Hspa1a MGI Mouse Gene Detail - MGI:96244

Symbol

Hspa1a
Name

heat shock protein 1A
Synonyms

Hsp68, Hsp70-3, Hsp70.3, Hsp70a1

Feature Type

protein coding gene
IDs

MGI:96244
NCBI Gene: 193740
Alliance

gene page
Transcription Start Sites

3 TSS
Candidate for QTL

1 QTL

Sequence Map

Chr17:35188335-35191132 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.51 cM
Mapping Data

12 experiments

Strain Annotations

14

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96244	protein coding gene	Chr17:35188166-35191132 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023601	protein coding gene	Chr17:35098529-35101886 (-)
A/J	no annotation
AKR/J	MGP_AKRJ_G0023530	protein coding gene	Chr17:34408224-34411190 (-)
BALB/cJ	MGP_BALBcJ_G0023567	protein coding gene	Chr17:34050970-34053086 (-)
C3H/HeJ	MGP_C3HHeJ_G0023328	protein coding gene	Chr17:34792063-34795609 (-)
C57BL/6NJ	no annotation
CAROLI/EiJ	MGP_CAROLIEiJ_G0021488	protein coding gene	Chr17:31712212-31715172 (-)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0023305	protein coding gene	Chr17:37926828-37929645 (-)
DBA/2J	MGP_DBA2J_G0023433	protein coding gene	Chr17:33259817-33263593 (-)
FVB/NJ	MGP_FVBNJ_G0023402	protein coding gene	Chr17:33096328-33099812 (-)
LP/J	MGP_LPJ_G0023512	protein coding gene	Chr17:35424690-35427414 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023423	protein coding gene	Chr17:36862322-36866079 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024050	protein coding gene	Chr17:34618077-34621942 (-)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0022392	protein coding gene	Chr17:32637599-32641054 (-)
WSB/EiJ	MGP_WSBEiJ_G0022887	protein coding gene	Chr17:34746310-34752877 (-)

Human Ortholog

HSPA1A, heat shock protein family A (Hsp70) member 1A

Vertebrate Orthologs

9

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSPA1A, heat shock protein family A (Hsp70) member 1A
Synonyms

HEL-S-103, HSP70, HSP70-1, HSP70.1, HSP70-1A, HSP70-2, HSP70.2, HSP70I, HSP72, HSPA1
Links

HGNC:5232

NCBI Gene ID: 3303

neXtProt AC: NX_P0DMV8, NX_P0DMV9

UniProt: P0DMV8
Chr Location

6p21.33; chr6:31815543-31817946 (+) GRCh38

Human Ortholog

HSPA1B, heat shock protein family A (Hsp70) member 1B
Synonyms

HSP70-1, HSP70.1, HSP70-1B, HSP70-2, HSP70.2, HSP72, HSPA1, HSX70
Links

HGNC:5233

NCBI Gene ID: 3304

neXtProt AC: NX_P0DMV8, NX_P0DMV9

UniProt: P0DMV9
Chr Location

6p21.33; chr6:31827738-31830254 (+) GRCh38

MGI Vertebrate Homology

Hspa1a stringent orthology
2 human;1 mouse;2 rat;5 zebrafish
HCOP

vertebrate homology predictions: HSPA1A, HSPA1B
Gene Tree

Hspa1a

Diseases

21 with human HSPA1A,HSPA1B associations

				Human Disease	Mouse Models
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395
				atherosclerosis IDs atherosclerosis DOID:1936 EFO:0003914 ICD10CM:I70 ICD9CM:440 MESH:D050197 NCI:C35768 UMLS_CUI:C0004153
				brain ischemia IDs brain ischemia DOID:2316 MESH:D002545 UMLS_CUI:C0007786
				CAKUT IDs CAKUT DOID:0080205 MESH:C566906 OMIM:PS610805 ORDO:93545
				cystic fibrosis IDs cystic fibrosis DOID:1485 DOID:12447 DOID:13383 DOID:14395 DOID:1484 ICD10CM:E84 ICD9CM:277.0 MESH:D003550 NCI:C2975 OMIM:219700 ORDO:586 UMLS_CUI:C0010674
				familial hyperlipidemia IDs familial hyperlipidemia DOID:1168 DOID:3147 ICD10CM:E78.5 MESH:D006949 MESH:D006951 NCI:C34707 NCI:C34709 UMLS_CUI:C0020473 UMLS_CUI:C0020476
				Kawasaki disease IDs Kawasaki disease DOID:13378 EFO:0004246 ICD10CM:M30.3 ICD9CM_2006:446.1 ICD9CM:446.1 MESH:D009080 NCI:C34825 OMIM:611775 UMLS_CUI:C0026691
				major depressive disorder IDs major depressive disorder DOID:1470 DOID:10614 DOID:2240 DOID:2241 DOID:7580 EFO:0003761 ICD10CM:F32 ICD10CM:F33.9 ICD9CM:296.2 ICD9CM:296.20 ICD9CM:296.3 ICD9CM:296.30 NCI:C34796 OMIM:608520 OMIM:608691 UMLS_CUI:C0024517 UMLS_CUI:C0154409
				Meniere's disease IDs Meniere's disease DOID:9849 ICD10CM:H81.0 ICD9CM:386.0 ICD9CM:386.00 MESH:D008575 NCI:C185243 OMIM:156000 UMLS_CUI:C0025281
				obesity IDs obesity DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C159658 OMIM:601665 UMLS_CUI:C0028754
				paranoid schizophrenia IDs paranoid schizophrenia DOID:1229 DOID:11238 DOID:1230 ICD10CM:F20.0 ICD9CM_2006:295.3 ICD9CM:295.3 ICD9CM:295.30 ICD9CM:295.31 ICD9CM:295.32 MESH:D012563 NCI:C35006 UMLS_CUI:C0036349 UMLS_CUI:C0270398
				Parkinsonism IDs Parkinsonism DOID:0080855
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341
				senile cataract IDs senile cataract DOID:9669 ICD10CM:H25 ICD9CM:366.1 ICD9CM:366.10 NCI:C35012 UMLS_CUI:C0036646
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141
				toxic shock syndrome IDs toxic shock syndrome DOID:14115 ICD10CM:A48.3 ICD9CM:040.82 MESH:D012772 NCI:C35498 UMLS_CUI:C0600327
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695
				urinary tract infection IDs urinary tract infection DOID:0080784 ICD10CM:N39.0 MESH:D014552
				vascular dementia IDs vascular dementia DOID:8725 DOID:13915 ICD10CM:F01 ICD9CM:290.4 MESH:D015140 MESH:D015161 NCI:C34522 NCI:C34525 UMLS_CUI:C0011263 UMLS_CUI:C0011269
				vitiligo IDs vitiligo DOID:12306 EFO:0004208 ICD10CM:L80 ICD9CM:709.01 MESH:D014820 NCI:C26915 OMIM:193200 UMLS_CUI:C0042900

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 2 alleles in 1 genetic background
50 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Genomic Mutations

1 involving Hspa1a
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

24 strains or lines available

At the cellular level, mice homozygous for a knock-out allele exhibit impaired thermotolerance and increased sensitivity to heat stress-induced apoptosis.

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All GO Annotations

102
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

766
Tissues

30
cDNA Data

40
Literature Summary

16

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hspa1a

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS50080.1

Ensembl

ENSMUSG00000091971 (Evidence)
NCBI Gene

193740

			Length	Strain/Species	Flank
genomic	193740	NCBI Gene Model \| MGI Sequence Detail	2798	C57BL/6J	± kb
transcript	NM_010479	RefSeq \| MGI Sequence Detail	2798	ZRU/MplStud
polypeptide	Q61696	UniProt \| EBI \| MGI Sequence Detail	641	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008871 heat shock 70 kDa protein 1A

(term hierarchy)
GlyGen

Q61696 1 site, 1 O-linked glycan (1 site)

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All nucleic 58

Genomic 16

cDNA 40

Primer pair 2

Microarray probesets 3

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MGD-MRK-10960

Summaries

All 134

Developmental Gene Expression 16

Gene Ontology 16

Phenotypes 50
Earliest

J:14783 Lowe DG, et al., Molecular cloning and analysis of DNA complementary to three mouse Mr = 68,000 heat shock protein mRNAs. J Biol Chem. 1986 Feb 15;261(5):2102-12
Latest

J:345820 Cardarelli S, et al., Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress. Cell Death Dis. 2024 Feb 23;15(2):169

TSS for Hspa1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147705	Chr17:35191126-35191134 (-)	2 bp
Tssr147704	Chr17:35188780-35188783 (-)	2,350 bp
Tssr147703	Chr17:35188394-35188403 (-)	2,733 bp

Hspa1a is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Cdcs5	Chr17, syntenic		J:109420	Microarray analysis was used to identify candidate genes for colitis susceptibility QTLs. Messenger RNA was analyzed for expression differences between colitis susceptible inbred strain C3H/HeJBir-Il10 and colitis resistant inbred strain C57BL/6J-Il10. Capn3 (67.2 cM) on mouse Chromosome 2 is upregulated 1.5- to 2-fold in C3H/HeJBir-Il10 animals. This candidate gene maps to the Cdcs3 (cytokine deficiency colitis susceptibility 3) interval centered near 65 cM. Gbp1 (67.4 cM) on mouse Chromosome 3 is upregulated over 15-fold in C3H/HeJBir-Il10 animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wild type strains. Gbp1 maps to the Cdcs1 (cytokine deficiency colitis susceptibility 1) interval centered near 62 cM. Adh1 at 71.2 cM and Bglap2 at 42.6 cM also map to the same QTL interval. Adh1 is upregulated 1.5- to 2-fold, and Blgap2 is upregulated 2- to 5-fold, in C3H/HeJBir-Il10animals. Pla2g2a (68 cM) on mouse Chromosome 4 is upregulated over 15-fold in C3H/HeJBir-Il10 animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wild typestrains. Pla2g2a maps to the Cdcs9 (cytokine deficiency colitis susceptibility 9) interval centered near 71 cM. Moreover, C57BL/6J animals are known to carry the frameshift mutation Pla2g2a resulting in multiple intestinal neoplasia. The human ortholog PLA2G2A maps near a irritable bowel disorder (IBD) susceptibility locus named IBD7. Gnb1 (79.4 cM) also maps to the Cdcs9 QTL interval and is upregulated 2- to 5-fold in C57BL/6J-Il10 animals. Errfi1 (formerly 1300002F13Rik) and Tceb3 also map to the Cdcs9 interval and are upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals. Areg (51 cM) on mouse Chromosome 5 maps near the Cdcs10 QTL interval centered around 45 cM. This candidate gene is upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals. Mtmr7 maps to mouse Chromosome 8 near the Cdcs4 interval centered around 21 cM. This candidate gene is upregulated over 15-fold in C57BL/6J-Il10 animals. Cd14 (31 cM) on mouse Chromosome 18 is upregulated 5- to 15-fold in C3H/HeJBir-Il10 animals. CD14 also exhibits expression differences in parental wild type strains C3H/HeJBir and C57BL/6J. This candidate gene maps to the Cdcs6 (cytokine deficiency colitis susceptibility 6) interval centered near 41 cM. The human ortholog CD14 maps near a human irritable bowel disorder (IBD) susceptibility locus named IBD5. Glo1 (16 cM) and Ly6g6c on mouse Chromosome 17 are upregulated 2- to 5-fold in C57BL/6J-Il10 animals. This candidate gene maps to the Cdcs5 (cytokine deficiency colitis susceptibility 5) interval centered near 19 cM. Hspa1a (18.9 cM) and Hspa1b (18.9 cM) also map to Cdcs5 and are upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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