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Hspg2 Gene Detail
Summary
  • Symbol
    Hspg2
  • Name
    perlecan (heparan sulfate proteoglycan 2)
  • Synonyms
    Pcn, per, perlecan, Plc
  • Feature Type
    protein coding gene
  • IDs
    MGI:96257
    NCBI Gene: 15530
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:137196080-137297941 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 69.93 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3054 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96257
 protein coding gene Chr4:137196062-137297941 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028983
 protein coding gene Chr4:140102454-140216974 (+)
A/J MGP_AJ_G0028942
 protein coding gene Chr4:134146192-134253516 (+)
AKR/J MGP_AKRJ_G0028894
 protein coding gene Chr4:138003541-138103964 (+)
BALB/cJ MGP_BALBcJ_G0028966
 protein coding gene Chr4:134829409-134930799 (+)
C3H/HeJ MGP_C3HHeJ_G0028680
 protein coding gene Chr4:138333045-138442425 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029407
 protein coding gene Chr4:145106535-145219771 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026678
 protein coding gene Chr4:127157617-127259958 (+)
CAST/EiJ MGP_CASTEiJ_G0028112
 protein coding gene Chr4:136469326-136580256 (+)
CBA/J MGP_CBAJ_G0028645
 protein coding gene Chr4:149181134-149302725 (+)
DBA/2J MGP_DBA2J_G0028794
 protein coding gene Chr4:134539752-134642973 (+)
FVB/NJ MGP_FVBNJ_G0028761
 protein coding gene Chr4:133534791-133641219 (+)
LP/J MGP_LPJ_G0028893
 protein coding gene Chr4:140200236-140309029 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028787
 protein coding gene Chr4:153232061-153342288 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029445
 protein coding gene Chr4:138477388-138583225 (+)
PWK/PhJ MGP_PWKPhJ_G0027832
 protein coding gene Chr4:131361620-131465442 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027658
 protein coding gene Chr4:134255414-134362985 (+)
WSB/EiJ MGP_WSBEiJ_G0028190
 protein coding gene Chr4:138675199-138785565 (+)



Homology
more
  • Human Ortholog
    HSPG2, heparan sulfate proteoglycan 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPG2, heparan sulfate proteoglycan 2
  • Synonyms
    HSPG, PLC, PRCAN, SJA, SJS, SJS1
  • Links
    NCBI Gene ID: 3339
    neXtProt AC: NX_P98160
    UniProt: P98160

  • Chr Location
    1p36.12; chr1:21822244-21937310 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with Hspg2 mouse models; 3 with human HSPG2 associations

Human Disease Mouse Models
      
IDs
 View 6 models
IDs
 View 2 models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    130 phenotypes from 7 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    6 images
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted null mutants die either at embryonic day 10.5 with cardiac outflow defects and/or brain exencephaly or at birth with skeletal dysplasia including micromelia and craniofacial defects. An exon 3 deletion mutant shows only a lens defect.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1154
  • Tissues
    316
  • cDNA Data
    117
  • Literature Summary
    131
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028763 Ensembl Gene Model | MGI Sequence Detail 101862 C57BL/6J ±  kb
    transcript ENSMUST00000171332 Ensembl | MGI Sequence Detail 14176 Not Applicable  
    polypeptide ENSMUSP00000131316 Ensembl | MGI Sequence Detail 4383 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 133
      cDNA 119
      Primer pair 10
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10976, MGD-MRK-13349, MGI:2140391
    References
    more
    • Summaries
      All 239
      Developmental Gene Expression 131
      Diseases 8
      Gene Ontology 25
      Phenotypes 56
    • Earliest
      J:23350 Ledbetter SR, et al., Identification of the precursor protein to basement membrane heparan sulfate proteoglycans. J Biol Chem. 1985 Jul 5;260(13):8106-113
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory