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Hr Gene Detail
Summary
  • Symbol
    Hr
  • Name
    lysine demethylase and nuclear receptor corepressor
  • Synonyms
    ba, bldy, N, rh, rh-bmh
  • Feature Type
    protein coding gene
  • IDs
    MGI:96223
    NCBI Gene: 15460
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70789652-70810988 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Mapping Data
    28 experiments
Strain
Comparison
more
  • SNPs within 2kb
    447 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96223
 protein coding gene Chr14:70789644-70810988 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021543
 protein coding gene Chr14:65209418-65231536 (+)
A/J MGP_AJ_G0021502
 protein coding gene Chr14:63822150-63842746 (+)
AKR/J MGP_AKRJ_G0021478
 protein coding gene Chr14:65734933-65755662 (+)
BALB/cJ MGP_BALBcJ_G0021508
 protein coding gene Chr14:63584529-63605273 (+)
C3H/HeJ MGP_C3HHeJ_G0021285
 protein coding gene Chr14:65450143-65470883 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021947
 protein coding gene Chr14:68121030-68141768 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019487
 protein coding gene Chr14:61658857-61679117 (+)
CAST/EiJ MGP_CASTEiJ_G0020802
 protein coding gene Chr14:62047839-62068364 (+)
CBA/J MGP_CBAJ_G0021252
 protein coding gene Chr14:70262549-70286138 (+)
DBA/2J MGP_DBA2J_G0021375
 protein coding gene Chr14:63205969-63227252 (+)
FVB/NJ MGP_FVBNJ_G0021354
 protein coding gene Chr14:62635748-62656575 (+)
LP/J MGP_LPJ_G0021446
 protein coding gene Chr14:66450598-66471194 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021383
 protein coding gene Chr14:69148399-69169212 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021971
 protein coding gene Chr14:64997336-65018001 (+)
PWK/PhJ MGP_PWKPhJ_G0020546
 protein coding gene Chr14:59973384-59996501 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020379
 protein coding gene Chr14:60926060-60946804 (+)
WSB/EiJ MGP_WSBEiJ_G0020855
 protein coding gene Chr14:65310015-65330716 (+)



Homology
more
  • Human Ortholog
    HR, HR lysine demethylase and nuclear receptor corepressor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HR, HR lysine demethylase and nuclear receptor corepressor
  • Synonyms
    ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1
  • Links
    NCBI Gene ID: 55806
    neXtProt AC: NX_O43593
    UniProt: O43593

  • Chr Location
    8p21.3; chr8:22114419-22133384 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Hr mouse models; 3 with human HR associations

Human Disease Mouse Models
      
IDs
 View 3 models
IDs
 View 2 models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    128 phenotypes from 29 alleles in 29 genetic backgrounds
    48 phenotypes from multigenic genotypes
    9 images
    190 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant homozygotes exhibit hair loss, usually wrinkled skin with epidermal cysts. Females do not nurse their pups well.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    110
  • cDNA Data
    40
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022096 Ensembl Gene Model | MGI Sequence Detail 21337 C57BL/6J ±  kb
    transcript ENSMUST00000163060 Ensembl | MGI Sequence Detail 5278 Not Applicable  
    polypeptide ENSMUSP00000124042 Ensembl | MGI Sequence Detail 1211 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      Genomic 10
      cDNA 40
      Primer pair 8
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10929, MGI:1890458, MGI:2661845
    References
    more
    • Summaries
      All 288
      Developmental Gene Expression 14
      Diseases 4
      Gene Ontology 8
      Phenotypes 190
    • Earliest
      J:2405 Brooke HC, Hairless mice. J Hered. 1926;17(5):173-74
    • Latest
      J:353825 Wang Q, et al., A pro-metastatic tRNA fragment drives aldolase A oligomerization to enhance aerobic glycolysis in lung adenocarcinoma. Cell Rep. 2024 Aug 27;43(8):114550
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory