Hoxb7 MGI Mouse Gene Detail - MGI:96188

Symbol

Hoxb7
Name

homeobox B7
Synonyms

Hox-2.3

Feature Type

protein coding gene
IDs

MGI:96188
NCBI Gene: 15415
Member of

Hoxb cluster
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:96177449-96180988 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 59.82 cM
Mapping Data

30 experiments

SNPs within 2kb

109 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96188	protein coding gene	Chr11:96176431-96180989 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019003	protein coding gene	Chr11:98598638-98601976 (+)
A/J	MGP_AJ_G0018971	protein coding gene	Chr11:94571484-94574824 (+)
AKR/J	MGP_AKRJ_G0018941	protein coding gene	Chr11:97497121-97500667 (+)
BALB/cJ	MGP_BALBcJ_G0018944	protein coding gene	Chr11:95070987-95074498 (+)
C3H/HeJ	MGP_C3HHeJ_G0018758	protein coding gene	Chr11:97629048-97632567 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019396	protein coding gene	Chr11:101680988-101684517 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017026	protein coding gene	Chr11:92057891-92061382 (+)
CAST/EiJ	MGP_CASTEiJ_G0018311	protein coding gene	Chr11:98449913-98454194 (+)
CBA/J	MGP_CBAJ_G0018729	protein coding gene	Chr11:105842673-105845995 (+)
DBA/2J	MGP_DBA2J_G0018837	protein coding gene	Chr11:94138429-94141932 (+)
FVB/NJ	MGP_FVBNJ_G0018826	protein coding gene	Chr11:93617609-93620924 (+)
LP/J	MGP_LPJ_G0018907	protein coding gene	Chr11:99135955-99139450 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018853	protein coding gene	Chr11:105838593-105842078 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019436	protein coding gene	Chr11:97804661-97808360 (+)
PWK/PhJ	MGP_PWKPhJ_G0018083	protein coding gene	Chr11:95089993-95093377 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017872	protein coding gene	Chr11:97530894-97534150 (+)
WSB/EiJ	MGP_WSBEiJ_G0018361	protein coding gene	Chr11:97689988-97693797 (+)

Human Ortholog

HOXB7, homeobox B7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HOXB7, homeobox B7
Synonyms

HHO.C1, HOX2, Hox-2.3, HOX2C
Links

HGNC:5118

NCBI Gene ID: 3217

neXtProt AC: NX_P09629

UniProt: P09629
Chr Location

17q21.32; chr17:48607232-48633572 (-) GRCh38

MGI Vertebrate Homology

Hoxb7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HOXB7
Gene Tree

Hoxb7

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Phenotype Summary

14 phenotypes from 3 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Targeted

6
Transgenic

2
Genomic Mutations

3 involving Hoxb7
Incidental Mutations

APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygotes for a targeted null mutation exhibit first and second rib defects.

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All GO Annotations

40
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

989
Tissues

194
cDNA Data

20
Literature Summary

45

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hoxb7

ZFIN hoxb7a

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All Sequences

32
RefSeq

4
UniProt

1
CCDS

CCDS25294.1

Ensembl

ENSMUSG00000038721 (Evidence)
NCBI Gene

15415

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038721	Ensembl Gene Model \| MGI Sequence Detail	3540	C57BL/6J	± kb
transcript	ENSMUST00000049352	Ensembl \| MGI Sequence Detail	1291	Not Applicable
polypeptide	ENSMUSP00000040121	Ensembl \| MGI Sequence Detail	217	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008704 homeobox protein Hox-B7

(term hierarchy)
InterPro Domains

IPR050948 Antp homeobox transcription factor

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

IPR017995 Homeobox protein, antennapedia type

IPR001827 Homeobox protein, antennapedia type, conserved site

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All nucleic 55

Genomic 18

cDNA 25

Primer pair 8

Other 4

Microarray probesets 2

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MGD-MRK-10831, MGD-MRK-10889, MGI:2144127

Summaries

All 126

Developmental Gene Expression 45

Gene Ontology 8

Phenotypes 16
Earliest

J:8129 Hart CP, et al., Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
Latest

J:348704 Vong KI, et al., Risk of meningomyelocele mediated by the common 22q11.2 deletion. Science. 2024 May 3;384(6695):584-590

TSS for Hoxb7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104471	Chr11:96175598-96175612 (+)	-1,844 bp
Tssr104472	Chr11:96176053-96176056 (+)	-1,394 bp
Tssr104473	Chr11:96176394-96176417 (+)	-1,043 bp
Tssr104474	Chr11:96176419-96176453 (+)	-1,013 bp
Tssr104475	Chr11:96177464-96177479 (+)	23 bp
Tssr104476	Chr11:96177604-96177617 (+)	162 bp
Tssr104477	Chr11:96177882-96177905 (+)	445 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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