Hspa2 MGI Mouse Gene Detail - MGI:96243

Symbol

Hspa2
Name

heat shock protein 2
Synonyms

70kDa, Hsp70-2

Feature Type

protein coding gene
IDs

MGI:96243
NCBI Gene: 15512
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr12:76450950-76453712 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 33.73 cM
Mapping Data

12 experiments

SNPs within 2kb

136 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96243	protein coding gene	Chr12:76450688-76453712 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019858	protein coding gene	Chr12:76515818-76518576 (+)
A/J	MGP_AJ_G0019816	protein coding gene	Chr12:73610768-73613526 (+)
AKR/J	MGP_AKRJ_G0019791	protein coding gene	Chr12:75837962-75840706 (+)
BALB/cJ	MGP_BALBcJ_G0019795	protein coding gene	Chr12:74084866-74087624 (+)
C3H/HeJ	MGP_C3HHeJ_G0019601	protein coding gene	Chr12:76297170-76299928 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020247	protein coding gene	Chr12:78861060-78863818 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017865	protein coding gene	Chr12:70941868-70944620 (+)
CAST/EiJ	MGP_CASTEiJ_G0019152	protein coding gene	Chr12:71108168-71110916 (+)
CBA/J	MGP_CBAJ_G0019571	protein coding gene	Chr12:81909409-81912167 (+)
DBA/2J	MGP_DBA2J_G0019687	protein coding gene	Chr12:73459663-73462407 (+)
FVB/NJ	MGP_FVBNJ_G0019674	protein coding gene	Chr12:72302656-72305407 (+)
LP/J	MGP_LPJ_G0019759	protein coding gene	Chr12:76491834-76494592 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019713	protein coding gene	Chr12:84934830-84937588 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020283	protein coding gene	Chr12:75311010-75313768 (+)
PWK/PhJ	MGP_PWKPhJ_G0018918	protein coding gene	Chr12:67831392-67834195 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018712	protein coding gene	Chr12:69830357-69833114 (+)
WSB/EiJ	MGP_WSBEiJ_G0019204	protein coding gene	Chr12:75931070-75933814 (+)

Human Ortholog

HSPA2, heat shock protein family A (Hsp70) member 2

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSPA2, heat shock protein family A (Hsp70) member 2
Synonyms

HSP70-2, HSP70-3
Links

HGNC:5235

NCBI Gene ID: 3306

neXtProt AC: NX_P54652

UniProt: P54652
Chr Location

14q23.3; chr14:64535905-64546173 (+) GRCh38

MGI Vertebrate Homology

Hspa2 stringent orthology
1 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: HSPA2
Gene Tree

Hspa2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Targeted

3
Genomic Mutations

1 involving Hspa2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygotes for a targeted null mutation exhibit male sterility associated with lack of postmeiotic germ cells and markedly increased frequency of spermatocyte apoptosis.

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All GO Annotations

59
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

813
Tissues

20
cDNA Data

35
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hspa2

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All Sequences

39
RefSeq

8
UniProt

1
CCDS

CCDS25993.1

Ensembl

ENSMUSG00000059970 (Evidence)
NCBI Gene

15512

			Length	Strain/Species	Flank
genomic	ENSMUSG00000059970	Ensembl Gene Model \| MGI Sequence Detail	2763	C57BL/6J	± kb
transcript	ENSMUST00000080449	Ensembl \| MGI Sequence Detail	2524	Not Applicable
polypeptide	ENSMUSP00000079306	Ensembl \| MGI Sequence Detail	633	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008807 heat shock-related 70 kDa protein 2

(term hierarchy)
InterPro Domains

IPR043129 ATPase, nucleotide binding domain

IPR018181 Heat shock protein 70, conserved site

IPR013126 Heat shock protein 70 family

IPR029048 Heat shock protein 70kD, C-terminal domain superfamily

IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
GlyGen

P17156 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 50

Genomic 12

cDNA 35

Primer pair 3

Microarray probesets 3

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MGD-MRK-10959, MGD-MRK-19433

Summaries

All 74

Developmental Gene Expression 10

Gene Ontology 22

Phenotypes 13
Earliest

J:9294 Zakeri ZF, et al., Identification and sequence analysis of a new member of the mouse HSP70 gene family and characterization of its unique cellular and developmental pattern of expression in the male germ line. Mol Cell Biol. 1988 Jul;8(7):2925-32
Latest

J:352963 Pfaltzgraff NG, et al., Destabilization of mRNAs enhances competence to initiate meiosis in mouse spermatogenic cells. Development. 2024 Jul 15;151(14)

TSS for Hspa2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113961	Chr12:76450685-76450696 (+)	-259 bp
Tssr113962	Chr12:76450942-76451038 (+)	40 bp
Tssr113963	Chr12:76451052-76451063 (+)	108 bp
Tssr113964	Chr12:76451159-76451170 (+)	215 bp
Tssr113965	Chr12:76451178-76451200 (+)	239 bp
Tssr113966	Chr12:76451253-76451256 (+)	305 bp
Tssr113967	Chr12:76451298-76451303 (+)	351 bp
Tssr113968	Chr12:76452326-76452337 (+)	1,382 bp
Tssr113969	Chr12:76452876-76452890 (+)	1,933 bp
Tssr113970	Chr12:76453222-76453231 (+)	2,277 bp
Tssr113971	Chr12:76453273-76453283 (+)	2,328 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24