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Igkrs Gene Detail
Summary
  • Symbol
    Igkrs
  • Name
    immunoglobulin kappa chain recombining segment
  • Synonyms
    Igk-rs
  • Feature Type
    gene segment
  • IDs
    MGI:96521
    NCBI Gene: 110754
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 6, Syntenic
  • Mapping Data
    5 experiments
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal immunoglobulin light chain V-J recombination and show a significant reduction in the number of both immature and mature B cells that express lambda chain.
Gene Ontology
(GO)
Classifications
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Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Sequences &
Gene Models
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Molecular
Reagents
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  • All nucleic 10
    Genomic 10
Other
Accession IDs
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MGD-MRK-11298, MGD-MRK-11326
References
more
  • Summaries
    All 10
    Phenotypes 2
  • Earliest
    J:8644 Siminovitch KA, et al., The human kappa deleting element and the mouse recombining segment share DNA sequence homology. Nucleic Acids Res. 1987 Mar 25;15(6):2699-705
  • Latest
    J:181249 Aoki-Ota M, et al., Skewed primary igkappa repertoire and v-j joining in C57BL/6 mice: implications for recombination accessibility and receptor editing. J Immunol. 2012 Mar 1;188(5):2305-15
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory