Hoxb5
Name

homeobox B5
Synonyms

Hox-2.1

Feature Type

protein coding gene
IDs

MGI:96186
NCBI Gene: 15413
Member of

Hoxb cluster
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr11:96194338-96196947 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 59.82 cM
Mapping Data

17 experiments

SNPs within 2kb

50 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96186	protein coding gene	Chr11:96194162-96196947 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019005	protein coding gene	Chr11:98615043-98617828 (+)
A/J	MGP_AJ_G0018973	protein coding gene	Chr11:94587932-94590715 (+)
AKR/J	MGP_AKRJ_G0018943	protein coding gene	Chr11:97514021-97516804 (+)
BALB/cJ	MGP_BALBcJ_G0018946	protein coding gene	Chr11:95087620-95090405 (+)
C3H/HeJ	MGP_C3HHeJ_G0018760	protein coding gene	Chr11:97645333-97648118 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019398	protein coding gene	Chr11:101697601-101700386 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017028	protein coding gene	Chr11:92074502-92077260 (+)
CAST/EiJ	MGP_CASTEiJ_G0018313	protein coding gene	Chr11:98467364-98471763 (+)
CBA/J	MGP_CBAJ_G0018731	protein coding gene	Chr11:105859398-105862181 (+)
DBA/2J	MGP_DBA2J_G0018839	protein coding gene	Chr11:94155369-94158154 (+)
FVB/NJ	MGP_FVBNJ_G0018828	protein coding gene	Chr11:93634108-93636887 (+)
LP/J	MGP_LPJ_G0018909	protein coding gene	Chr11:99152540-99155325 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018855	protein coding gene	Chr11:105855077-105857862 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019438	protein coding gene	Chr11:97821557-97824342 (+)
PWK/PhJ	MGP_PWKPhJ_G0018085	protein coding gene	Chr11:95106692-95109476 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017874	protein coding gene	Chr11:97548022-97550803 (+)
WSB/EiJ	MGP_WSBEiJ_G0018363	protein coding gene	Chr11:97707838-97710623 (+)

Human Ortholog

HOXB5, homeobox B5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HOXB5, homeobox B5
Synonyms

HHO.C10, HOX2, Hox2.1, HOX2A, HU-1
Links

HGNC:5116

NCBI Gene ID: 3215

neXtProt AC: NX_P09067

UniProt: P09067
Chr Location

17q21.32; chr17:48591257-48593779 (-) GRCh38

MGI Vertebrate Homology

Hoxb5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HOXB5
Gene Tree

Hoxb5

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Phenotype Summary

19 phenotypes from 2 alleles in 3 genetic backgrounds
14 phenotypes from multigenic genotypes
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Gene trapped

1
Targeted

5
Transgenic

1
Genomic Mutations

3 involving Hoxb5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and fertile but exhibit a rostral shift of the shoulder girdle resulting in altered position of the forelimbs, and show variable anteriorizing homeotic transformations of cervicothoracic vertrebrae C6 through T1.

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All GO Annotations

43
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1316
Tissues

358
cDNA Data

38
Literature Summary

96

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HOXB5

Xenbase hoxb5

ZFIN hoxb5a, hoxb5b

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS25296.1

Ensembl

ENSMUSG00000038700 (Evidence)
NCBI Gene

15413

			Length	Strain/Species	Flank
genomic	15413	NCBI Gene Model \| MGI Sequence Detail	2610	C57BL/6J	± kb
transcript	NM_008268	RefSeq \| MGI Sequence Detail	1912	ZRU/MplStud
polypeptide	P09079	UniProt \| EBI \| MGI Sequence Detail	269	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008702 homeobox protein Hox-B5

(term hierarchy)
InterPro Domains

IPR050296 Antennapedia-type homeobox

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

IPR017995 Homeobox protein, antennapedia type

IPR001827 Homeobox protein, antennapedia type, conserved site

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All nucleic 78

Genomic 18

cDNA 40

Primer pair 9

Other 11

Microarray probesets 3

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MGD-MRK-10829, MGD-MRK-10887, MGI:2144140

Summaries

All 168

Developmental Gene Expression 96

Gene Ontology 10

Phenotypes 29
Earliest

J:8076 Jackson IJ, et al., A mouse homoeo box gene is expressed during embryogenesis and in adult kidney. Nature. 1985 Oct 24-30;317(6039):745-8
Latest

J:354191 Kc R, et al., Multimodal Hox5 activity generates motor neuron diversity. Commun Biol. 2024 Sep 17;7(1):1166

TSS for Hoxb5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104489	Chr11:96194333-96194377 (+)	17 bp
Tssr104490	Chr11:96194380-96194387 (+)	46 bp
Tssr104491	Chr11:96194399-96194406 (+)	65 bp
Tssr104492	Chr11:96194417-96194431 (+)	86 bp
Tssr104493	Chr11:96194440-96194459 (+)	112 bp
Tssr104494	Chr11:96194476-96194544 (+)	172 bp
Tssr104495	Chr11:96194551-96194585 (+)	230 bp
Tssr104496	Chr11:96194723-96194742 (+)	395 bp
Tssr104497	Chr11:96194850-96194867 (+)	521 bp
Tssr104498	Chr11:96194881-96194900 (+)	553 bp
Tssr104499	Chr11:96194906-96194918 (+)	574 bp
Tssr104500	Chr11:96194948-96194965 (+)	619 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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