Il5 MGI Mouse Gene Detail - MGI:96557

Symbol

Il5
Name

interleukin 5
Synonyms

Il-5

Feature Type

protein coding gene
IDs

MGI:96557
NCBI Gene: 16191
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr11:53611621-53615930 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 31.99 cM, cytoband A5/B1
Mapping Data

31 experiments

SNPs within 2kb

268 from dbSNP Build 142
Strain Annotations

18
PCR

12
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96557	protein coding gene	Chr11:53611621-53615933 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018303	protein coding gene	Chr11:53133035-53137348 (+)
A/J	MGP_AJ_G0018272	protein coding gene	Chr11:51126963-51131276 (+)
AKR/J	MGP_AKRJ_G0018242	protein coding gene	Chr11:52796560-52800819 (+)
BALB/cJ	MGP_BALBcJ_G0018243	protein coding gene	Chr11:51482762-51487075 (+)
C3H/HeJ	MGP_C3HHeJ_G0018054	protein coding gene	Chr11:52763325-52767638 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018695	protein coding gene	Chr11:54730505-54734818 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016345	protein coding gene	Chr11:48658910-48662979 (+)
CAST/EiJ	MGP_CASTEiJ_G0017619	protein coding gene	Chr11:52812759-52817087 (+)
CBA/J	MGP_CBAJ_G0018029	protein coding gene	Chr11:57332858-57337171 (+)
DBA/2J	MGP_DBA2J_G0018139	protein coding gene	Chr11:50873473-50877715 (+)
FVB/NJ	MGP_FVBNJ_G0018131	protein coding gene	Chr11:50515877-50520120 (+)
LP/J	MGP_LPJ_G0018213	protein coding gene	Chr11:53582191-53586504 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018155	protein coding gene	Chr11:58616351-58621541 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018737	protein coding gene	Chr11:52832744-52837059 (+)
PWK/PhJ	MGP_PWKPhJ_G0017394	protein coding gene	Chr11:51391197-51395425 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017189	protein coding gene	Chr11:52626945-52631194 (+)
WSB/EiJ	MGP_WSBEiJ_G0017666	protein coding gene	Chr11:52460659-52464940 (+)

Human Ortholog

IL5, interleukin 5

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL5, interleukin 5
Synonyms

EDF, IL-5, TRF
Links

HGNC:6016

NCBI Gene ID: 3567

neXtProt AC: NX_P05113

UniProt: P05113
Chr Location

5q31.1; chr5:132541445-132556838 (-) GRCh38

MGI Vertebrate Homology

Il5 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IL5
Gene Tree

Il5

Diseases

2 with human IL5 associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				stomach cancer IDs stomach cancer DOID:10534 DOID:10539 DOID:10542 DOID:10543 DOID:4713 ICD10CM:C16 ICD10CM:C16.2 ICD10CM:C16.5 ICD10CM:C16.6 ICD9CM:151 ICD9CM:151.4 ICD9CM:151.5 ICD9CM:151.6 ICD9CM:151.9 MESH:D013274 NCI:C3387 NCI:C9331 OMIM:613659 UMLS_CUI:C0024623 UMLS_CUI:C0038356 UMLS_CUI:C0153421 UMLS_CUI:C0153422 UMLS_CUI:C0153423

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

39 phenotypes from 6 alleles in 7 genetic backgrounds
13 phenotypes from multigenic genotypes
231 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

6
Targeted

8
Transgenic

6
Genomic Mutations

1 involving Il5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit loss of normal airway hyperreactivity resulting from aeroallergen challenge, reduced numbers of CD5+ B cells in the peritoneal cavity at 2 weeks, and some altered responses to schistosomiasis infection.

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All GO Annotations

28
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

20
cDNA Data

11
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

3
CCDS

CCDS24685.1

Ensembl

ENSMUSG00000036117 (Evidence)
NCBI Gene

16191

			Length	Strain/Species	Flank
genomic	16191	NCBI Gene Model \| MGI Sequence Detail	4310	C57BL/6J	± kb
transcript	NM_010558	RefSeq \| MGI Sequence Detail	1534	Not Specified
polypeptide	P04401	UniProt \| EBI \| MGI Sequence Detail	133	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001392 interleukin-5

(term hierarchy)
PDB

3B5K
InterPro Domains

IPR009079 Four-helical cytokine-like, core

IPR000186 Interleukin-5

IPR051392 Interleukin-5 Cytokine
GlyGen

P04401 3 sites

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All nucleic 38

Genomic 11

cDNA 16

Primer pair 8

Other 3

Microarray probesets 3

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MGD-MRK-11356, MGD-MRK-11387

Summaries

All 376

Developmental Gene Expression 7

Gene Ontology 15

Phenotypes 231
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:353914 Bessell E, et al., Stromal cell and B cell dialogue potentiates IL-33-enriched lymphoid niches to support eosinophil recruitment and function during type 2 immunity. Cell Rep. 2024 Aug 27;43(8):114620

TSS for Il5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101432	Chr11:53610271-53610287 (+)	-1,342 bp
Tssr101433	Chr11:53610787-53610801 (+)	-827 bp
Tssr101434	Chr11:53610817-53610831 (+)	-797 bp
Tssr101435	Chr11:53610837-53610854 (+)	-775 bp
Tssr101436	Chr11:53610908-53610915 (+)	-709 bp
Tssr101437	Chr11:53611617-53611622 (+)	-1 bp
Tssr101438	Chr11:53612730-53612756 (+)	1,122 bp
Tssr101439	Chr11:53614559-53614574 (+)	2,946 bp
Tssr101440	Chr11:53614595-53614617 (+)	2,985 bp
Tssr101441	Chr11:53614765-53614782 (+)	3,153 bp
Tssr101442	Chr11:53614822-53614851 (+)	3,216 bp
Tssr101443	Chr11:53614926-53614938 (+)	3,311 bp
Tssr101444	Chr11:53615324-53615335 (+)	3,709 bp
Tssr101445	Chr11:53615412-53615426 (+)	3,798 bp
Tssr101446	Chr11:53615445-53615466 (+)	3,835 bp
Tssr101447	Chr11:53615481-53615482 (+)	3,861 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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