About   Help   FAQ
Hsf1 Gene Detail
Summary
  • Symbol
    Hsf1
  • Name
    heat shock factor 1
  • Synonyms
    heat shock transcription factor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96238
    NCBI Gene: 15499
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76361562-76385355 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.95 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    487 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96238
 protein coding gene Chr15:76361562-76386113 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021994
 protein coding gene Chr15:76552171-76578960 (+)
A/J MGP_AJ_G0021952
 protein coding gene Chr15:73767016-73790430 (+)
AKR/J MGP_AKRJ_G0021935
 protein coding gene Chr15:75766429-75791447 (+)
BALB/cJ MGP_BALBcJ_G0021961
 protein coding gene Chr15:73794532-73818614 (+)
C3H/HeJ MGP_C3HHeJ_G0021733
 protein coding gene Chr15:75815084-75839453 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022401
 protein coding gene Chr15:79418895-79443126 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019930
 protein coding gene Chr15:70428074-70454083 (+)
CAST/EiJ MGP_CASTEiJ_G0021252
 protein coding gene Chr15:76617589-76642200 (+)
CBA/J MGP_CBAJ_G0021700
 protein coding gene Chr15:81922434-81953586 (+)
DBA/2J MGP_DBA2J_G0021825
 protein coding gene Chr15:73303646-73327004 (+)
FVB/NJ MGP_FVBNJ_G0021805
 protein coding gene Chr15:72359033-72383460 (+)
LP/J MGP_LPJ_G0021896
 protein coding gene Chr15:76654332-76677639 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021830
 protein coding gene Chr15:87257600-87284227 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022421
 protein coding gene Chr15:76019422-76044663 (+)
PWK/PhJ MGP_PWKPhJ_G0020993
 protein coding gene Chr15:73466622-73492856 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020833
 protein coding gene Chr15:75733513-75758713 (+)
WSB/EiJ MGP_WSBEiJ_G0021304
 protein coding gene Chr15:76121942-76150266 (+)



Homology
more
  • Human Ortholog
    HSF1, heat shock transcription factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSF1, heat shock transcription factor 1
  • Synonyms
    HSTF1
  • Links
    NCBI Gene ID: 3297
    neXtProt AC: NX_Q00613
    UniProt: Q00613

  • Chr Location
    8q24.3; chr8:144291591-144314720 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HSF1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 5 alleles in 8 genetic backgrounds
    27 phenotypes from multigenic genotypes
    4 images
    133 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this gene results in female infertility. Additional abnormalities observed in one line of targeted mice include placental defects, growth retardation, loss of the classical heat shock response, and impaired immune response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    129
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    874
  • Tissues
    117
  • cDNA Data
    60
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15499 NCBI Gene Model | MGI Sequence Detail 23794 C57BL/6J ±  kb
    transcript NM_001331152 RefSeq | MGI Sequence Detail 2434 ZRU/MplStud  
    polypeptide P38532 UniProt | EBI | MGI Sequence Detail 525 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      13 Sequences
    • Protein Ontology
      PR:000008790 heat shock factor protein 1
      (term hierarchy)
    • InterPro Domains
      IPR000232 Heat shock factor (HSF)-type, DNA-binding
      IPR027725 Heat shock transcription factor family
      IPR010542 Vertebrate heat shock transcription factor, C-terminal domain
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    • GlyGen
      P38532 3 sites, 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 76
      Genomic 6
      cDNA 64
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10952, MGI:2145933
    References
    more
    • Summaries
      All 231
      Developmental Gene Expression 16
      Diseases 2
      Gene Ontology 16
      Phenotypes 133
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:347775 Yoshimura S, et al., Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions. Nat Commun. 2024 Apr 29;15(1):3330
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory