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Il6 Gene Detail
Summary
  • Symbol
    Il6
  • Name
    interleukin 6
  • Synonyms
    Il-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:96559
    NCBI Gene: 16193
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:30218112-30224973 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 15.70 cM
  • Mapping Data
    37 experiments
Strain
Comparison
more
  • SNPs within 2kb
    233 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    6
  • RFLP
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96559
 protein coding gene Chr5:30218112-30224979 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029380
 protein coding gene Chr5:27989532-27996542 (+)
A/J MGP_AJ_G0029346
 protein coding gene Chr5:27047323-27054083 (+)
AKR/J MGP_AKRJ_G0029297
 protein coding gene Chr5:28135097-28140544 (+)
BALB/cJ MGP_BALBcJ_G0029357
 protein coding gene Chr5:27573622-27581838 (+)
C3H/HeJ MGP_C3HHeJ_G0029078
 protein coding gene Chr5:28163027-28171489 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029810
 protein coding gene Chr5:29687147-29698776 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027048
 protein coding gene Chr5:24578832-24585164 (+)
CAST/EiJ MGP_CASTEiJ_G0028489
 protein coding gene Chr5:27254993-27263322 (+)
CBA/J MGP_CBAJ_G0029046
 protein coding gene Chr5:30234308-30240247 (+)
DBA/2J MGP_DBA2J_G0029195
 protein coding gene Chr5:27244474-27254087 (+)
FVB/NJ MGP_FVBNJ_G0029153
 protein coding gene Chr5:26646431-26653072 (+)
LP/J MGP_LPJ_G0029280
 protein coding gene Chr5:28417535-28423131 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029182
 protein coding gene Chr5:31192244-31198866 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029844
 protein coding gene Chr5:27707293-27713546 (+)
PWK/PhJ MGP_PWKPhJ_G0028213
 protein coding gene Chr5:26353803-26359724 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028044
 protein coding gene Chr5:27045935-27053085 (+)
WSB/EiJ MGP_WSBEiJ_G0028569
 protein coding gene Chr5:27763938-27772598 (+)



Homology
more
  • Human Ortholog
    IL6, interleukin 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL6, interleukin 6
  • Synonyms
    BSF-2, BSF2, CDF, HGF, HSF, IFNB2, IFN-beta-2, IL-6
  • Links
    NCBI Gene ID: 3569
    neXtProt AC: NX_P05231
    UniProt: P05231

  • Chr Location
    7p15.3; chr7:22725884-22732002 (+)  GRCh38
Human Diseases
more
  • Diseases
    44 with human IL6 associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    163 phenotypes from 8 alleles in 14 genetic backgrounds
    44 phenotypes from multigenic genotypes
    1 images
    855 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants show impaired immune response to pathogens, decreased T cell numbers and resistance to plasma cell neoplasia. They are defective in wound healing and liver regeneration and show increased emotionality and high bone turnover rate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    153
  • GO References
    62
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    843
  • Tissues
    71
  • cDNA Data
    21
  • Literature Summary
    97
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16193 NCBI Gene Model | MGI Sequence Detail 6862 C57BL/6J ±  kb
    transcript NM_031168 RefSeq | MGI Sequence Detail 1141 ZRU/MplStud  
    polypeptide P08505 UniProt | EBI | MGI Sequence Detail 211 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 5
      cDNA 21
      Primer pair 17
      Other 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11357, MGD-MRK-11391
    References
    more
    • Summaries
      All 1574
      Developmental Gene Expression 97
      Diseases 3
      Gene Ontology 62
      Phenotypes 855
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:355331 Mao Y, et al., Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance. J Neuroinflammation. 2024 Oct 4;21(1):249
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory