Igfbp4 MGI Mouse Gene Detail - MGI:96439 - insulin-like growth factor binding protein 4

Symbol

Igfbp4
Name

insulin-like growth factor binding protein 4
Synonyms

Band 3A, Deb2, IGFBP-4

Feature Type

protein coding gene
IDs

MGI:96439
NCBI Gene: 16010
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr11:98930820-98943481 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 62.92 cM
Mapping Data

3 experiments

SNPs within 2kb

403 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96439	protein coding gene	Chr11:98930820-98945218 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019081	protein coding gene	Chr11:101674985-101691666 (+)
A/J	MGP_AJ_G0019049	protein coding gene	Chr11:97405171-97418632 (+)
AKR/J	MGP_AKRJ_G0019019	protein coding gene	Chr11:100423272-100436949 (+)
BALB/cJ	MGP_BALBcJ_G0019023	protein coding gene	Chr11:97897807-97911223 (+)
C3H/HeJ	MGP_C3HHeJ_G0018836	protein coding gene	Chr11:100569421-100584276 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019474	protein coding gene	Chr11:104812099-104826250 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017106	protein coding gene	Chr11:94962753-94975918 (+)
CAST/EiJ	MGP_CASTEiJ_G0018390	protein coding gene	Chr11:101557717-101575327 (+)
CBA/J	MGP_CBAJ_G0018807	protein coding gene	Chr11:109159968-109175165 (+)
DBA/2J	MGP_DBA2J_G0018915	protein coding gene	Chr11:96964781-96978401 (+)
FVB/NJ	MGP_FVBNJ_G0018904	protein coding gene	Chr11:96481746-96496700 (+)
LP/J	MGP_LPJ_G0018985	protein coding gene	Chr11:102139219-102152205 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018931	protein coding gene	Chr11:108840193-108855875 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019514	protein coding gene	Chr11:100783650-100797992 (+)
PWK/PhJ	MGP_PWKPhJ_G0018161	protein coding gene	Chr11:98021265-98039049 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017950	protein coding gene	Chr11:100532763-100544750 (+)
WSB/EiJ	MGP_WSBEiJ_G0018439	protein coding gene	Chr11:100746470-100760727 (+)

Human Ortholog

IGFBP4, insulin like growth factor binding protein 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IGFBP4, insulin like growth factor binding protein 4
Synonyms

BP-4, HT29-IGFBP, IBP4, IGFBP-4
Links

HGNC:5473

NCBI Gene ID: 3487

neXtProt AC: NX_P22692

UniProt: P22692
Chr Location

17q21.2; chr17:40443450-40457725 (+) GRCh38

MGI Vertebrate Homology

Igfbp4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IGFBP4
Gene Tree

Igfbp4

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotypes from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

5
Genomic Mutations

1 involving Igfbp4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit a similar reduction in birth and postnatal body weight, and show impaired glucose homeostasis relative to wild-type controls.

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All GO Annotations

24
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

69
cDNA Data

480
Literature Summary

44

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase igfbp4

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All Sequences

63
RefSeq

8
UniProt

4
CCDS

CCDS25371.1

Ensembl

ENSMUSG00000017493 (Evidence)
NCBI Gene

16010

			Length	Strain/Species	Flank
genomic	16010	NCBI Gene Model \| MGI Sequence Detail	12662	C57BL/6J	± kb
transcript	NM_010517	RefSeq \| MGI Sequence Detail	2108	C57BL/6
polypeptide	P47879	UniProt \| EBI \| MGI Sequence Detail	254	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008950 insulin-like growth factor-binding protein 4

(term hierarchy)
InterPro Domains

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR022327 Insulin-like growth factor-binding protein 4

IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata

IPR000867 Insulin-like growth factor-binding protein, IGFBP

IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site

IPR000716 Thyroglobulin type-1

IPR036857 Thyroglobulin type-1 superfamily
GlyGen

P47879 1 site

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All nucleic 490

Genomic 1

cDNA 481

Primer pair 6

Other 2

Microarray probesets 10

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MGD-MRK-11236, MGI:1349476, MGI:2144326

Summaries

All 113

Developmental Gene Expression 44

Gene Ontology 7

Phenotypes 18
Earliest

J:3735 Donahue LR, et al., Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J Endocrinol. 1993 Jan;136(1):91-104
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Igfbp4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104840	Chr11:98932063-98932080 (+)	1,252 bp
Tssr104841	Chr11:98932088-98932093 (+)	1,271 bp
Tssr104842	Chr11:98932723-98932764 (+)	1,924 bp
Tssr104843	Chr11:98935950-98935955 (+)	5,133 bp
Tssr104844	Chr11:98938141-98938152 (+)	7,327 bp
Tssr104845	Chr11:98938905-98938942 (+)	8,104 bp
Tssr104846	Chr11:98942265-98942279 (+)	11,452 bp
Tssr104847	Chr11:98942359-98942371 (+)	11,545 bp
Tssr104848	Chr11:98942455-98942519 (+)	11,667 bp
Tssr104849	Chr11:98942622-98942644 (+)	11,813 bp
Tssr104850	Chr11:98942935-98942961 (+)	12,128 bp
Tssr104851	Chr11:98943005-98943016 (+)	12,191 bp
Tssr104852	Chr11:98943138-98943164 (+)	12,331 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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