Igf1 Gene Detail

Summary

• Symbol
  Igf1
• Name
  insulin-like growth factor 1
• Synonyms
  C730016P09Rik, Igf-1, Igf-I

• Feature Type
  protein coding gene
• IDs
  MGI:96432
  NCBI Gene: 16000
• Alliance
  gene page
• Transcription Start Sites
  103 TSS
• Candidate for QTL
  3 QTL

Location &
Maps

• Sequence Map
  Chr10:87694127-87772904 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 10, 43.70 cM
• Mapping Data
  32 experiments

Strain
Comparison

• SNPs within 2kb
  1629 from dbSNP Build 142
• Strain Annotations
  18
• PCR
  2
• RFLP
  2

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96432	protein coding gene	Chr10:87694127-87772909 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017620	protein coding gene	Chr10:88910317-88989161 (+)
A/J	MGP_AJ_G0017599	protein coding gene	Chr10:85928323-86007016 (+)
AKR/J	MGP_AKRJ_G0017557	protein coding gene	Chr10:88363860-88442515 (+)
BALB/cJ	MGP_BALBcJ_G0017562	protein coding gene	Chr10:86203116-86281833 (+)
C3H/HeJ	MGP_C3HHeJ_G0017385	protein coding gene	Chr10:88346682-88426699 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018019	protein coding gene	Chr10:91907890-91987972 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015701	protein coding gene	Chr10:81705352-81783964 (+)
CAST/EiJ	MGP_CASTEiJ_G0016950	protein coding gene	Chr10:88246857-88329281 (+)
CBA/J	MGP_CBAJ_G0017354	protein coding gene	Chr10:95718117-95796840 (+)
DBA/2J	MGP_DBA2J_G0017460	protein coding gene	Chr10:85050335-85130353 (+)
FVB/NJ	MGP_FVBNJ_G0017452	protein coding gene	Chr10:84276597-84355234 (+)
LP/J	MGP_LPJ_G0017534	protein coding gene	Chr10:89599478-89680011 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017483	protein coding gene	Chr10:97218491-97299946 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018056	protein coding gene	Chr10:88198188-88278226 (+)
PWK/PhJ	MGP_PWKPhJ_G0016731	protein coding gene	Chr10:85052342-85131506 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016519	protein coding gene	Chr10:86934044-87006220 (+)
WSB/EiJ	MGP_WSBEiJ_G0017009	protein coding gene	Chr10:88166201-88244890 (+)

Homology

• Human Ortholog
  IGF1, insulin like growth factor 1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  IGF1, insulin like growth factor 1
  
• Synonyms
  IGF, IGF-I, IGFI, MGF
• Links
  HGNC:5464

  NCBI Gene ID: 3479

  neXtProt AC: NX_P05019

  UniProt: P05019

  
  
• Chr Location
  12q23.2; chr12:102395874-102481839 (-)  GRCh38

---

• MGI Vertebrate Homology
  Igf1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: IGF1
• Gene Tree
  Igf1
  

Human Diseases

• Diseases
  12 with human IGF1 associations

				Human Disease	Mouse Models
				acne IDs acne       DOID:6543 DOID:9906 ICD10CM:L70 ICD10CM:L70.2 ICD9CM_2006:706.0 ICD9CM:706.0 MESH:D000152 OMIM:604324 UMLS_CUI:C0152249 UMLS_CUI:C0702166
				Alzheimer's disease IDs Alzheimer's disease       DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395
				brain ischemia IDs brain ischemia       DOID:2316 MESH:D002545 UMLS_CUI:C0007786
				diabetic retinopathy IDs diabetic retinopathy       DOID:8947 ICD9CM:362.0 MESH:D003930 NCI:C34538 UMLS_CUI:C0011884
				dilated cardiomyopathy IDs dilated cardiomyopathy       DOID:12930 EFO:0000407 ICD10CM:I42.0 KEGG:05414 MESH:D002311 NCI:C84673 OMIM:PS115200 ORDO:217604 UMLS_CUI:C0007193
				Huntington's disease IDs Huntington's disease       DOID:12858 ICD10CM:G10 ICD9CM_2006:333.4 ICD9CM:333.4 KEGG:05016 MESH:D006816 NCI:C82342 OMIM:143100 UMLS_CUI:C0020179
				microcephaly IDs microcephaly       DOID:10907 ICD10CM:Q02 ICD9CM_2006:742.1 ICD9CM:742.1 MESH:D008831 NCI:C85874 UMLS_CUI:C0025958
				myocardial infarction IDs myocardial infarction       DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				myopia IDs myopia       DOID:11830 ICD10CM:H52.1 ICD9CM:367.1 MESH:D009216 NCI:C102533 OMIM:160700 OMIM:255500 OMIM:300613 OMIM:310460 OMIM:603221 OMIM:608367 OMIM:608474 OMIM:608908 OMIM:609256 OMIM:609257 OMIM:609258 OMIM:609259 OMIM:609994 OMIM:609995 OMIM:610320 OMIM:612554 OMIM:612717 OMIM:613959 OMIM:613969 OMIM:614166 OMIM:614167 OMIM:615420 OMIM:615431 OMIM:615946 UMLS_CUI:C0027092
				pancreatic cancer IDs pancreatic cancer       DOID:1793 DOID:14356 DOID:1797 DOID:3588 DOID:9859 ICD10CM:C25.0 ICD10CM:C25.1 ICD10CM:C25.2 ICD9CM:157.0 ICD9CM:157.1 ICD9CM:157.2 ICD9CM:157.8 KEGG:05212 MESH:D010190 NCI:C3305 ORDO:1333 ORDO:217074 UMLS_CUI:C0030297 UMLS_CUI:C0153458 UMLS_CUI:C0153459 UMLS_CUI:C0153460 UMLS_CUI:C0153463
				type 1 diabetes mellitus IDs type 1 diabetes mellitus       DOID:9744 ICD10CM:E10 KEGG:04940 MESH:D003922 NCI:C2986 OMIM:222100 UMLS_CUI:C0011854
				type 2 diabetes mellitus IDs type 2 diabetes mellitus       DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  85 phenotypes from 9 alleles in 12 genetic backgrounds
  78 phenotypes from multigenic genotypes
  1 images
  214 phenotype references
  

• All Mutations and Alleles
  37
• Chemically induced (other)
  1
• Endonuclease-mediated
  9
• Gene trapped
  10
• Targeted
  15
• Transgenic
  2
• Genomic Mutations
  1 involving Igf1
• Find Mice (IMSR)
  29 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygous null mutants are severely growth retarded and die perinatally with many immature organ systems. Heterozygotes and partial knockouts show genetic background effects and can display growth retardation and abnormalities in muscle, lungs, and CNS.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  202
• GO References
  51

Expression

• Assay Results
  1154
• Tissues
  311
• cDNA Data
  32
• Literature Summary
  159

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GENSAT
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA IGF1
  ZFIN igf1

Sequences &
Gene Models

• All Sequences
  101
• RefSeq
  40
• UniProt
  8
• CCDS
  CCDS24103.1, CCDS24104.2, CCDS48661.1, CCDS48662.1, CCDS48663.1

• Ensembl
  ENSMUSG00000020053 (Evidence)
• NCBI Gene
  16000

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000020053	Ensembl Gene Model | MGI Sequence Detail	78778	C57BL/6J
transcript	ENSMUST00000062862	Ensembl | MGI Sequence Detail	2292	Not Applicable
polypeptide	ENSMUSP00000056668	Ensembl | MGI Sequence Detail	165	Not Applicable

Protein
Information

• UniProt
  8 Sequences
• Protein Ontology
  PR:000009182 insulin-like growth factor I
  (term hierarchy)
• InterPro Domains
  IPR022353 Insulin, conserved site
  IPR022352 Insulin family
  IPR016179 Insulin-like
  IPR022350 Insulin-like growth factor
  IPR022341 Insulin-like growth factor I
  IPR036438 Insulin-like superfamily

Molecular
Reagents

• All nucleic 68

  Genomic 3

  cDNA 35

  Primer pair 28

  Other 2

  
  

  Microarray probesets 6

Other
Accession IDs

MGD-MRK-11226, MGD-MRK-11228, MGI:2444166

References

• Summaries
  All 769

  Developmental Gene Expression 159

  Gene Ontology 51

  Phenotypes 214
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:357463 Flaherty SE 3rd, et al., SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction. Elife. 2024 Jul 26;12

TSS for Igf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95035	Chr10:87694117-87694156 (+)	10 bp
Tssr95036	Chr10:87694464-87694482 (+)	346 bp
Tssr95037	Chr10:87694501-87694511 (+)	379 bp
Tssr95038	Chr10:87694518-87694527 (+)	396 bp
Tssr95039	Chr10:87694543-87694557 (+)	423 bp
Tssr95040	Chr10:87694678-87694694 (+)	559 bp
Tssr95041	Chr10:87694908-87694919 (+)	787 bp
Tssr95042	Chr10:87694924-87694956 (+)	813 bp
Tssr95043	Chr10:87694969-87694988 (+)	852 bp
Tssr95044	Chr10:87695020-87695040 (+)	903 bp
Tssr95045	Chr10:87695042-87695057 (+)	923 bp
Tssr95046	Chr10:87695061-87695078 (+)	943 bp
Tssr95047	Chr10:87695095-87695106 (+)	974 bp
Tssr95048	Chr10:87695117-87695128 (+)	996 bp
Tssr95049	Chr10:87695141-87695150 (+)	1,019 bp
Tssr95050	Chr10:87695153-87695164 (+)	1,032 bp
Tssr95051	Chr10:87695172-87695196 (+)	1,057 bp
Tssr95052	Chr10:87695197-87695198 (+)	1,071 bp
Tssr95053	Chr10:87695218-87695229 (+)	1,097 bp
Tssr95054	Chr10:87695234-87695249 (+)	1,115 bp
Tssr95055	Chr10:87695343-87695354 (+)	1,222 bp
Tssr95056	Chr10:87695397-87695434 (+)	1,289 bp
Tssr95057	Chr10:87695455-87695474 (+)	1,338 bp
Tssr95058	Chr10:87695498-87695509 (+)	1,377 bp
Tssr95059	Chr10:87695560-87695569 (+)	1,438 bp
Tssr95060	Chr10:87695924-87695948 (+)	1,809 bp
Tssr95061	Chr10:87696006-87696021 (+)	1,887 bp
Tssr95062	Chr10:87696028-87696041 (+)	1,908 bp
Tssr95063	Chr10:87696083-87696102 (+)	1,966 bp
Tssr95064	Chr10:87696111-87696129 (+)	1,993 bp
Tssr95065	Chr10:87696299-87696326 (+)	2,186 bp
Tssr95066	Chr10:87696339-87696354 (+)	2,220 bp
Tssr95067	Chr10:87696686-87696692 (+)	2,562 bp
Tssr95068	Chr10:87696868-87696893 (+)	2,754 bp
Tssr95069	Chr10:87696939-87696971 (+)	2,828 bp
Tssr95070	Chr10:87697157-87697168 (+)	3,036 bp
Tssr95071	Chr10:87697171-87697200 (+)	3,059 bp
Tssr95072	Chr10:87699646-87699660 (+)	5,526 bp
Tssr95073	Chr10:87699890-87699931 (+)	5,784 bp
Tssr95074	Chr10:87700191-87700231 (+)	6,084 bp
Tssr95075	Chr10:87700584-87700723 (+)	6,527 bp
Tssr95076	Chr10:87700733-87700764 (+)	6,622 bp
Tssr95077	Chr10:87700882-87700899 (+)	6,764 bp
Tssr95078	Chr10:87707798-87707811 (+)	13,678 bp
Tssr95079	Chr10:87716676-87716687 (+)	22,555 bp
Tssr95080	Chr10:87716805-87716818 (+)	22,685 bp
Tssr95081	Chr10:87728276-87728278 (+)	34,150 bp
Tssr95082	Chr10:87728327-87728349 (+)	34,211 bp
Tssr95083	Chr10:87728356-87728375 (+)	34,239 bp
Tssr95084	Chr10:87728447-87728476 (+)	34,335 bp
Tssr95085	Chr10:87739828-87739853 (+)	45,714 bp
Tssr95086	Chr10:87742783-87742797 (+)	48,663 bp
Tssr95087	Chr10:87743827-87743839 (+)	49,706 bp
Tssr95088	Chr10:87749467-87749484 (+)	55,349 bp
Tssr95089	Chr10:87749488-87749501 (+)	55,368 bp
Tssr95090	Chr10:87749510-87749524 (+)	55,390 bp
Tssr95091	Chr10:87749526-87749546 (+)	55,409 bp
Tssr95092	Chr10:87749553-87749564 (+)	55,432 bp
Tssr95093	Chr10:87749566-87749598 (+)	55,455 bp
Tssr95094	Chr10:87749609-87749623 (+)	55,489 bp
Tssr95095	Chr10:87749628-87749631 (+)	55,503 bp
Tssr95096	Chr10:87750238-87750249 (+)	56,117 bp
Tssr95097	Chr10:87750254-87750275 (+)	56,138 bp
Tssr95098	Chr10:87750386-87750401 (+)	56,267 bp
Tssr95099	Chr10:87751149-87751175 (+)	57,035 bp
Tssr95100	Chr10:87752163-87752170 (+)	58,040 bp
Tssr95101	Chr10:87752220-87752238 (+)	58,102 bp
Tssr95102	Chr10:87752254-87752281 (+)	58,141 bp
Tssr95103	Chr10:87752289-87752300 (+)	58,168 bp
Tssr95104	Chr10:87752338-87752369 (+)	58,227 bp
Tssr95105	Chr10:87757457-87757461 (+)	63,332 bp
Tssr95106	Chr10:87759089-87759129 (+)	64,982 bp
Tssr95107	Chr10:87761124-87761128 (+)	66,999 bp
Tssr95108	Chr10:87762258-87762267 (+)	68,136 bp
Tssr95109	Chr10:87764957-87765007 (+)	70,855 bp
Tssr95110	Chr10:87765104-87765118 (+)	70,984 bp
Tssr95111	Chr10:87766549-87766559 (+)	72,427 bp
Tssr95112	Chr10:87766591-87766670 (+)	72,504 bp
Tssr95113	Chr10:87766717-87766734 (+)	72,599 bp
Tssr95114	Chr10:87766814-87766827 (+)	72,694 bp
Tssr95115	Chr10:87767002-87767031 (+)	72,890 bp
Tssr95116	Chr10:87767163-87767193 (+)	73,051 bp
Tssr95117	Chr10:87767204-87767216 (+)	73,083 bp
Tssr95118	Chr10:87767315-87767326 (+)	73,194 bp
Tssr95119	Chr10:87767340-87767351 (+)	73,219 bp
Tssr95120	Chr10:87767436-87767447 (+)	73,315 bp
Tssr95121	Chr10:87767934-87767946 (+)	73,813 bp
Tssr95122	Chr10:87768288-87768303 (+)	74,169 bp
Tssr95123	Chr10:87768638-87768650 (+)	74,517 bp
Tssr95124	Chr10:87768663-87768681 (+)	74,545 bp
Tssr95125	Chr10:87769059-87769071 (+)	74,938 bp
Tssr95126	Chr10:87769097-87769158 (+)	75,001 bp
Tssr95127	Chr10:87769194-87769233 (+)	75,087 bp
Tssr95128	Chr10:87769236-87769255 (+)	75,119 bp
Tssr95129	Chr10:87769571-87769587 (+)	75,452 bp
Tssr95130	Chr10:87769699-87769710 (+)	75,578 bp
Tssr95131	Chr10:87769869-87769907 (+)	75,761 bp
Tssr95132	Chr10:87770531-87770548 (+)	76,413 bp
Tssr95133	Chr10:87770682-87770712 (+)	76,570 bp
Tssr95134	Chr10:87771070-87771079 (+)	76,948 bp
Tssr95135	Chr10:87771769-87771792 (+)	77,654 bp
Tssr95136	Chr10:87771815-87771856 (+)	77,709 bp
Tssr95137	Chr10:87771951-87771962 (+)	77,830 bp

Igf1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bgeq8	Chr10, 66.75 cM		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.
Igfbp3q2	Chr10, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.
Insq9	Chr10, 39.72 cM	Chr10:82490938-82491121	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.

*cM position of peak correlated region/marker