Igh Complex/Cluster/Region Detail

Summary

• Symbol
  Igh
• Name
  immunoglobulin heavy chain complex

• Feature Type
  complex/cluster/region
  BioType Conflict
  
• IDs
  MGI:96442
  NCBI Gene: 111507
• Regulated by
  Rr91, Rr152, Rr156 ... (14 regulatory regions)

Location &
Maps

• Sequence Map
  Chr12:113222388-115973574 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 12, Syntenic
• Mapping Data
  26 experiments

Strain
Comparison

• SNPs within 2kb
  91840 from dbSNP Build 142
• PCR
  10
• RFLP
  4

Human Diseases

• Mutations/Alleles
  5 with disease annotations

• References
  5 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  77 phenotypes from 42 alleles in 32 genetic backgrounds
  118 phenotypes from multigenic genotypes
  519 phenotype references
  

• All Mutations and Alleles
  131
• Endonuclease-mediated
  7
• Targeted
  102
• Transgenic
  20
• Genomic Mutations
  11 involving Igh
• Find Mice (IMSR)
  39 strains or lines available

Mice homozygous for a knock-out allele exhibit abnormal B cell morphology and physiology.

Sequences &
Gene Models

• All Sequences
  2
• RefSeq
  1

• NCBI Gene
  111507

Representative Sequences			Length	Strain/Species
genomic	111507	NCBI Gene Model | MGI Sequence Detail	2751187	C57BL/6J

Molecular
Reagents

• All nucleic 11

  Genomic 2

  cDNA 2

  Primer pair 6

  Other 1

Other
Accession IDs

MGD-MRK-11239

References

• Summaries
  All 680

  Diseases 5

  Phenotypes 519
• Earliest
  J:284952 Bosma MJ, et al., Congenic mouse strains: the expression of a hidden immunoglobulin allotype in a congenic partner strain of BALB-c mice. J Exp Med. 1974;139(3):512-27
• Latest
  J:364539 Luo X, et al., An interleukin-9-ZBTB18 axis promotes germinal center development of memory B cells. Immunity. 2025 Apr 8;58(4):861-874.e6

Igh expression regulated by:

Feature	Feature Type	Location	Reference
Rr91, regulatory region 91	CTCF binding site	Chr12:113185086-113188506	J:181838
Rr152, regulatory region 152	enhancer	Chr12:113191890-113217660	J:234741
Rr156, regulatory region 156	enhancer	Chr12:113191890-113191986	J:234741
Rr155, regulatory region 155	enhancer	Chr12:113195964-113196046	J:234741
Rr153, regulatory region 153	enhancer	Chr12:113208282-113208364	J:234741
Rr154, regulatory region 154	enhancer	Chr12:113217466-113217660	J:234741
Rr555, regulatory region 555	matrix attachment site	Chr12:113390595-113391026	J:342746
Rr150, regulatory region 150	enhancer	Chr12:113390871-113391349	J:292184
Rr148, regulatory region 148	enhancer	Chr12:113391013-113391258	J:292184
Rr149, regulatory region 149	transcription factor binding site	Chr12:113391193-113391206	J:292184
Rr554, regulatory region 554	matrix attachment site	Chr12:113391243-113391592	J:342746
Rr151, regulatory region 151	enhancer	Chr12, Syntenic	J:118453
Rr362, regulatory region 362	insulator	Chr12, Syntenic	J:220021
Rr363, regulatory region 363	insulator	Chr12, Syntenic	J:333305