Il1r2 MGI Mouse Gene Detail - MGI:96546 - interleukin 1 receptor, type II

Symbol

Il1r2
Name

interleukin 1 receptor, type II
Synonyms

CD121b, Il1r-2, IL-1 receptor beta chain

Feature Type

protein coding gene
IDs

MGI:96546
NCBI Gene: 16178
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:40123872-40164390 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 18.65 cM
Mapping Data

4 experiments

SNPs within 2kb

1311 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96546	protein coding gene	Chr1:40113239-40164391 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015964	protein coding gene	Chr1:38857528-38915750 (+)
A/J	MGP_AJ_G0015948	protein coding gene	Chr1:37755502-37808070 (+)
AKR/J	MGP_AKRJ_G0015903	protein coding gene	Chr1:38247589-38306433 (+)
BALB/cJ	MGP_BALBcJ_G0015902	protein coding gene	Chr1:37417115-37471738 (+)
C3H/HeJ	MGP_C3HHeJ_G0015735	protein coding gene	Chr1:38536407-38591062 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016355	protein coding gene	Chr1:40450369-40509628 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014077	protein coding gene	Chr1:34702083-34752965 (+)
CAST/EiJ	MGP_CASTEiJ_G0015316	protein coding gene	Chr1:38443747-38498635 (+)
CBA/J	MGP_CBAJ_G0015707	protein coding gene	Chr1:41634125-41702042 (+)
DBA/2J	MGP_DBA2J_G0015808	protein coding gene	Chr1:37043816-37095700 (+)
FVB/NJ	MGP_FVBNJ_G0015810	protein coding gene	Chr1:36585635-36640990 (+)
LP/J	MGP_LPJ_G0015878	protein coding gene	Chr1:39191809-39248543 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015830	protein coding gene	Chr1:43665181-43725355 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016402	protein coding gene	Chr1:38396643-38452170 (+)
PWK/PhJ	MGP_PWKPhJ_G0015099	protein coding gene	Chr1:36867682-36921071 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014881	protein coding gene	Chr1:38339291-38390386 (+)
WSB/EiJ	MGP_WSBEiJ_G0015378	protein coding gene	Chr1:38353083-38410574 (+)

Human Ortholog

IL1R2, interleukin 1 receptor type 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL1R2, interleukin 1 receptor type 2
Synonyms

CD121b, CDw121b, IL-1R-2, IL1R2c, IL1RB, IL-1RT-2, IL-1RT2
Links

HGNC:5994

NCBI Gene ID: 7850

neXtProt AC: NX_P27930

UniProt: P27930
Chr Location

2q11.2; chr2:101991960-102028544 (+) GRCh38

MGI Vertebrate Homology

Il1r2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IL1R2
Gene Tree

Il1r2

Diseases

4 with human IL1R2 associations

				Human Disease	Mouse Models
				aggressive periodontitis IDs aggressive periodontitis DOID:1474 ICD10CM:K05.2 MESH:D010520 OMIM:170650 OMIM:608526 UMLS_CUI:C0031106
				esophageal cancer IDs esophageal cancer DOID:5041 DOID:10291 DOID:10292 DOID:10448 DOID:1102 DOID:1104 ICD10CM:C15.3 ICD10CM:C15.4 ICD10CM:C15.5 ICD9CM:150.2 ICD9CM:150.3 ICD9CM:150.4 ICD9CM:150.5 ICD9CM:150.8 MESH:D004938 NCI:C3028 NCI:C3533 NCI:C3534 NCI:C3535 NCI:C4764 OMIM:133239 UMLS_CUI:C0014859 UMLS_CUI:C0153413 UMLS_CUI:C0153414 UMLS_CUI:C0153415 UMLS_CUI:C0153416 UMLS_CUI:C0496775
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493
				organ system cancer IDs organ system cancer DOID:0050686 MESH:D009371

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

17 phenotypes from 5 alleles in 5 genetic backgrounds
1 phenotype from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

10
Genomic Mutations

1 involving Il1r2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show a prolonged inflammatory response in response to IL-1a. Mice show increased CD4+ T cell number and altered CD8 subtype ratio following sRBC immunization. Another null allele shows increased susceptibility to induced arthritis.

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

20
cDNA Data

16
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase il1r2

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All Sequences

60
RefSeq

22
UniProt

5
CCDS

CCDS14909.1

Ensembl

ENSMUSG00000026073 (Evidence)
NCBI Gene

16178

			Length	Strain/Species	Flank
genomic	16178	NCBI Gene Model \| MGI Sequence Detail	40519	C57BL/6J	± kb
transcript	NM_001360800	RefSeq \| MGI Sequence Detail	1646	C57BL/6
polypeptide	P27931	UniProt \| EBI \| MGI Sequence Detail	410	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000001364 interleukin-1 receptor type 2

(term hierarchy)
InterPro Domains

IPR041416 IL-1Ra-like, immunoglobulin domain

IPR013151 Immunoglobulin

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR015621 Interleukin-1 receptor family

IPR004077 Interleukin-1 receptor type II

IPR004074 Interleukin-1 receptor type I/II
GlyGen

P27931 4 sites

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All nucleic 17

cDNA 16

Primer pair 1

Microarray probesets 4

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MGD-MRK-11370, MGD-MRK-11372

Summaries

All 69

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 16
Earliest

J:14586 Chizzonite R, et al., Two high-affinity interleukin 1 receptors represent separate gene products. Proc Natl Acad Sci U S A. 1989 Oct;86(20):8029-33
Latest

J:354879 Belbezier A, et al., Interleukin-1 regulates follicular T cells during the germinal center reaction. Front Immunol. 2024;15:1393096

TSS for Il1r2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr62	Chr1:40123870-40123877 (+)	2 bp
Tssr6411	Chr1:40123893-40123909 (+)	29 bp
Tssr6412	Chr1:40123924-40123930 (+)	55 bp
Tssr6413	Chr1:40123935-40123944 (+)	68 bp
Tssr6414	Chr1:40124358-40124388 (+)	501 bp
Tssr6415	Chr1:40125251-40125254 (+)	1,381 bp
Tssr6416	Chr1:40140535-40140538 (+)	16,665 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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