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Ido1 Gene Detail
Summary
  • Symbol
    Ido1
  • Name
    indoleamine 2,3-dioxygenase 1
  • Synonyms
    Ido, Indo
  • Feature Type
    protein coding gene
  • IDs
    MGI:96416
    NCBI Gene: 15930
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:25074148-25086987 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 12.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    474 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96416
 protein coding gene Chr8:25074148-25087025 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033471
 protein coding gene Chr8:22580543-22593317 (-)
A/J MGP_AJ_G0033451
 protein coding gene Chr8:21795220-21808490 (-)
AKR/J MGP_AKRJ_G0033376
 protein coding gene Chr8:22510964-22523682 (-)
BALB/cJ MGP_BALBcJ_G0033447
 protein coding gene Chr8:21927735-21940752 (-)
C3H/HeJ MGP_C3HHeJ_G0033161
 protein coding gene Chr8:22701704-22714500 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033963
 protein coding gene Chr8:23482905-23495758 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030913
 protein coding gene Chr8:19106107-19118782 (-)
CAST/EiJ MGP_CASTEiJ_G0032487
 protein coding gene Chr8:22122506-22136707 (-)
CBA/J MGP_CBAJ_G0033136
 protein coding gene Chr8:24416684-24429476 (-)
DBA/2J MGP_DBA2J_G0033291
 protein coding gene Chr8:21763839-21776639 (-)
FVB/NJ MGP_FVBNJ_G0033235
 protein coding gene Chr8:21554311-21567234 (-)
LP/J MGP_LPJ_G0033380
 protein coding gene Chr8:22577597-22590491 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033278
 protein coding gene Chr8:23942914-23956515 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033982
 protein coding gene Chr8:22434523-22450046 (-)
PWK/PhJ MGP_PWKPhJ_G0032198
 protein coding gene Chr8:21370416-21384020 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032032
 protein coding gene Chr8:21797116-21809653 (-)
WSB/EiJ MGP_WSBEiJ_G0032603
 protein coding gene Chr8:22649855-22662657 (-)



Homology
more
  • Human Ortholog
    IDO1, indoleamine 2,3-dioxygenase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IDO1, indoleamine 2,3-dioxygenase 1
  • Synonyms
    IDO, IDO-1, INDO
  • Links
    NCBI Gene ID: 3620
    neXtProt AC: NX_P14902
    UniProt: P14902

  • Chr Location
    8p11.21; chr8:39902275-39928790 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ido1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 2 alleles in 7 genetic backgrounds
    148 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele fail to induce IFN-alpha production by dendritic cells after B7 ligation, and show epididymal inflammation, teratospermia, and elevated caudal epididymal sperm counts along with higher protein and cytokine levels and reduced leukocyte count and proteasome activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    842
  • Tissues
    107
  • cDNA Data
    9
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15930 NCBI Gene Model | MGI Sequence Detail 12840 C57BL/6J ±  kb
    transcript NM_001293690 RefSeq | MGI Sequence Detail 1660 C57BL/6  
    polypeptide P28776 UniProt | EBI | MGI Sequence Detail 407 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11186
    References
    more
    • Summaries
      All 219
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 20
      Phenotypes 148
    • Earliest
      J:72138 Takikawa O, et al., Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase. J Biol Chem. 1986 Mar 15;261(8):3648-53
    • Latest
      J:350278 Johnson EE, et al., Retention of stress susceptibility in the mdx mouse model of Duchenne muscular dystrophy after PGC-1alpha overexpression or ablation of IDO1 or CD38. Hum Mol Genet. 2024 Mar 20;33(7):594-611
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory