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Icam2 Gene Detail
Summary
  • Symbol
    Icam2
  • Name
    intercellular adhesion molecule 2
  • Synonyms
    CD102, Icam-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96394
    NCBI Gene: 15896
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106268482-106278901 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 69.09 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    358 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96394
 protein coding gene Chr11:106268482-106278948 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019307
 protein coding gene Chr11:109667142-109679084 (-)
A/J MGP_AJ_G0019275
 protein coding gene Chr11:105000779-105011889 (-)
AKR/J MGP_AKRJ_G0019244
 protein coding gene Chr11:108132761-108143524 (-)
BALB/cJ MGP_BALBcJ_G0019249
 protein coding gene Chr11:105409683-105420017 (-)
C3H/HeJ MGP_C3HHeJ_G0019058
 protein coding gene Chr11:108418824-108431162 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019699
 protein coding gene Chr11:113023197-113035130 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017323
 protein coding gene Chr11:102278517-102288819 (-)
CAST/EiJ MGP_CASTEiJ_G0018611
 protein coding gene Chr11:109485311-109497257 (-)
CBA/J MGP_CBAJ_G0019027
 protein coding gene Chr11:117733690-117743806 (-)
DBA/2J MGP_DBA2J_G0019139
 protein coding gene Chr11:104470708-104481107 (-)
FVB/NJ MGP_FVBNJ_G0019130
 protein coding gene Chr11:103977088-103987594 (-)
LP/J MGP_LPJ_G0019209
 protein coding gene Chr11:110112151-110122553 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019160
 protein coding gene Chr11:117001785-117012826 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019736
 protein coding gene Chr11:108621442-108632404 (-)
PWK/PhJ MGP_PWKPhJ_G0018376
 protein coding gene Chr11:105568173-105578629 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018167
 protein coding gene Chr11:108397564-108409330 (-)
WSB/EiJ MGP_WSBEiJ_G0018662
 protein coding gene Chr11:108590189-108600587 (-)



Homology
more
  • Human Ortholog
    ICAM2, intercellular adhesion molecule 2
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ICAM2, intercellular adhesion molecule 2
  • Synonyms
    CD102
  • Links
    NCBI Gene ID: 3384
    neXtProt AC: NX_P13598
    UniProt: P13598

  • Chr Location
    17q23.3; chr17:64002594-64020634 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in increased respiratory responsiveness due to an increased accumulation of eosinophils in the lung interstitium and a concomittant delay in the increase of eosinophils in the airway lumen during the development of an allergic inflammatory response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    37
  • cDNA Data
    29
  • Literature Summary
    25
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001029 Ensembl Gene Model | MGI Sequence Detail 10420 C57BL/6J ±  kb
transcript ENSMUST00000001055 Ensembl | MGI Sequence Detail 1282 Not Applicable  
polypeptide ENSMUSP00000001055 Ensembl | MGI Sequence Detail 277 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001358 intercellular adhesion molecule 2
    (term hierarchy)
  • PDB
    1J19
  • InterPro Domains
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003988 Intercellular adhesion molecule
    IPR013768 Intercellular adhesion molecule, N-terminal
    IPR047012 Intercellular adhesion molecule/vascular cell adhesion molecule
    IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
  • GlyGen
    P35330 5 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 37
    Genomic 6
    cDNA 29
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11147, MGD-MRK-11150
References
more
  • Summaries
    All 87
    Developmental Gene Expression 25
    Gene Ontology 10
    Phenotypes 26
  • Earliest
    J:2867 Xu H, et al., Isolation, characterization, and expression of mouse ICAM-2 complementary and genomic DNA. J Immunol. 1992 Oct 15;149(8):2650-5
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory