Id1 MGI Mouse Gene Detail - MGI:96396 - inhibitor of DNA binding 1, HLH protein

Symbol

Id1
Name

inhibitor of DNA binding 1, HLH protein
Synonyms

bHLHb24, D2Wsu140e, Idb1

Feature Type

protein coding gene
IDs

MGI:96396
NCBI Gene: 15901
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:152578171-152579330 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 75.41 cM
Mapping Data

4 experiments

SNPs within 2kb

58 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96396	protein coding gene	Chr2:152578171-152579330 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026676	protein coding gene	Chr2:157311929-157313087 (+)
A/J	MGP_AJ_G0026642	protein coding gene	Chr2:151029790-151030949 (+)
AKR/J	MGP_AKRJ_G0026612	protein coding gene	Chr2:155434208-155435367 (+)
BALB/cJ	MGP_BALBcJ_G0026651	protein coding gene	Chr2:151340509-151341667 (+)
C3H/HeJ	MGP_C3HHeJ_G0026394	protein coding gene	Chr2:155818591-155819749 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027100	protein coding gene	Chr2:161875017-161876176 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024471	protein coding gene	Chr2:144620068-144621219 (+)
CAST/EiJ	MGP_CASTEiJ_G0025855	protein coding gene	Chr2:156069639-156070797 (+)
CBA/J	MGP_CBAJ_G0026372	protein coding gene	Chr2:167837044-167838202 (+)
DBA/2J	MGP_DBA2J_G0026508	protein coding gene	Chr2:150243843-150245001 (+)
FVB/NJ	MGP_FVBNJ_G0026474	protein coding gene	Chr2:148701051-148702209 (+)
LP/J	MGP_LPJ_G0026612	protein coding gene	Chr2:157465549-157466707 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026495	protein coding gene	Chr2:171919740-171920899 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027156	protein coding gene	Chr2:155332145-155333303 (+)
PWK/PhJ	MGP_PWKPhJ_G0025589	protein coding gene	Chr2:149764373-149765531 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025392	protein coding gene	Chr2:154173131-154174277 (+)
WSB/EiJ	MGP_WSBEiJ_G0025925	protein coding gene	Chr2:156240843-156242001 (+)

Human Ortholog

ID1, inhibitor of DNA binding 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ID1, inhibitor of DNA binding 1
Synonyms

bHLHb24, ID
Links

HGNC:5360

NCBI Gene ID: 3397

neXtProt AC: NX_P41134

UniProt: P41134
Chr Location

20q11.21; chr20:31605283-31606515 (+) GRCh38

MGI Vertebrate Homology

Id1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ID1
Gene Tree

Id1

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

43 phenotypes from 3 alleles in 6 genetic backgrounds
43 phenotypes from multigenic genotypes
3 images
70 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

50
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

35
Radiation induced

1
Targeted

8
Transgenic

1
Genomic Mutations

2 involving Id1
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for knockout alleles of both Id1 and Id3 exhibit vascular malformations in the forebrain, lack of vascular branching and sprouting in the neuroectoderm, and impaired angiogenesis in transplanted and spontaneous tumors.

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All GO Annotations

57
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1545
Tissues

545
cDNA Data

107
Literature Summary

143

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ID1

ZFIN id1

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All Sequences

45
RefSeq

6
UniProt

3
CCDS

CCDS16897.1, CCDS89567.1

Ensembl

ENSMUSG00000042745 (Evidence)
NCBI Gene

15901

			Length	Strain/Species	Flank
genomic	15901	NCBI Gene Model \| MGI Sequence Detail	1160	C57BL/6J	± kb
transcript	NM_001369018	RefSeq \| MGI Sequence Detail	1160	ZRU/MplStud
polypeptide	P20067	UniProt \| EBI \| MGI Sequence Detail	168	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000000039 DNA-binding protein inhibitor ID-1

(term hierarchy)
PDB

6MGM, 6MGN, 6U2U
InterPro Domains

IPR026052 DNA-binding protein inhibitor

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

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All nucleic 128

cDNA 109

Primer pair 15

Other 4

Microarray probesets 3

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MGD-MRK-11153, MGD-MRK-35816, MGI:107350, MGI:2138900

Summaries

All 302

Developmental Gene Expression 143

Diseases 1

Gene Ontology 19

Phenotypes 70
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:358022 Littlejohn R, et al., Inhibition of cardiomyocyte neddylation impairs embryonic cardiac morphogenesis. J Mol Cell Cardiol. 2024 Oct 20;197:40-44

TSS for Id1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20826	Chr2:152578164-152578181 (+)	2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24