Hoxc12 MGI Mouse Gene Detail - MGI:96194

Symbol

Hoxc12
Name

homeobox C12
Synonyms

Hox-3.8

Feature Type

protein coding gene
IDs

MGI:96194
NCBI Gene: 15421
Member of

Hoxc cluster
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:102845261-102847044 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 58.01 cM
Mapping Data

4 experiments

SNPs within 2kb

76 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96194	protein coding gene	Chr15:102845192-102847044 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022425	protein coding gene	Chr15:105171008-105172869 (+)
A/J	MGP_AJ_G0022387	protein coding gene	Chr15:101015534-101017395 (+)
AKR/J	MGP_AKRJ_G0022362	protein coding gene	Chr15:104084755-104086600 (+)
BALB/cJ	MGP_BALBcJ_G0022391	protein coding gene	Chr15:101063149-101065010 (+)
C3H/HeJ	MGP_C3HHeJ_G0022158	protein coding gene	Chr15:104160867-104162728 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022840	protein coding gene	Chr15:109067042-109068894 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020363	protein coding gene	Chr15:96785073-96786926 (+)
CAST/EiJ	MGP_CASTEiJ_G0021684	protein coding gene	Chr15:105033087-105034937 (+)
CBA/J	MGP_CBAJ_G0022127	protein coding gene	Chr15:112898305-112900166 (+)
DBA/2J	MGP_DBA2J_G0022258	protein coding gene	Chr15:100285654-100287502 (+)
FVB/NJ	MGP_FVBNJ_G0022234	protein coding gene	Chr15:99355129-99356977 (+)
LP/J	MGP_LPJ_G0022327	protein coding gene	Chr15:105306636-105308497 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022256	protein coding gene	Chr15:116414933-116416781 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022852	protein coding gene	Chr15:104123495-104125347 (+)
PWK/PhJ	MGP_PWKPhJ_G0021424	protein coding gene	Chr15:100464568-100466369 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021256	protein coding gene	Chr15:103953441-103955300 (+)
WSB/EiJ	MGP_WSBEiJ_G0021734	protein coding gene	Chr15:104737855-104739709 (+)

Human Ortholog

HOXC12, homeobox C12

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HOXC12, homeobox C12
Synonyms

HOC3F, HOX3, HOX3F
Links

HGNC:5124

NCBI Gene ID: 3228

neXtProt AC: NX_P31275

UniProt: P31275
Chr Location

12q13.13; chr12:53954903-53958956 (+) GRCh38

MGI Vertebrate Homology

Hoxc12 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HOXC12
Gene Tree

Hoxc12

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

2
Targeted

5
Genomic Mutations

4 involving Hoxc12
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

14 strains or lines available

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All GO Annotations

6
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

785
Tissues

65
cDNA Data

7
Literature Summary

19

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hoxc12

ZFIN hoxc12b

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS27891.1

Ensembl

ENSMUSG00000050328 (Evidence)
NCBI Gene

15421

			Length	Strain/Species	Flank
genomic	15421	NCBI Gene Model \| MGI Sequence Detail	1784	C57BL/6J	± kb
transcript	NM_010463	RefSeq \| MGI Sequence Detail	962	Not Specified
polypeptide	Q8K5B8	UniProt \| EBI \| MGI Sequence Detail	280	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008709 homeobox protein Hox-C12

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

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All nucleic 21

Genomic 6

cDNA 8

Primer pair 4

Other 3

Microarray probesets 1

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MGD-MRK-10846, MGD-MRK-10895

Summaries

All 72

Developmental Gene Expression 19

Diseases 1

Gene Ontology 6

Phenotypes 34
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hoxc12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133475	Chr15:102845251-102845269 (+)	-1 bp
Tssr133476	Chr15:102845277-102845289 (+)	22 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24