Hoxd10 MGI Mouse Gene Detail - MGI:96202

Symbol

Hoxd10
Name

homeobox D10
Synonyms

Hox-4.5, Hox-5.3

Feature Type

protein coding gene
IDs

MGI:96202
NCBI Gene: 15430
Member of

Hoxd cluster
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:74522268-74525449 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 44.13 cM
Mapping Data

9 experiments

SNPs within 2kb

59 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96202	protein coding gene	Chr2:74514617-74525450 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025848	protein coding gene	Chr2:75006128-75009281 (+)
A/J	MGP_AJ_G0025826	protein coding gene	Chr2:72073253-72076406 (+)
AKR/J	MGP_AKRJ_G0025794	protein coding gene	Chr2:74026475-74029626 (+)
BALB/cJ	MGP_BALBcJ_G0025820	protein coding gene	Chr2:72259893-72263046 (+)
C3H/HeJ	MGP_C3HHeJ_G0025580	protein coding gene	Chr2:74214287-74217468 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026267	protein coding gene	Chr2:77240253-77243422 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023670	protein coding gene	Chr2:69496403-69499628 (+)
CAST/EiJ	MGP_CASTEiJ_G0025044	protein coding gene	Chr2:74531284-74534454 (+)
CBA/J	MGP_CBAJ_G0025561	protein coding gene	Chr2:80061402-80064571 (+)
DBA/2J	MGP_DBA2J_G0025692	protein coding gene	Chr2:71679800-71682963 (+)
FVB/NJ	MGP_FVBNJ_G0025654	protein coding gene	Chr2:71069518-71072671 (+)
LP/J	MGP_LPJ_G0025780	protein coding gene	Chr2:74870261-74873414 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025685	protein coding gene	Chr2:81975038-81978191 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026324	protein coding gene	Chr2:74141979-74145158 (+)
PWK/PhJ	MGP_PWKPhJ_G0024785	protein coding gene	Chr2:71610408-71613651 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024593	protein coding gene	Chr2:74375793-74378952 (+)
WSB/EiJ	MGP_WSBEiJ_G0025112	protein coding gene	Chr2:74577948-74581101 (+)

Human Ortholog

HOXD10, homeobox D10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HOXD10, homeobox D10
Synonyms

HOX4, Hox-4.4, HOX4D, HOX4E
Links

HGNC:5133

NCBI Gene ID: 3236

neXtProt AC: NX_P28358

UniProt: P28358
Chr Location

2q31.1; chr2:176108790-176119937 (+) GRCh38

MGI Vertebrate Homology

Hoxd10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HOXD10
Gene Tree

Hoxd10

Diseases

1 with human HOXD10 associations

				Human Disease	Mouse Models
				congenital vertical talus IDs congenital vertical talus DOID:0111568 MESH:D005413 OMIM:192950 ORDO:178382 UMLS_CUI:C0240912

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
37 phenotypes from multigenic genotypes
76 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Spontaneous

1
Targeted

36
Genomic Mutations

36 involving Hoxd10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit an abnormal gait associated with defects in sacral vertebrae (including homeotic transformations), hindlimb bones, and muscle innervation. These defects are sometimes seen in heterozygotes as well.

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All GO Annotations

41
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1198
Tissues

247
cDNA Data

19
Literature Summary

120

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HOXD10

Xenbase LOC116406456

ZFIN hoxd10a

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All Sequences

33
RefSeq

4
UniProt

1
CCDS

CCDS16141.1

Ensembl

ENSMUSG00000050368 (Evidence)
NCBI Gene

15430

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050368	Ensembl Gene Model \| MGI Sequence Detail	3182	C57BL/6J	± kb
transcript	ENSMUST00000061745	Ensembl \| MGI Sequence Detail	1816	Not Applicable
polypeptide	ENSMUSP00000062412	Ensembl \| MGI Sequence Detail	340	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008717 homeobox protein Hox-D10

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

IPR046333 Homeobox protein Hox-A10/abdominal-B-like

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All nucleic 56

Genomic 12

cDNA 23

Primer pair 9

Other 12

Microarray probesets 3

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MGD-MRK-10852, MGD-MRK-10860, MGD-MRK-10903, MGI:2138919, MGI:2139108

Summaries

All 203

Developmental Gene Expression 120

Gene Ontology 13

Phenotypes 76
Earliest

J:9951 Duboule D, et al., The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes. EMBO J. 1989 May;8(5):1497-505
Latest

J:342014 Chen Y, et al., Hnrnpk is essential for embryonic limb bud development as a transcription activator and a collaborator of insulator protein Ctcf. Cell Death Differ. 2023 Oct;30(10):2293-2308

TSS for Hoxd10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18406	Chr2:74522204-74522213 (+)	-59 bp
Tssr18407	Chr2:74522229-74522240 (+)	-33 bp
Tssr18408	Chr2:74522257-74522284 (+)	3 bp
Tssr18409	Chr2:74522285-74522307 (+)	28 bp
Tssr18410	Chr2:74522309-74522320 (+)	47 bp
Tssr18411	Chr2:74522395-74522418 (+)	139 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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