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Iapp Gene Detail
Summary
  • Symbol
    Iapp
  • Name
    islet amyloid polypeptide
  • Synonyms
    amylin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96382
    NCBI Gene: 15874
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:142244151-142249546 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 73.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    273 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96382
 protein coding gene Chr6:142244149-142249687 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031460
 protein coding gene Chr6:147085543-147091081 (+)
A/J MGP_AJ_G0031435
 protein coding gene Chr6:141304932-141310470 (+)
AKR/J MGP_AKRJ_G0031363
 protein coding gene Chr6:145502369-145507911 (+)
BALB/cJ MGP_BALBcJ_G0031442
 protein coding gene Chr6:141082870-141088408 (+)
C3H/HeJ MGP_C3HHeJ_G0031164
 protein coding gene Chr6:145551514-145557052 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031904
 protein coding gene Chr6:151124567-151130105 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029028
 protein coding gene Chr6:140152323-140155735 (+)
CAST/EiJ MGP_CASTEiJ_G0030532
 protein coding gene Chr6:145116369-145121857 (+)
CBA/J MGP_CBAJ_G0031124
 protein coding gene Chr6:156854884-156860422 (+)
DBA/2J MGP_DBA2J_G0031281
 protein coding gene Chr6:140116124-140121662 (+)
FVB/NJ MGP_FVBNJ_G0031232
 protein coding gene Chr6:138886008-138891531 (+)
LP/J MGP_LPJ_G0031365
 protein coding gene Chr6:147226230-147231744 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031272
 protein coding gene Chr6:160761474-160766995 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031936
 protein coding gene Chr6:145329847-145335385 (+)
PWK/PhJ MGP_PWKPhJ_G0030259
 protein coding gene Chr6:138615009-138620546 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030083
 protein coding gene Chr6:143525735-143531254 (+)
WSB/EiJ MGP_WSBEiJ_G0030625
 protein coding gene Chr6:145964942-145970461 (+)



Homology
more
  • Human Ortholog
    IAPP, islet amyloid polypeptide
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IAPP, islet amyloid polypeptide
  • Synonyms
    DAP, IAP
  • Links
    NCBI Gene ID: 3375
    neXtProt AC: NX_P10997
    UniProt: P10997

  • Chr Location
    12p12.1; chr12:21354959-21379980 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Iapp mouse models; 2 with human IAPP associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus increases glucose tolerance in a gender-dependent manner and results in decreased bone density due to increased bone resorption.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    12
  • cDNA Data
    10
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15874 NCBI Gene Model | MGI Sequence Detail 5396 C57BL/6J ±  kb
    transcript NM_010491 RefSeq | MGI Sequence Detail 725 ZRU/MplStud  
    polypeptide P12968 UniProt | EBI | MGI Sequence Detail 93 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 11
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11135
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 21
      Diseases 1
      Gene Ontology 8
      Phenotypes 37
    • Earliest
      J:9937 Nishi M, et al., Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5738-42
    • Latest
      J:353482 Ortiz JA, et al., Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for beta-Cell Function During Aging. Diabetes. 2024 Sep 1;73(9):1447-1461
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory