hpc Gene Detail

Summary

• Symbol
  hpc
• Name
  hyperspiny Purkinje cell

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:96212
  NCBI Gene: 15443
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  16 phenotypes from 1 allele in 2 genetic backgrounds
  5 phenotype references
  

• All Mutations and Alleles
  1
• Chemically induced (other)
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a chemically-induced allele are sterile and growth retarded, show a reduced cerebellar cortex, hyperspiny Purkinje cells, an atrophic dendritic tree and signs of axonal degeneration, and develop a fatal disease characterized by abnormal motor behavior and cerebellar symptoms.

Sequences &
Gene Models

• NCBI Gene
  15443

Other
Accession IDs

MGD-MRK-10913

References

• Summaries
  All 7

  Phenotypes 5
• Earliest
  J:7047 Guenet JL, et al., Hyperspiny Purkinje cell, a new neurological mutation in the mouse. J Hered. 1983 Mar-Apr;74(2):105-8
• Latest
  J:106373 Frederic F, et al., Cell Counts of Purkinje and Inferior Olivary Neurons in the 'Hyperspiny Purkinje Cells' Mutant Mouse. Eur J Neurosci. 1992;4(2):127-135