Il9r MGI Mouse Gene Detail - MGI:96564

Symbol

Il9r
Name

interleukin 9 receptor

Feature Type

protein coding gene
IDs

MGI:96564
NCBI Gene: 16199
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:32137541-32150279 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 18.82 cM, cytoband A4
Mapping Data

4 experiments

SNPs within 2kb

626 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96564	protein coding gene	Chr11:32137541-32155283 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018126	protein coding gene	Chr11:30371839-30394455 (-)
A/J	MGP_AJ_G0018099	protein coding gene	Chr11:29233796-29246907 (-)
AKR/J	MGP_AKRJ_G0018063	protein coding gene	Chr11:30158184-30170846 (-)
BALB/cJ	MGP_BALBcJ_G0018068	protein coding gene	Chr11:29428788-29442018 (-)
C3H/HeJ	MGP_C3HHeJ_G0017881	protein coding gene	Chr11:30106177-30119918 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018520	protein coding gene	Chr11:31385210-31399517 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016175	protein coding gene	Chr11:27766824-27779329 (-)
CAST/EiJ	MGP_CASTEiJ_G0017443	protein coding gene	Chr11:30135953-30149997 (-)
CBA/J	MGP_CBAJ_G0017854	protein coding gene	Chr11:32880879-32897906 (-)
DBA/2J	MGP_DBA2J_G0017964	protein coding gene	Chr11:29032841-29046516 (-)
FVB/NJ	MGP_FVBNJ_G0017958	protein coding gene	Chr11:28850341-28867114 (-)
LP/J	MGP_LPJ_G0018036	protein coding gene	Chr11:30618712-30632828 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017982	protein coding gene	Chr11:33879744-33893173 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018561	protein coding gene	Chr11:30290771-30303969 (-)
PWK/PhJ	MGP_PWKPhJ_G0017226	protein coding gene	Chr11:29183515-29196495 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017020	protein coding gene	Chr11:29980015-29997946 (-)
WSB/EiJ	MGP_WSBEiJ_G0017496	protein coding gene	Chr11:29925383-29938880 (-)

Human Ortholog

IL9R, interleukin 9 receptor

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL9R, interleukin 9 receptor
Synonyms

CD129, IL-9R
Links

HGNC:6030

NCBI Gene ID: 3581

neXtProt AC: NX_Q01113

UniProt: Q01113
Chr Location

XYq28 and Yq12

MGI Vertebrate Homology

Il9r stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IL9R
Gene Tree

Il9r

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

3
Genomic Mutations

1 involving Il9r
Incidental Mutations

CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are more susceptible to experimental autoimmune encephalomyelitis, a defect partially attributable to defective regulatory T cell function.

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All GO Annotations

22
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

4
cDNA Data

12
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

58
RefSeq

18
UniProt

7
CCDS

CCDS24517.1, CCDS48765.1

Ensembl

ENSMUSG00000020279 (Evidence)
NCBI Gene

16199

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020279	Ensembl Gene Model \| MGI Sequence Detail	12739	C57BL/6J	± kb
transcript	ENSMUST00000142396	Ensembl \| MGI Sequence Detail	1542	Not Applicable
polypeptide	ENSMUSP00000119185	Ensembl \| MGI Sequence Detail	474	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000001397 interleukin-9 receptor

(term hierarchy)
PDB

8DDD
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR003531 Short hematopoietin receptor, family 1, conserved site
GlyGen

Q01114 2 sites

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All nucleic 14

Genomic 1

cDNA 12

Primer pair 1

Microarray probesets 4

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MGD-MRK-11398

Summaries

All 59

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 30
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Il9r:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr107300	Chr11:32150466-32150472 (-)	-190 bp
Tssr107299	Chr11:32150273-32150286 (-)	-1 bp
Tssr107298	Chr11:32150248-32150271 (-)	19 bp
Tssr107297	Chr11:32149369-32149380 (-)	904 bp
Tssr107296	Chr11:32149337-32149352 (-)	934 bp
Tssr107295	Chr11:32149260-32149297 (-)	1,000 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24