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Il1r1 Gene Detail
Summary
  • Symbol
    Il1r1
  • Name
    interleukin 1 receptor, type I
  • Synonyms
    CD121a, Il1r-1, IL-1R1, IL-1 receptor alpha chain, IL-iR
  • Feature Type
    protein coding gene
  • IDs
    MGI:96545
    NCBI Gene: 16177
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:40264240-40356417 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 18.81 cM
  • Mapping Data
    26 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2885 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96545
 protein coding gene Chr1:40261651-40356417 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015965
 protein coding gene Chr1:39009644-39103597 (+)
A/J MGP_AJ_G0015949
 protein coding gene Chr1:37907097-37998112 (+)
AKR/J MGP_AKRJ_G0015904
 protein coding gene Chr1:38396784-38489502 (+)
BALB/cJ MGP_BALBcJ_G0015903
 protein coding gene Chr1:37561115-37657094 (+)
C3H/HeJ MGP_C3HHeJ_G0015736
 protein coding gene Chr1:38680247-38775382 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016356
 protein coding gene Chr1:40612725-40709659 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014078
 protein coding gene Chr1:34842407-34931699 (+)
CAST/EiJ MGP_CASTEiJ_G0015317
 protein coding gene Chr1:38585465-38677624 (+)
CBA/J MGP_CBAJ_G0015708
 protein coding gene Chr1:41817742-41919244 (+)
DBA/2J MGP_DBA2J_G0015809
 protein coding gene Chr1:37181649-37275516 (+)
FVB/NJ MGP_FVBNJ_G0015811
 protein coding gene Chr1:36737675-36826917 (+)
LP/J MGP_LPJ_G0015879
 protein coding gene Chr1:39345033-39437756 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015831
 protein coding gene Chr1:43828909-43923351 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016403
 protein coding gene Chr1:38542307-38637415 (+)
PWK/PhJ MGP_PWKPhJ_G0015100
 protein coding gene Chr1:37006057-37097290 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014882
 protein coding gene Chr1:38472802-38580664 (+)
WSB/EiJ MGP_WSBEiJ_G0015379
 protein coding gene Chr1:38504305-38606756 (+)



Homology
more
  • Human Ortholog
    IL1R1, interleukin 1 receptor type 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL1R1, interleukin 1 receptor type 1
  • Synonyms
    CD121A, CRMO3, D2S1473, IL1R, IL1RA, IL-1R-alpha, IL-1RT1, P80
  • Links
    NCBI Gene ID: 3554
    neXtProt AC: NX_P14778
    UniProt: P14778

  • Chr Location
    2q11.2-q12.1; chr2:102064544-102179874 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Il1r1 mouse models; 3 with human IL1R1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    78 phenotypes from 7 alleles in 16 genetic backgrounds
    45 phenotypes from multigenic genotypes
    596 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection, reduced IL1b responsiveness, delayed tooth eruption, decreased susceptibility to experimental autoimmune uveoretinitis, decreased susceptibility to kidney reperfusion injury, and late onset obesity. Homozygosity for a mutation associated with arthritis in human leads to severe sensitivity to collagen antibody-induced arthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    34
  • cDNA Data
    30
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026072 Ensembl Gene Model | MGI Sequence Detail 92178 C57BL/6J ±  kb
    transcript ENSMUST00000027241 Ensembl | MGI Sequence Detail 5819 Not Applicable  
    polypeptide ENSMUSP00000027241 Ensembl | MGI Sequence Detail 576 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 30
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11369, MGD-MRK-11371
    References
    more
    • Summaries
      All 776
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 20
      Phenotypes 596
    • Earliest
      J:22685 Sims JE, et al., cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science. 1988 Jul 29;241(4865):585-9
    • Latest
      J:354893 Fidler TP, et al., Suppression of IL-1beta promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis. Nat Cardiovasc Res. 2024 Jan;3(1):60-75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory