Jchain MGI Mouse Gene Detail - MGI:96493 - immunoglobulin joining chain

Symbol

Jchain
Name

immunoglobulin joining chain
Synonyms

9530090F24Rik, Igj, Jch, J chain

Feature Type

protein coding gene
IDs

MGI:96493
NCBI Gene: 16069
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:88667663-88675667 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 43.70 cM
Mapping Data

3 experiments

SNPs within 2kb

314 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96493	protein coding gene	Chr5:88667663-88675750 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029708	protein coding gene	Chr5:89519699-89528343 (-)
A/J	MGP_AJ_G0029674	protein coding gene	Chr5:85978775-85986996 (-)
AKR/J	MGP_AKRJ_G0029620	protein coding gene	Chr5:88818086-88826167 (-)
BALB/cJ	MGP_BALBcJ_G0029684	protein coding gene	Chr5:86896237-86906100 (-)
C3H/HeJ	MGP_C3HHeJ_G0029407	protein coding gene	Chr5:89168579-89176734 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030138	protein coding gene	Chr5:93157653-93167143 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027374	protein coding gene	Chr5:81799121-81807176 (-)
CAST/EiJ	MGP_CASTEiJ_G0028817	protein coding gene	Chr5:88593850-88606074 (-)
CBA/J	MGP_CBAJ_G0029376	protein coding gene	Chr5:96257396-96268379 (-)
DBA/2J	MGP_DBA2J_G0029521	protein coding gene	Chr5:86060630-86068798 (-)
FVB/NJ	MGP_FVBNJ_G0029480	protein coding gene	Chr5:84973140-84981498 (-)
LP/J	MGP_LPJ_G0029609	protein coding gene	Chr5:89915487-89925331 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029509	protein coding gene	Chr5:101295457-101305474 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030172	protein coding gene	Chr5:88344891-88354332 (-)
PWK/PhJ	MGP_PWKPhJ_G0028536	protein coding gene	Chr5:85147694-85155816 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028371	protein coding gene	Chr5:87764665-87772617 (-)
WSB/EiJ	MGP_WSBEiJ_G0028896	protein coding gene	Chr5:88734650-88743058 (-)

Human Ortholog

JCHAIN, joining chain of multimeric IgA and IgM

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

JCHAIN, joining chain of multimeric IgA and IgM
Synonyms

IGCJ, IGJ, JCH
Links

HGNC:5713

NCBI Gene ID: 3512

neXtProt AC: NX_P01591

UniProt: P01591
Chr Location

4q13.3; chr4:70655541-70681817 (-) GRCh38

MGI Vertebrate Homology

Jchain stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: JCHAIN
Gene Tree

Jchain

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Phenotype Summary

9 phenotypes from 2 alleles in 3 genetic backgrounds
9 phenotypes from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

5
Radiation induced

1
Spontaneous

1
Targeted

9
Genomic Mutations

6 involving Jchain
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show increased IgA level and alterations in IgA transport and in susceptibility to viral and parasitic infections. Homozygotes for another null allele show increased IgA level, decreased IgM level, reduced numbers of IgM plasma cells, and impaired IgM immune responses.

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All GO Annotations

41
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

745
Tissues

14
cDNA Data

111
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

1
CCDS

CCDS19401.1

Ensembl

ENSMUSG00000067149 (Evidence)
NCBI Gene

16069

			Length	Strain/Species	Flank
genomic	16069	NCBI Gene Model \| MGI Sequence Detail	8005	C57BL/6J	± kb
transcript	NM_152839	RefSeq \| MGI Sequence Detail	2018	C57BL/6
polypeptide	P01592	UniProt \| EBI \| MGI Sequence Detail	159	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008965 immunoglobulin J chain

(term hierarchy)
PDB

7JG1, 7JG2
InterPro Domains

IPR024110 Immunoglobulin J chain
GlyGen

P01592 2 sites, 5 N-linked glycans (1 site), 1 O-linked glycan (1 site)

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All nucleic 113

cDNA 111

Primer pair 2

Microarray probesets 3

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MGD-MRK-11291, MGI:1915537, MGI:2140835

Summaries

All 63

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 28
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Jchain:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr51683	Chr5:88675700-88675711 (-)	-39 bp
Tssr51682	Chr5:88675654-88675679 (-)	0 bp
Tssr51681	Chr5:88674376-88674399 (-)	1,279 bp
Tssr51680	Chr5:88674355-88674365 (-)	1,307 bp
Tssr51679	Chr5:88670393-88670414 (-)	5,263 bp
Tssr51678	Chr5:88669065-88669068 (-)	6,600 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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