Hoxb8 MGI Mouse Gene Detail - MGI:96189

Symbol

Hoxb8
Name

homeobox B8
Synonyms

Hox-2.4

Feature Type

protein coding gene
IDs

MGI:96189
NCBI Gene: 15416
Member of

Hoxb cluster
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr11:96172731-96176141 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 59.82 cM
Mapping Data

3 experiments

SNPs within 2kb

66 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96189	protein coding gene	Chr11:96170227-96176151 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019002	protein coding gene	Chr11:98592198-98595477 (+)
A/J	MGP_AJ_G0018970	protein coding gene	Chr11:94566803-94570211 (+)
AKR/J	MGP_AKRJ_G0018940	protein coding gene	Chr11:97492437-97495848 (+)
BALB/cJ	MGP_BALBcJ_G0018943	protein coding gene	Chr11:95062055-95065334 (+)
C3H/HeJ	MGP_C3HHeJ_G0018757	protein coding gene	Chr11:97623298-97626734 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019395	protein coding gene	Chr11:101671865-101679698 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017025	protein coding gene	Chr11:92053180-92056596 (+)
CAST/EiJ	MGP_CASTEiJ_G0018310	protein coding gene	Chr11:98443772-98447175 (+)
CBA/J	MGP_CBAJ_G0018728	protein coding gene	Chr11:105838037-105841400 (+)
DBA/2J	MGP_DBA2J_G0018836	protein coding gene	Chr11:94133715-94137125 (+)
FVB/NJ	MGP_FVBNJ_G0018825	protein coding gene	Chr11:93612684-93616094 (+)
LP/J	MGP_LPJ_G0018906	protein coding gene	Chr11:99130338-99133756 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018852	protein coding gene	Chr11:105833672-105837273 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019435	protein coding gene	Chr11:97799223-97802645 (+)
PWK/PhJ	MGP_PWKPhJ_G0018082	protein coding gene	Chr11:95084660-95088673 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017871	protein coding gene	Chr11:97526306-97529602 (+)
WSB/EiJ	MGP_WSBEiJ_G0018360	protein coding gene	Chr11:97685336-97688692 (+)

Human Ortholog

HOXB8, homeobox B8

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HOXB8, homeobox B8
Synonyms

HOX2, Hox-2.4, HOX2D
Links

HGNC:5119

NCBI Gene ID: 3218

neXtProt AC: NX_P17481

UniProt: P17481
Chr Location

17q21.32; chr17:48611377-48615292 (-) GRCh38

MGI Vertebrate Homology

Hoxb8 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HOXB8
Gene Tree

Hoxb8

Diseases

1 with Hoxb8 mouse models

Human Disease

Mouse Models

trichotillomania

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

30 phenotypes from 8 alleles in 6 genetic backgrounds
7 phenotypes from multigenic genotypes
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

4
Targeted

13
Genomic Mutations

3 involving Hoxb8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Most homozygotes for targeted null mutations exhibit delayed preweaning growth, degeneration of the second spinal ganglion, axial skeletal defects, impaired clasping, an altered gait, and excessive grooming.

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All GO Annotations

43
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1106
Tissues

238
cDNA Data

15
Literature Summary

83

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HOXB8

Xenbase hoxb8

ZFIN hoxb8a, hoxb8b

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All Sequences

45
RefSeq

10
UniProt

3
CCDS

CCDS25293.1

Ensembl

ENSMUSG00000056648 (Evidence)
NCBI Gene

15416

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056648	Ensembl Gene Model \| MGI Sequence Detail	3411	C57BL/6J	± kb
transcript	ENSMUST00000052650	Ensembl \| MGI Sequence Detail	2635	Not Applicable
polypeptide	ENSMUSP00000052496	Ensembl \| MGI Sequence Detail	243	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008705 homeobox protein Hox-B8

(term hierarchy)
InterPro Domains

IPR050948 Antp homeobox transcription factor

IPR000047 Helix-turn-helix motif

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

IPR017995 Homeobox protein, antennapedia type

IPR001827 Homeobox protein, antennapedia type, conserved site

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All nucleic 46

Genomic 13

cDNA 16

Primer pair 6

Other 11

Microarray probesets 4

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MGD-MRK-10832, MGD-MRK-10890

Summaries

All 155

Developmental Gene Expression 83

Diseases 1

Gene Ontology 15

Phenotypes 30
Earliest

J:8129 Hart CP, et al., Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
Latest

J:339474 Bohic M, et al., A new Hoxb8FlpO mouse line for intersectional approaches to dissect developmentally defined adult sensorimotor circuits. Front Mol Neurosci. 2023;16:1176823

TSS for Hoxb8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104458	Chr11:96173057-96173068 (+)	332 bp
Tssr104459	Chr11:96173178-96173237 (+)	477 bp
Tssr104460	Chr11:96173240-96173257 (+)	518 bp
Tssr104461	Chr11:96173355-96173380 (+)	637 bp
Tssr104462	Chr11:96173474-96173547 (+)	780 bp
Tssr104463	Chr11:96173562-96173577 (+)	839 bp
Tssr104464	Chr11:96173794-96173820 (+)	1,076 bp
Tssr104465	Chr11:96173849-96173866 (+)	1,127 bp
Tssr104466	Chr11:96174088-96174115 (+)	1,371 bp
Tssr104467	Chr11:96174874-96174901 (+)	2,157 bp
Tssr104468	Chr11:96174905-96174919 (+)	2,181 bp
Tssr104469	Chr11:96174962-96175029 (+)	2,265 bp
Tssr104470	Chr11:96175049-96175068 (+)	2,328 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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