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Hspb1 Gene Detail
Summary
  • Symbol
    Hspb1
  • Name
    heat shock protein 1
  • Synonyms
    Hsp25
  • Feature Type
    protein coding gene
  • IDs
    MGI:96240
    NCBI Gene: 15507
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135916773-135918417 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 75.51 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96240
 protein coding gene Chr5:135916773-135918417 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030192
 protein coding gene Chr5:140485834-140487595 (+)
A/J MGP_AJ_G0030160
 protein coding gene Chr5:134447226-134448870 (+)
AKR/J MGP_AKRJ_G0030093
 protein coding gene Chr5:138794890-138796548 (+)
BALB/cJ MGP_BALBcJ_G0030170
 protein coding gene Chr5:135798914-135800750 (+)
C3H/HeJ MGP_C3HHeJ_G0029886
 protein coding gene Chr5:139391087-139396805 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030623
 protein coding gene Chr5:145720353-145725123 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029296
 protein coding gene Chr5:138801603-138803261 (+)
CBA/J MGP_CBAJ_G0029856
 protein coding gene Chr5:151376446-151378090 (+)
DBA/2J MGP_DBA2J_G0030007
 protein coding gene Chr5:134340874-134343360 (+)
FVB/NJ MGP_FVBNJ_G0029962
 protein coding gene Chr5:133490904-133494364 (+)
LP/J MGP_LPJ_G0030096
 protein coding gene Chr5:140912223-140913976 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029994
 protein coding gene Chr5:154393527-154396140 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030663
 protein coding gene Chr5:138588804-138590448 (+)
PWK/PhJ MGP_PWKPhJ_G0019525
 protein coding gene Chr13:41939180-41940104 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028845
 protein coding gene Chr5:136137311-136138969 (+)
WSB/EiJ MGP_WSBEiJ_G0029369
 protein coding gene Chr5:139317766-139320920 (+)



Homology
more
  • Human Ortholog
    HSPB1, heat shock protein family B (small) member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPB1, heat shock protein family B (small) member 1
  • Synonyms
    CMT2F, HEL-S-102, HMN2B, HMND3, HS.76067, Hsp25, HSP27, HSP28, SRP27
  • Links
    NCBI Gene ID: 3315
    neXtProt AC: NX_P04792
    UniProt: P04792

  • Chr Location
    7q11.23; chr7:76302673-76304295 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human HSPB1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    3 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable and fertile with no apparent tissue abnormalities under physiological conditions. Mice homozygous for one knock-out allele exhibit impaired wound healing with delayed wound closing and abnormal inflammatory response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    863
  • Tissues
    108
  • cDNA Data
    302
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15507 NCBI Gene Model | MGI Sequence Detail 1645 C57BL/6J ±  kb
    transcript NM_013560 RefSeq | MGI Sequence Detail 913 ZRU/MplStud  
    polypeptide P14602 UniProt | EBI | MGI Sequence Detail 209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 317
      Genomic 6
      cDNA 302
      Primer pair 7
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-10954
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 32
      Gene Ontology 15
      Phenotypes 16
    • Earliest
      J:40710 Gaestel M, et al., Molecular cloning, sequencing and expression in Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins. Eur J Biochem. 1989 Jan 15;179(1):209-13
    • Latest
      J:347712 He J, et al., Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of Prdx1. Int J Biol Sci. 2024;20(5):1707-1728
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory