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Hspd1 Gene Detail
Summary
  • Symbol
    Hspd1
  • Name
    heat shock protein 1 (chaperonin)
  • Synonyms
    Hsp60
  • Feature Type
    protein coding gene
  • IDs
    MGI:96242
    NCBI Gene: 15510
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:55116994-55127402 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 28.01 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    267 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96242
 protein coding gene Chr1:55116992-55127402 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016030
 protein coding gene Chr1:54789070-54802128 (-)
A/J MGP_AJ_G0016013
 protein coding gene Chr1:52884452-52895912 (-)
AKR/J MGP_AKRJ_G0015969
 protein coding gene Chr1:54320167-54332923 (-)
BALB/cJ MGP_BALBcJ_G0015968
 protein coding gene Chr1:52937913-52949205 (-)
C3H/HeJ MGP_C3HHeJ_G0015800
 protein coding gene Chr1:54565009-54575464 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016421
 protein coding gene Chr1:57052193-57072671 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014143
 protein coding gene Chr1:48980613-48991308 (-)
CAST/EiJ MGP_CASTEiJ_G0015382
 protein coding gene Chr1:53840262-53855576 (-)
CBA/J MGP_CBAJ_G0015772
 protein coding gene Chr1:58663810-58682581 (-)
DBA/2J MGP_DBA2J_G0015873
 protein coding gene Chr1:52310473-52320923 (-)
FVB/NJ MGP_FVBNJ_G0015875
 protein coding gene Chr1:51659045-51669219 (-)
LP/J MGP_LPJ_G0015945
 protein coding gene Chr1:55616979-55628940 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015895
 protein coding gene Chr1:61777013-61788750 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016468
 protein coding gene Chr1:54270943-54281401 (-)
PWK/PhJ MGP_PWKPhJ_G0015168
 protein coding gene Chr1:51674153-51684145 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014949
 protein coding gene Chr1:53900355-53910622 (-)
WSB/EiJ MGP_WSBEiJ_G0015445
 protein coding gene Chr1:53963848-53970316 (-)



Homology
more
  • Human Ortholog
    HSPD1, heat shock protein family D (Hsp60) member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPD1, heat shock protein family D (Hsp60) member 1
  • Synonyms
    CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13
  • Links
    NCBI Gene ID: 3329
    neXtProt AC: NX_P10809
    UniProt: P10809

  • Chr Location
    2q33.1; chr2:197486584-197516737 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hspd1 mouse models; 7 with human HSPD1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 3 alleles in 5 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trap allele exhibit embryonic lethality between E7.5 and E9.75 associated with growth retardation. Males heterozygous for a gene-trap allele produce fewer female offspring than expected. Heterozygotes develop a slowly progressive motor defect resembling spastic paraplegia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    126
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    60
  • cDNA Data
    366
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025980 Ensembl Gene Model | MGI Sequence Detail 10409 C57BL/6J ±  kb
    transcript ENSMUST00000027123 Ensembl | MGI Sequence Detail 2423 Not Applicable  
    polypeptide ENSMUSP00000027123 Ensembl | MGI Sequence Detail 573 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008824 60 kDa heat shock protein, mitochondrial
      (term hierarchy)
    • EC
      5.6.1.7
    • InterPro Domains
      IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
      IPR018370 Chaperonin Cpn60, conserved site
      IPR001844 Chaperonin Cpn60/GroEL
      IPR002423 Chaperonin Cpn60/GroEL/TCP-1 family
      IPR027409 GroEL-like apical domain superfamily
      IPR027413 GroEL-like equatorial domain superfamily
      IPR027410 TCP-1-like chaperonin intermediate domain superfamily
    • GlyGen
      P63038 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 368
      cDNA 366
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10957
    References
    more
    • Summaries
      All 128
      Developmental Gene Expression 23
      Diseases 1
      Gene Ontology 34
      Phenotypes 23
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:353791 Xu L, et al., Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells. Cell Stem Cell. 2024 Aug 16;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory