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Il5ra Gene Detail
Summary
  • Symbol
    Il5ra
  • Name
    interleukin 5 receptor, alpha
  • Synonyms
    CD125, CDw125, Il5r, IL-5 receptor alpha chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:96558
    NCBI Gene: 16192
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:106687336-106725998 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 49.19 cM
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1253 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96558
 protein coding gene Chr6:106687318-106725998 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031094
 protein coding gene Chr6:108947968-108986499 (-)
A/J MGP_AJ_G0031063
 protein coding gene Chr6:104775963-104814632 (-)
AKR/J MGP_AKRJ_G0030994
 protein coding gene Chr6:107602743-107643503 (-)
BALB/cJ MGP_BALBcJ_G0031074
 protein coding gene Chr6:104732362-104770945 (-)
C3H/HeJ MGP_C3HHeJ_G0030634
 protein coding gene Chr6:76685593-76727059 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031533
 protein coding gene Chr6:111783834-111823803 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028697
 protein coding gene Chr6:102237578-102276812 (-)
CAST/EiJ MGP_CASTEiJ_G0030181
 protein coding gene Chr6:108015858-108058644 (-)
CBA/J MGP_CBAJ_G0030760
 protein coding gene Chr6:116120209-116160641 (-)
DBA/2J MGP_DBA2J_G0030913
 protein coding gene Chr6:103911158-103950238 (-)
FVB/NJ MGP_FVBNJ_G0030867
 protein coding gene Chr6:103009022-103047822 (-)
LP/J MGP_LPJ_G0030993
 protein coding gene Chr6:109035488-109075779 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030901
 protein coding gene Chr6:120376415-120417485 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031560
 protein coding gene Chr6:107597833-107638979 (-)
PWK/PhJ MGP_PWKPhJ_G0029897
 protein coding gene Chr6:102908921-102949913 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029725
 protein coding gene Chr6:106427768-106467356 (-)
WSB/EiJ MGP_WSBEiJ_G0030265
 protein coding gene Chr6:108121009-108161216 (-)



Homology
more
  • Human Ortholog
    IL5RA, interleukin 5 receptor subunit alpha
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL5RA, interleukin 5 receptor subunit alpha
  • Synonyms
    CD125, CDw125, HSIL5R3, IL5R
  • Links
    NCBI Gene ID: 3568
    neXtProt AC: NX_Q01344
    UniProt: Q01344

  • Chr Location
    3p26.2; chr3:3066324-3126613 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IL5RA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a generally normal phenotype but with some immune system deficiencies. Mice homozygous for one knock-out allele exhibit increased metastasis of injected B16F10 melanoma cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    12
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16192 NCBI Gene Model | MGI Sequence Detail 38663 C57BL/6J ±  kb
    transcript NM_008370 RefSeq | MGI Sequence Detail 3557 ZRU/MplStud  
    polypeptide P21183 UniProt | EBI | MGI Sequence Detail 415 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 5
      cDNA 12
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11388, MGD-MRK-11389
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 22
    • Earliest
      J:10912 Takaki S, et al., Molecular cloning and expression of the murine interleukin-5 receptor. EMBO J. 1990 Dec;9(13):4367-74
    • Latest
      J:354611 Lee D, et al., IL-10(+) regulatory B cells mitigate atopic dermatitis by suppressing eosinophil activation. Sci Rep. 2024 Aug 6;14(1):18164
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory