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Igf1r Gene Detail
Summary
  • Symbol
    Igf1r
  • Name
    insulin-like growth factor I receptor
  • Synonyms
    A330103N21Rik, CD221, hyft, IGF-1R, line 186
  • Feature Type
    protein coding gene
  • IDs
    MGI:96433
    NCBI Gene: 16001
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:67602575-67883416 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 37.27 cM
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7828 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96433
 protein coding gene Chr7:67601486-67883416 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032362
 protein coding gene Chr7:69239233-69522551 (+)
A/J MGP_AJ_G0032341
 protein coding gene Chr7:67802426-68079791 (+)
AKR/J MGP_AKRJ_G0032277
 protein coding gene Chr7:69235953-69519068 (+)
BALB/cJ MGP_BALBcJ_G0032353
 protein coding gene Chr7:67546549-67823076 (+)
C3H/HeJ MGP_C3HHeJ_G0032066
 protein coding gene Chr7:69925355-70220670 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032845
 protein coding gene Chr7:72184994-72467942 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029853
 protein coding gene Chr7:70649322-70926328 (+)
CAST/EiJ MGP_CASTEiJ_G0031394
 protein coding gene Chr7:60593352-60901668 (+)
CBA/J MGP_CBAJ_G0032032
 protein coding gene Chr7:74453486-74738617 (+)
DBA/2J MGP_DBA2J_G0032187
 protein coding gene Chr7:66511368-66785386 (+)
FVB/NJ MGP_FVBNJ_G0032142
 protein coding gene Chr7:66631675-66908676 (+)
LP/J MGP_LPJ_G0032268
 protein coding gene Chr7:70459106-70737928 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032179
 protein coding gene Chr7:74654927-74945938 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032863
 protein coding gene Chr7:68606196-68896587 (+)
PWK/PhJ MGP_PWKPhJ_G0031114
 protein coding gene Chr7:59549128-59848005 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030955
 protein coding gene Chr7:55625714-55929186 (+)
WSB/EiJ MGP_WSBEiJ_G0031512
 protein coding gene Chr7:68941796-69223949 (+)



Homology
more
  • Human Ortholog
    IGF1R, insulin like growth factor 1 receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGF1R, insulin like growth factor 1 receptor
  • Synonyms
    CD221, IGFIR, IGFR, JTK13
  • Links
    NCBI Gene ID: 3480
    neXtProt AC: NX_P08069
    UniProt: P08069

  • Chr Location
    15q26.3; chr15:98648539-98964530 (+)  GRCh38
Human Diseases
more
  • Diseases
    15 with human IGF1R associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    90 phenotypes from 8 alleles in 16 genetic backgrounds
    48 phenotypes from multigenic genotypes
    232 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted null mutants die at birth of respiratory failure; fetuses exhibit retarded growth, organ hypoplasia, ossification delay and nervous system and epidermal abnormalities. hyft homozygous fetuses are growth retarded and exhibit hydrops fetalis and focal hepatic ischemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    163
  • GO References
    38
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    926
  • Tissues
    145
  • cDNA Data
    142
  • Literature Summary
    110
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005533 Ensembl Gene Model | MGI Sequence Detail 280842 C57BL/6J ±  kb
    transcript ENSMUST00000005671 Ensembl | MGI Sequence Detail 11409 Not Applicable  
    polypeptide ENSMUSP00000005671 Ensembl | MGI Sequence Detail 1369 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 168
      Genomic 1
      cDNA 148
      Primer pair 17
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-11229, MGI:1925023, MGI:3576016
    References
    more
    • Summaries
      All 492
      Developmental Gene Expression 110
      Gene Ontology 38
      Phenotypes 232
    • Earliest
      J:9941 Sundaresan S, et al., Insulin-like growth factor I receptor gene is concordant with c-Fes protooncogene and mouse chromosome 7 in somatic cell hybrids. Somat Cell Mol Genet. 1989 Jul;15(4):373-6
    • Latest
      J:353388 Douglas JC, et al., Normal Ovarian Function in Subfertile Mouse with Amhr2-Cre-Driven Ablation of Insr and Igf1r. Genes (Basel). 2024 May 12;15(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory