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Hspa9 Gene Detail
Summary
  • Symbol
    Hspa9
  • Name
    heat shock protein 9
  • Synonyms
    C3H-specific antigen, CSA, GRP75, Hsc74, Hsp74, Hsp74a, Hspa9a, mortalin, mot-2, mthsp70, PBP74
  • Feature Type
    protein coding gene
  • IDs
    MGI:96245
    NCBI Gene: 15526
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:35070467-35087404 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 18.80 cM, cytoband C
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    474 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96245
 protein coding gene Chr18:35070467-35087410 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024255
 protein coding gene Chr18:33188205-33206281 (-)
A/J MGP_AJ_G0024221
 protein coding gene Chr18:32056802-32074146 (-)
AKR/J MGP_AKRJ_G0024189
 protein coding gene Chr18:32977586-32996584 (-)
BALB/cJ MGP_BALBcJ_G0024221
 protein coding gene Chr18:32112845-32129770 (-)
C3H/HeJ MGP_C3HHeJ_G0023988
 protein coding gene Chr18:32992930-33009874 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024663
 protein coding gene Chr18:34444840-34461824 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022103
 protein coding gene Chr18:32195590-32211868 (-)
CAST/EiJ MGP_CASTEiJ_G0023463
 protein coding gene Chr18:32960855-32977763 (-)
CBA/J MGP_CBAJ_G0023956
 protein coding gene Chr18:35403308-35422471 (-)
DBA/2J MGP_DBA2J_G0024088
 protein coding gene Chr18:31710456-31727626 (-)
FVB/NJ MGP_FVBNJ_G0024055
 protein coding gene Chr18:31396242-31413171 (-)
LP/J MGP_LPJ_G0024170
 protein coding gene Chr18:33269719-33286617 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024083
 protein coding gene Chr18:36646725-36664369 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024711
 protein coding gene Chr18:32804741-32821656 (-)
PWK/PhJ MGP_PWKPhJ_G0023207
 protein coding gene Chr18:31920430-31938234 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023015
 protein coding gene Chr18:33072243-33089091 (-)
WSB/EiJ MGP_WSBEiJ_G0023526
 protein coding gene Chr18:32730786-32750426 (-)



Homology
more
  • Human Ortholog
    HSPA9, heat shock protein family A (Hsp70) member 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPA9, heat shock protein family A (Hsp70) member 9
  • Synonyms
    CRP40, CSA, EVPLS, GRP-75, GRP75, HEL-S-124m, HSPA9B, MOT, MOT2, MTHSP75, PBP74, SAAN, SIDBA4
  • Links
    NCBI Gene ID: 3313
    neXtProt AC: NX_P38646
    UniProt: P38646

  • Chr Location
    5q31.2; chr5:138553756-138575675 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human HSPA9 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality while heterozygotes display decreased pre-B cell number.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    21
  • cDNA Data
    361
  • Literature Summary
    9
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15526 NCBI Gene Model | MGI Sequence Detail 16938 C57BL/6J ±  kb
transcript NM_010481 RefSeq | MGI Sequence Detail 3067 ZRU/MplStud  
polypeptide P38647 UniProt | EBI | MGI Sequence Detail 679 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008813 stress-70 protein, mitochondrial
    (term hierarchy)
  • InterPro Domains
    IPR043129 ATPase, nucleotide binding domain
    IPR012725 Chaperone DnaK
    IPR018181 Heat shock protein 70, conserved site
    IPR013126 Heat shock protein 70 family
    IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
    IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
  • GlyGen
    P38647 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 375
    Genomic 8
    cDNA 363
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10961, MGI:1345461
References
more
  • Summaries
    All 89
    Developmental Gene Expression 9
    Gene Ontology 21
    Phenotypes 15
  • Earliest
    J:116661 Kusakabe M, et al., A novel methodology for analysis of cell distribution in chimeric mouse organs using a strain specific antibody. J Cell Biol. 1988 Jul;107(1):257-65
  • Latest
    J:352087 Zhao F, et al., GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development. Dev Cell. 2024 Jul 3;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory