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Il1b Gene Detail
Summary
  • Symbol
    Il1b
  • Name
    interleukin 1 beta
  • Synonyms
    IL-1B, IL-1beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:96543
    NCBI Gene: 16176
  • Member of
    Il1 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:129206490-129213059 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 62.97 cM, cytoband F
  • Mapping Data
    32 experiments
Strain
Comparison
more
  • SNPs within 2kb
    295 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    7
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96543
 protein coding gene Chr2:129206490-129213059 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026488
 protein coding gene Chr2:132756357-132762923 (-)
A/J MGP_AJ_G0026452
 protein coding gene Chr2:127373484-127380053 (-)
AKR/J MGP_AKRJ_G0026427
 protein coding gene Chr2:130987117-130993683 (-)
BALB/cJ MGP_BALBcJ_G0026464
 protein coding gene Chr2:127630840-127637653 (-)
C3H/HeJ MGP_C3HHeJ_G0026207
 protein coding gene Chr2:131501934-131508502 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026909
 protein coding gene Chr2:136904604-136911167 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024286
 protein coding gene Chr2:122187052-122193417 (-)
CAST/EiJ MGP_CASTEiJ_G0025668
 protein coding gene Chr2:131758351-131764844 (-)
CBA/J MGP_CBAJ_G0026187
 protein coding gene Chr2:141966195-141972763 (-)
DBA/2J MGP_DBA2J_G0026321
 protein coding gene Chr2:126763085-126769654 (-)
FVB/NJ MGP_FVBNJ_G0026285
 protein coding gene Chr2:125409080-125415646 (-)
LP/J MGP_LPJ_G0026426
 protein coding gene Chr2:132991823-132998389 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026305
 protein coding gene Chr2:145861769-145868339 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026964
 protein coding gene Chr2:131032064-131038630 (-)
PWK/PhJ MGP_PWKPhJ_G0025404
 protein coding gene Chr2:126344436-126351116 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025207
 protein coding gene Chr2:130153763-130160192 (-)
WSB/EiJ MGP_WSBEiJ_G0025742
 protein coding gene Chr2:131955502-131963394 (-)



Homology
more
  • Human Ortholog
    IL1B, interleukin 1 beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL1B, interleukin 1 beta
  • Synonyms
    IL-1, IL1-BETA, IL1beta, IL1F2
  • Links
    NCBI Gene ID: 3553
    neXtProt AC: NX_P01584
    UniProt: P01584

  • Chr Location
    2q14.1; chr2:112829751-112836816 (-)  GRCh38
Human Diseases
more
  • Diseases
    37 with human IL1B associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 3 alleles in 9 genetic backgrounds
    9 phenotypes from multigenic genotypes
    297 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants show impaired contact hypersensitivity and reduced acute-phase inflammatory response. Lung tumors and metastases of B16 melanoma do not occur in null mutant mice, suggesting inability to support tumor invasiveness and angiogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    186
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    845
  • Tissues
    74
  • cDNA Data
    14
  • Literature Summary
    83
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16176 NCBI Gene Model | MGI Sequence Detail 6570 C57BL/6J ±  kb
    transcript NM_008361 RefSeq | MGI Sequence Detail 1348 ZRU/MplStud  
    polypeptide P10749 UniProt | EBI | MGI Sequence Detail 269 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 4
      cDNA 14
      Primer pair 16
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11352, MGD-MRK-11367
    References
    more
    • Summaries
      All 890
      Developmental Gene Expression 83
      Gene Ontology 35
      Phenotypes 297
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:357569 Gao H, et al., Gasdermin D promotes development of intestinal tumors through regulating IL-1beta release and gut microbiota composition. Cell Commun Signal. 2024 Oct 21;22(1):511
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory